Skip to main content
ViralZone logo emblem ViralZone

Morbillivirus (taxid:11229)

VIRION

image

Enveloped, spherical. Diameter from 150nm to 300nm.

GENOME

image

Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and "polyadenylated" by the L protein during synthesis. The V protein is produced through and the C protein is produced by of The P mRNA.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through H glycoprotein.
  2. with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. , viral mRNAs are capped and in the cytoplasm.
  4. presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and , releasing the virion.
DB LINKS image image

 image image

image image

image image
TAXONOMY
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Subphylum: Haploviricotina
Class: Monjiviricetes
Order: Mononegavirales
Family:
Genus: Morbilivirus
VIRUS
Measles morbillivirus
 Canine morbillivirus
 Cetacean morbillivirus
 Feline morbillivirus
 Phocine morbillivirus
 Rinderpest morbillivirus
 Small ruminant morbillivirus
REFERENCE STRAIN Measles virus
Sequence | Genome assembly | Proteome

Host

NATURAL HOST Human, dog, cattle, cetacean
TROPISM
INTERACTIONS Cell receptors: MeV: ,
Host-virus interaction

Ecology and disease


GEOGRAPHY Worldwide
ASSOCIATED DISEASES Fever, rash
Animal: Acute febrile respiratory tract infection
TRANSMISSION Respiratory
VACCINE Canine disemper virus
Rinderpest virus
ANTIVIRAL DRUGS [MeV] (Experimental, Polymerase inhibitor)
[MeV SSPE] (Immuno stimulant)

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in

The V also blocks the type I interferon signaling pathway by interacting with and

NATURAL HOST Human, dog, cattle, cetacean
TROPISM
ASSOCIATED DISEASES Fever, rash
Animal: Acute febrile respiratory tract infection
TRANSMISSION Respiratory

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

95 entries grouped by strain

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

8 entries

Select_allDeselect_all
V_MEASC Non-structural protein V
HEMA_MEASC Hemagglutinin glycoprotein

pdb 4GJT

FUS_MEASC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

pdb 5YXW; 5YZC; 5YZD; 8UT2; 8UTF; 8UUP; 8UUQ; 9AT8

L_MEASC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MEASC Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_MEASC Matrix protein

pdb 7SKS

PHOSP_MEASC Phosphoprotein (Protein P)
C_MEASC Protein C

Rinderpest virus (strain RBOK) (RDV) reference strain

7 entries

Select_allDeselect_all
L_RINDR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HEMA_RINDR Hemagglutinin glycoprotein

pdb 3PWU

FUS_RINDR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_RINDR Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_RINDR Phosphoprotein (Protein P)
MATRX_RINDR Matrix protein
C_RINDR Protein C

Peste-des-petits-ruminants virus (PPRV) reference strain

2 entries

Select_allDeselect_all
NCAP_PPRV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PPRV Phosphoprotein

pdb 5LXJ

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

8 entries

Select_allDeselect_all
NCAP_MEASE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
HEMA_MEASE Hemagglutinin glycoprotein

pdb 2RKC; 2ZB5; 2ZB6; 3ALW; 3ALX; 3ALZ; 3INB

L_MEASE RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
V_MEASE Non-structural protein V
FUS_MEASE Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

pdb 8XNE; 8XO2; 8XO3; 8XO4; 8XO5; 8XO6; 8XO7; 8XO8

PHOSP_MEASE Phosphoprotein (Protein P)

pdb 1OKS; 2K9D

C_MEASE Protein C
MATRX_MEASE Matrix protein

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

8 entries

Select_allDeselect_all
HEMA_MEASA Hemagglutinin glycoprotein
FUS_MEASA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
L_MEASA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MEASA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASA Phosphoprotein (Protein P)

pdb 4BHV; 4C5Q

V_MEASA Non-structural protein V
MATRX_MEASA Matrix protein
C_MEASA Protein C

Rinderpest virus (strain RBOK) (RDV)

1 entry

V_RINDR Non-structural protein V

Canine distemper virus (strain Onderstepoort) (CDV)

7 entries

Select_allDeselect_all
HEMA_CDVO Hemagglutinin glycoprotein

pdb 7CJQ

NCAP_CDVO Nucleoprotein (Protein N) (Nucleocapsid protein)
FUS_CDVO Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
L_CDVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_CDVO Phosphoprotein (Protein P)
MATRX_CDVO Matrix protein
C_CDVO Protein C

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

7 entries

Select_allDeselect_all
FUS_MEASI Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_MEASI Hemagglutinin glycoprotein
NCAP_MEASI Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_MEASI Non-structural protein V
PHOSP_MEASI Phosphoprotein (Protein P)
MATRX_MEASI Matrix protein
C_MEASI Protein C

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

7 entries

Select_allDeselect_all
FUS_MEASY Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_MEASY Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
HEMA_MEASY Hemagglutinin glycoprotein
V_MEASY Non-structural protein V
PHOSP_MEASY Phosphoprotein (Protein P)
MATRX_MEASY Matrix protein
C_MEASY Protein C

Phocine distemper virus (PDV)

7 entries

Select_allDeselect_all
FUS_PHODV Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_PHODV Hemagglutinin glycoprotein
PHOSP_PHODV Phosphoprotein (Protein P)
NCAP_PHODV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_PHODV Non-structural protein V
MATRX_PHODV Matrix protein
C_PHODV Protein C

Rinderpest virus (strain Kabete O) (RDV)

6 entries

Select_allDeselect_all
HEMA_RINDK Hemagglutinin glycoprotein
FUS_RINDK Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_RINDK Phosphoprotein (Protein P)
V_RINDK Non-structural protein V
MATRX_RINDK Matrix protein
C_RINDK Protein C

Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)

5 entries

Select_allDeselect_all
HEMA_MEASH Hemagglutinin glycoprotein
NCAP_MEASH Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

pdb 4UFT

FUS_MEASH Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_MEASH Matrix protein
Y7K_MEASH Putative uncharacterized 7 kDa protein

Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)

3 entries

Select_allDeselect_all
NCAP_MEASF Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

pdb 5E4V

FUS_MEASF Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_MEASF Phosphoprotein (Protein P)

pdb 3ZDO; 6HTL

Rinderpest virus (strain L) (RDV)

3 entries

Select_allDeselect_all
HEMA_RINDL Hemagglutinin glycoprotein
FUS_RINDL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_RINDL Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)

2 entries

Select_allDeselect_all
NCAP_MEASM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

pdb 1T6O; 6H5S

PHOSP_MEASM Phosphoprotein

pdb 1T6O; 5E4V

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)

2 entries

Select_allDeselect_all
V_MEASW Non-structural protein V
NCAP_MEASW Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Measles virus (strain Edmonston-Zagreb vaccine) (MeV) (Subacute sclerose panencephalitis virus)

2 entries

Select_allDeselect_all
NCAP_MEASZ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_MEASZ Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

Canine distemper virus (strain A92-27/4) (CDV)

1 entry

HEMA_CDVA4 Hemagglutinin glycoprotein

Canine distemper virus (strain A92-6) (CDV)

1 entry

HEMA_CDVA6 Hemagglutinin glycoprotein

Canine distemper virus (strain Convac vaccine) (CDV)

1 entry

HEMA_CDVC Hemagglutinin glycoprotein

Measles virus (strain Biken) (MeV) (Subacute sclerosing panencephalitis virus (strain Biken))

1 entry

MATRX_MEASB Matrix protein

Measles virus (strain Hu2) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

MATRX_MEASU Matrix protein

Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

FUS_MEASL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

Measles virus (strain Philadelphia-26) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

FUS_MEASP Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

Measles virus (strain Shanghai-191 vaccine) (MeV)

1 entry

NCAP_MEASS Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Rinderpest virus (strain Kuwait 82/1) (RDV)

1 entry

NCAP_RINDU Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Rinderpest virus (strain RBT1) (RDV)

1 entry

FUS_RINDB Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Measles morbillivirus taxid:11234

Measles virus (strain Edmonston B) taxid:70146

Measles virus (strain Edmonston) taxid:11235

Measles virus (strain Ichinose-B95a) taxid:645098

Peste-des-petits-ruminants virus taxid:2593991

Phocine distemper virus taxid:11240

Rinderpest virus (strain Kabete O) taxid:11242