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Mammarenavirus (taxid:1653394)

VIRION

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Enveloped, spherical. Diameter from 60 to 300 nm.

GENOME

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Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.

GENE EXPRESSION

Both segments are . The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messenger RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.

ENZYMES

REPLICATION

CYTOPLASM

  1. Virus to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell by .
  2. of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
  3. , viral mRNAs are capped in the cytoplasm.
  4. presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the Z protein under the plasma membrane and , releasing the virion.
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TAXONOMY
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Subphylum: Polyploviricotina
Class: Bunyaviricetes
Order:Hareavirales
Family:
Genus: Mammarenavirus
VIRUS
Lymphocytic choriomeningitis mammarenavirus
 Allpahuayo mammarenavirus
 Argentinian mammarenavirus
 Bear Canyon mammarenavirus
 Brazilian mammarenavirus
 Cali mammarenavirus
 Chapare mammarenavirus
 Cupixi mammarenavirus
 Flexal mammarenavirus
 Gairo mammarenavirus
 Guanarito mammarenavirus
 Ippy mammarenavirus
 Lassa mammarenavirus
 Latino mammarenavirus
 Loei River mammarenavirus
 Lujo mammarenavirus
 Luna mammarenavirus
 Lunk mammarenavirus
 Machupo mammarenavirus
 Mariental mammarenavirus
 Merino Walk mammarenavirus
 Mobala mammarenavirus
 Mopeia mammarenavirus
 Okahandja mammarenavirus
 Oliveros mammarenavirus
 Paraguayan mammarenavirus
 Pirital mammarenavirus
 Ryukyu mammarenavirus
 Serra do Navio mammarenavirus
Solwezi mammarenavirus
 Souris mammarenavirus
 Tacaribe mammarenavirus
 Tamiami mammarenavirus
 Wenzhou mammarenavirus
 Whitewater Arroyo mammarenavirus
REFERENCE STRAIN Lymphocytic choriomeningitis virus
Sequence: L S | Genome assembly | Proteome
Lassa virus
Sequence: L S | Genome assembly | Proteome
Tacaribe virus
Sequence: L S | Genome assembly | Proteome

Host

NATURAL HOST Reservoir: Rodents
Occasional: Human
CELL TROPISM Macrophages
INTERACTIONS Cell receptors: LCMV and LFV:
JUNV and MACV:
Host-virus interaction

Ecology and disease


GEOGRAPHY worldwide (LCMV)
Africa (LASV, LUJV)
America(JUNV, MACV, SABV, GTOV, CHPV)
Europe
ASSOCIATED DISEASES Human: Encephalitis (LCMV), (LASV, LUJV, JUNV, MACV, SABV, GTOV, CHPV)
TRANSMISSION ,
VACCINE Candid#1 against Junin virus
ANTIVIRAL DRUGS

Host-virus interaction

Inhibition of host Interferon induction

The Z protein plays a role in

NATURAL HOST Reservoir: Rodents
TROPISM
ASSOCIATED DISEASES Human: Encephalitis (LCMV), (LASV)
TRANSMISSION ,
i9ctv

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

88 entries grouped by strain

Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV) reference strain

4 entries

Select_allDeselect_all
GLYC_CPXVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_CPXVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_CPXVB RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_CPXVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain

4 entries

Select_allDeselect_all
Z_LASSJ RING finger protein Z (Protein Z) (Zinc-binding protein)

pdb 2M1S; 5I72

GLYC_LASSJ Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

pdb 4ZJF; 5FT2; 5OMI; 5VK2; 6JGY; 6P91; 6P95; 7PUY; 7PVD; 7SGD; 7SGF

NCAP_LASSJ Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

pdb 3MWP; 3MWT; 3MX2; 3MX5; 3Q7B; 3Q7C; 4FVU; 4G9Z; 4GV3; 4GV6; 4GV9; 7V37; 7V38; 7V39; 7V3A; 7V3B; 7V3C

L_LASSJ RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain

4 entries

Select_allDeselect_all
GLYC_LATVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_LATVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_LATVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_LATVB RING finger protein Z (Protein Z) (Zinc-binding protein)

Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain

4 entries

Select_allDeselect_all
GLYC_LYCVA Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

pdb 5JWD; 5JWE; 7P0A; 7P0T

NCAP_LYCVA Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

pdb 4O6H; 4O6I; 8CNL

L_LYCVA RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

pdb 3JSB; 5LTF; 5LTN; 5LTS; 5T2T; 7X6S; 7X6V

Z_LYCVA RING finger protein Z (Protein Z) (Zinc-binding protein)

pdb 7X6V

Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV) reference strain

4 entries

Select_allDeselect_all
GLYC_OLVVA Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_OLVVA RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_OLVVA RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_OLVVA Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus) reference strain

4 entries

Select_allDeselect_all
GLYC_PARVP Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_PARVP RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_PARVP RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_PARVP Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain

4 entries

Select_allDeselect_all
GLYC_PIRVV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_PIRVV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_PIRVV RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_PIRVV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain

4 entries

Select_allDeselect_all
GLYC_TACVF Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
NCAP_TACVF Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

pdb 4GVE

L_TACVF RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_TACVF RING finger protein Z (Protein Z) (Zinc-binding protein)

Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV) reference strain

4 entries

Select_allDeselect_all
GLYC_WWAVU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

pdb 5NSJ; 6HJ4; 6HJ5; 8PXJ

L_WWAVU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_WWAVU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_WWAVU RING finger protein Z (Protein Z) (Zinc-binding protein)

Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)

4 entries

Select_allDeselect_all
GLYC_ALLVP Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_ALLVP RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_ALLVP RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_ALLVP Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)

4 entries

Select_allDeselect_all
GLYC_BCNVU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_BCNVU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_BCNVU RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_BCNVU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)

4 entries

Select_allDeselect_all
GLYC_CHAVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_CHAVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_CHAVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_CHAVB RING finger protein Z (Protein Z) (Zinc-binding protein)

Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)

4 entries

Select_allDeselect_all
GLYC_GTOVV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

pdb 4C53

L_GTOVV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_GTOVV RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_GTOVV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)

4 entries

Select_allDeselect_all
GLYC_IPPYV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_IPPYV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_IPPYV RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_IPPYV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Junin mammarenavirus (JUNV) (Junn mammarenavirus)

4 entries

Select_allDeselect_all
GLYC_JUNIN Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

pdb 2L0Z; 5EN2; 5W1K

NCAP_JUNIN Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_JUNIN RING finger protein Z (Protein Z) (Zinc-binding protein)

pdb 7EJU

L_JUNIN RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

Machupo virus (MACV)

4 entries

Select_allDeselect_all
GLYC_MACHU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_MACHU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

pdb 7VGQ; 7VH1; 7VH2; 7VH3

NCAP_MACHU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_MACHU RING finger protein Z (Protein Z) (Zinc-binding protein)

pdb 7VGQ; 7VH1

Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)

4 entries

Select_allDeselect_all
GLYC_MOBVC Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_MOBVC RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_MOBVC RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_MOBVC Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)

4 entries

Select_allDeselect_all
GLYC_SABVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_SABVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_SABVB RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_SABVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)

4 entries

Select_allDeselect_all
GLYC_TAMVU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_TAMVU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
Z_TAMVU RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_TAMVU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Lassa virus (strain GA391) (LASV)

2 entries

Select_allDeselect_all
GLYC_LASSG Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
NCAP_LASSG Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Lymphocytic choriomeningitis virus (strain WE) (LCMV)

2 entries

Select_allDeselect_all
GLYC_LYCVW Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

pdb 1S7Q; 1S7R; 1S7S; 1S7T; 1S7U; 1S7V; 1S7W; 1S7X; 3MKO; 3QUK; 3QUL; 3ROL; 3ROO; 3TBS; 3TBT; 3TBV; 3TBW; 3TBY; 4NSK; 5INE

NCAP_LYCVW Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

Mopeia virus (MOPV)

2 entries

Select_allDeselect_all
GLYC_MOPEI Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
NCAP_MOPEI Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

pdb 6T2A; 6T6L

Pichinde mammarenavirus (PICV) (Pichind mammarenavirus)

2 entries

Select_allDeselect_all
GLYC_PIARV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
NCAP_PIARV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

pdb 3P4N

Mammarenavirus lassaense

1 entry

L_LASV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

pdb 5IZH; 5J1N; 5J1P

Tacaribe virus (strain TRVL 11598) (TCRV)

1 entry

GLYC_TACVT Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

Tacaribe virus (strain V5) (TCRV)

1 entry

GLYC_TACV5 Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

Tacaribe virus (strain V7) (TCRV)

1 entry

GLYC_TACV7 Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) taxid:144752

Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) taxid:3052298

Chapare mammarenavirus (isolate Human/Bolivia/810419/2003) taxid:3052302

Lunk virus NKS-1 taxid:1134579

Lymphocytic choriomeningitis virus (strain Armstrong) taxid:11624

Machupo virus taxid:3052317

Mammarenavirus choriomeningitidis taxid:3052303

Mammarenavirus gairoense taxid:3052306

Mammarenavirus lujoense taxid:3052314

Mammarenavirus lunaense taxid:3052315

Mammarenavirus marientalense taxid:3052318

Mammarenavirus merinoense taxid:3052319

Mammarenavirus okahandjaense taxid:3052321

Mammarenavirus wenzhouense taxid:3052330

Morogoro mammarenavirus taxid:573900

Pichinde mammarenavirus taxid:3052300

Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) taxid:3052324

Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) taxid:3052329

Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) taxid:3052331