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Swiss-Prot
Protein knowledgebase
TrEMBL
Computer-annotated supplement to Swiss-Prot

The UniProt Knowledgebase consists of:

UniProtKB/Swiss-Prot; a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases [More details / References / Linking to Swiss-Prot / User manual / Recent changes / Disclaimer].
UniProtKB/TrEMBL; a computer-annotated supplement of Swiss-Prot that contains all the translations of EMBL nucleotide sequence entries not yet integrated in Swiss-Prot.

These databases are developed by the Swiss-Prot groups at SIB and at EBI.

UniProt Knowledgebase Release 14.1 consists of:
UniProtKB/Swiss-Prot Release 56.1 of 02-Sep-2008: 397539 entries (More statistics)
UniProtKB/TrEMBL Release 39.1 of 02-Sep-2008: 6212793 entries (More statistics)

> Swiss-Prot headlines
First draft of the complete human proteome available in UniProtKB/Swiss-Prot (Read more...)

Access to the UniProt Knowledgebase
New UniProt web site SRS - Access to UniProtKB/Swiss-Prot, UniProtKB/TrEMBL and other databases using the Sequence Retrieval System Full text search in the UniProt Knowledgebase Advanced search in the UniProt Knowledgebase by description, gene name and organism (can be used to create html links to UniProt Knowledgebase queries) Taxonomy browser (NEWT) ViralZone - Portal to viral UniProtKB/Swiss-Prot entries BLAST similarity search by description or identification (any word in the DE, OS, OG, GN and ID lines ) by citation (RL line; UniProtKB/Swiss-Prot only) Retrieve a list of UniProtKB entries Randomly retrieve a UniProtKB entry UniProtKB Sequence/Annotation Version Database Swiss-Prot ID tracker

Documents and services
Swiss-Prot documents - user manual, release notes, indices and lots of other important documents and lists Swiss-Shop - a service that allows you to automatically obtain (by email) new UniProtKB/Swiss-Prot sequence entries relevant to your field(s) of interest Updates and submissions: Report form for updates or corrections of an existing Swiss-Prot entry or of a family of entries Sequence data submission to Swiss-Prot FTP: How to obtain a local copy of Swiss-Prot and TrEMBL UniProt Knowledgebase on DVD: Users may subscribe to the Swiss-Prot/TrEMBL CDs which are produced at each major release of the database. Please contact specifying a request for it. Human proteomics initiative (HPI) High-quality Automated and Manual Annotation of microbial Proteomes (HAMAP) Plant Proteome Annotation Project (PPAP) Toxin Annotation Project (Tox-Prot) Protein Spotlight Protéines à la «Une» Links to gene/protein specific databases and resources Links to post-translational modifications databases and resources Swissknife - a tool to parse Swiss-Prot In-Silico Analysis of Proteins Celebrating the 20th anniversary of Swiss-Prot Swiss-Prot funding crisis of 1996

Documents and services

Swiss-Prot documents - user manual, release notes, indices and lots of other important documents and lists
Swiss-Shop - a service that allows you to automatically obtain (by email) new UniProtKB/Swiss-Prot sequence entries relevant to your field(s) of interest