Orthorubulavirus (taxid:2560195)

General

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

Enzymes: RNA dependent RNA polymerase, RNA guanylyl transferase, mRNA methyltransferase

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

ENZYMES

RNA-dependent RNA polymerase [L]
Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
Neuraminidase [HN]

REPLICATION

CYTOPLASMIC

Virus attaches to host cell surface receptors through HN glycoprotein.
Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

DB LINKS

TAXONOMY Group V: Negative sense ssRNA viruses

Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Negarnaviricota
Subphylum:	Haploviricotina
Class:	Monjiviricetes
Order:	Mononegavirales
Family:	Paramyxoviridae
Genus:	Orthorubulavirus

VIRUS

Mumps rubulavirus
Achimota rubulavirus 1
Achimota rubulavirus 2
Bat mumps rubulavirus
Human rubulavirus 2
Human rubulavirus 4
Mammalian rubulavirus 5
Mapuera rubulavirus
Menangle rubulavirus
Porcine rubulavirus
Simian rubulavirus
Sosuga rubulavirus
Teviot rubulavirus
Tioman rubulavirus
Tuhoko rubulavirus 1
Tuhoko rubulavirus 2
Tuhoko rubulavirus 3

REFERENCE STRAIN Mumps virus
Sequence | Genome assembly | Proteome

Host

NATURAL HOST Humans, Apes, Pigs, Dogs

CELL TROPISM

INTERACTIONS Cell receptors:
Host-virus interaction

Ecology and disease

GEOGRAPHY Worldwide

ASSOCIATED DISEASES Mumps

TRANSMISSION Respiratory, saliva

VACCINE Mumps virus

ANTIVIRAL DRUGS

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V protein blocks also the type I and II interferon signaling pathways by interacting with and inhibiting host STAT1 and STAT2 .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

97 entries grouped by strain

reorder by protein

Mumps virus genotype B (strain Miyahara vaccine) (MuV) reference strain

8 entries

L_MUMPM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

HN_MUMPM Hemagglutinin-neuraminidase (EC 3.2.1.18)

FUS_MUMPM Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2FYZ

V_MUMPM Non-structural protein V (Non-structural protein NS1)

NCAP_MUMPM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

SH_MUMPM Small hydrophobic protein

PHOSP_MUMPM Phosphoprotein (Protein P)

MATRX_MUMPM Matrix protein

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

8 entries

HN_PIV5 Hemagglutinin-neuraminidase (EC 3.2.1.18)

1Z4V; 1Z4W; 1Z4X; 1Z4Y; 1Z4Z; 1Z50; 3TSI; 4JF7

V_PIV5 Non-structural protein V

2B5L; 2HYE; 2K48; 4I1S

L_PIV5 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

6V85; 6V86

FUS_PIV5 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1SVF; 2B9B; 4GIP; 4WSG

NCAP_PIV5 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

4XJN; 5WKN

SH_PIV5 Small hydrophobic protein

PHOSP_PIV5 Phosphoprotein (Protein P)

5WKN; 6V85; 6V86; 6VAG

MATRX_PIV5 Matrix protein (Membrane protein)

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

7 entries

HN_PI2HT Hemagglutinin-neuraminidase (EC 3.2.1.18)

L_PI2HT RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

NCAP_PI2HT Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

PHOSP_PI2HT Phosphoprotein (Protein P)

V_PI2HT Non-structural protein V

FUS_PI2HT Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

MATRX_PI2HT Matrix protein (Membrane protein)

Simian virus 41 (SV41) reference strain

6 entries

HN_SV41 Hemagglutinin-neuraminidase (EC 3.2.1.18)

FUS_SV41 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

L_SV41 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

NCAP_SV41 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

V_SV41 Non-structural protein V

MATRX_SV41 Matrix protein

Mumps virus genotype A (strain Jeryl-Lynn) (MuV)

8 entries

L_MUMPJ RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

8IZL; 8IZM; 8X01; 8YXL; 8YXM; 8YXP

PHOSP_MUMPJ Phosphoprotein (Protein P)

3BBZ; 8IZL; 8IZM; 8X01; 8YXM; 8YXO; 8YXR

SH_MUMPJ Small hydrophobic protein

NCAP_MUMPJ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

7EWQ; 7EXA

HN_MUMPJ Hemagglutinin-neuraminidase (EC 3.2.1.18)

V_MUMPJ Non-structural protein V

MATRX_MUMPJ Matrix protein

I_MUMPJ I

Mumps virus genotype N (strain L-Zagreb vaccine) (MuV)

8 entries

L_MUMPZ RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

FUS_MUMPZ Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

V_MUMPZ Non-structural protein V (Non-structural protein NS1)

NCAP_MUMPZ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

HN_MUMPZ Hemagglutinin-neuraminidase (EC 3.2.1.18)

PHOSP_MUMPZ Phosphoprotein (Protein P)

I_MUMPZ I

MATRX_MUMPZ Matrix protein

Mumps virus (strain SBL-1) (MuV)

7 entries

HN_MUMP1 Hemagglutinin-neuraminidase (EC 3.2.1.18)

FUS_MUMP1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

NCAP_MUMP1 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

V_MUMP1 Non-structural protein V (Non-structural protein NS1)

PHOSP_MUMP1 Phosphoprotein (Protein P)

MATRX_MUMP1 Matrix protein

SH_MUMP1 Small hydrophobic protein

Simian virus 41 (SV41)

1 entry

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

5 entries

HN_PI4HA Hemagglutinin-neuraminidase (EC 3.2.1.18)

NCAP_PI4HA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

V_PI4HA Non-structural protein V

PHOSP_PI4HA Phosphoprotein (Protein P)

MATRX_PI4HA Matrix protein

Mumps virus (strain SBL) (MuV)

5 entries

FUS_MUMPS Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

V_MUMPS Non-structural protein V (Non-structural protein NS1)

MATRX_MUMPS Matrix protein

PHOSP_MUMPS Phosphoprotein (Protein P)

SH_MUMPS Small hydrophobic protein

Human parainfluenza 2 virus (HPIV-2)

4 entries

V_PI2H Non-structural protein V

HN_PI2H Hemagglutinin-neuraminidase (EC 3.2.1.18)

PHOSP_PI2H Phosphoprotein (Protein P)

FUS_PI2H Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

4 entries

NCAP_PI4HB Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

PHOSP_PI4HB Phosphoprotein (Protein P)

4KYD; 4KYE

V_PI4HB Non-structural protein V

MATRX_PI4HB Matrix protein

Mumps virus (strain Enders) (MuV)

4 entries

V_MUMPE Non-structural protein V (Non-structural protein NS1)

NCAP_MUMPE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

7OZR

PHOSP_MUMPE Phosphoprotein (Protein P)

SH_MUMPE Small hydrophobic protein

Mumps orthorubulavirus (MuV)

3 entries

HN_MUMPV Hemagglutinin-neuraminidase (EC 3.2.1.18)

5B2C; 5B2D; 6JJM; 6JJN

PHOSP_MUMPV Phosphoprotein

NCAP_MUMPV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Mumps virus (strain RW) (MuV)

3 entries

FUS_MUMPR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

HN_MUMPR Hemagglutinin-neuraminidase (EC 3.2.1.18)

SH_MUMPR Small hydrophobic protein

Mumps virus (strain Kilham) (MuV)

2 entries

Human parainfluenza 2 virus (strain Greer) (HPIV-2)

1 entry

La Piedad-Michoacan-Mexico virus (LPMV)

1 entry

Mumps virus (strain Belfast) (MuV)

1 entry

Mumps virus (strain Bristol 1) (MuV)

1 entry

Mumps virus (strain Edingburgh 2) (MuV)

1 entry

Mumps virus (strain Edingburgh 4) (MuV)

1 entry

Mumps virus (strain Edingburgh 6) (MuV)

1 entry

Mumps virus (strain Matsuyama) (MuV)

1 entry

Mumps virus (strain Takahashi) (MuV)

1 entry

Mumps virus genotype B (strain Urabe vaccine AM9) (MuV)

1 entry

Parainfluenza virus 5 (isolate Canine/CPI+) (PIV5) (Simian virus 5)

1 entry

Parainfluenza virus 5 (isolate Canine/CPI-) (PIV5) (Simian virus 5)

1 entry

Parainfluenza virus 5 (isolate Human/LN) (PIV5) (Simian virus 5)

1 entry

Parainfluenza virus 5 (strain 21004-WR) (PIV5) (Simian virus 5)

1 entry

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna

(ModelArchive).

Mumps orthorubulavirus taxid:2560602

Protein	ModelArchive
Fusion glycoprotein F0	ma-jd-viral-43018
Hemagglutinin-neuraminidase	ma-jd-viral-13199
Matrix protein	ma-jd-viral-03325
Non-structural protein V	ma-jd-viral-43466
Nucleocapsid (Nucleocapsid protein)	ma-jd-viral-15253
Phosphoprotein	ma-jd-viral-37058
Small hydrophobic protein	ma-jd-viral-51092

Orthorubulavirus mapueraense taxid:3052559

Protein	ModelArchive
Attachment protein	ma-jd-viral-13216
C protein	ma-jd-viral-53220
Fusion glycoprotein F0	ma-jd-viral-43002
Matrix protein	ma-jd-viral-03321
Non-structural protein V	ma-jd-viral-43455
Nucleocapsid (Nucleocapsid protein)	ma-jd-viral-15309
Phosphoprotein	ma-jd-viral-65370
W protein	ma-jd-viral-43456