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Inhibition of host MDA5 by virus (kw:KW-1089)

Upon viral infection, the cytosolic receptor recognizes long viral dsRNAs and initiates an antiviral signaling cascade by interacting with the downstream partner , located to the mitochondria. This signaling pathway leads to the establishment of an antiviral state characterized by expression of antiviral cytokines and interferons. The protein belongs to the RNA helicase family. ISGylation of MDA5 would be crutial for its function .

Several viruses encode proteins that directly interfere with to decrease interferon production by infected cells. For example, all viruses from paramyxovirinae subfamily encode a able to interact with and block interaction with , its downstream partner in the cascade. The interaction has been investigated in detail and the C-terminal domain of the V proteins is responsible for the binding of the helicase domain of .







Inhibition of MDA5




Links Uniprot Keyword: KW-1089
GO ontology: GO:0039554
Virus -Paramyxovirus V proteins
(, Paramyxovirinae)

-SARS-CoV-2 PLpro nsp3 (, )

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

56 entries grouped by strain

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

1 entry

NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

1 entry

V_HENDH Non-structural protein V

Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain

1 entry

POLN_HEVCH Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

1 entry

RNB_HHV11 Accessory factor US11 (Vmw21)

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

1 entry

RNB_HHV2H Probable RNA-binding protein

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

1 entry

V_PI2HT Non-structural protein V

Human respiratory syncytial virus B (strain B1) reference strain

1 entry

NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

1 entry

V_MEASC Non-structural protein V

Mumps virus genotype B (strain Miyahara vaccine) (MuV) reference strain

1 entry

V_MUMPM Non-structural protein V (Non-structural protein NS1)

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

1 entry

V_NDVB1 Protein V

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

1 entry

V_PIV5 Non-structural protein V

pdb 2B5L; 2HYE; 2K48; 4I1S

Poliovirus type 1 (strain Mahoney) reference strain

1 entry

POLG_POL1M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1AL2; 1AR6; 1AR7; 1AR8; 1AR9; 1ASJ; 1DGI; 1FPT; 1HXS; 1L1N; 1NG7; 1NN8; 1PO1; 1PO2; 1POV; 1RA6; 1RA7; 1RAJ; 1RDR; 1TQL; 1VBD; 1XYR; 2BBL; 2BBP; 2IJD; 2IJF; 2ILY; 2ILZ; 2IM0; 2IM1; 2IM2; 2IM3; 2PLV; 3EPC; 3IYB; 3IYC; 3J3O; 3J3P; 3J48; 3J8F; 3J9F; 3JBC; 3JBD; 3JBE; 3JBF; 3JBG; 3OL7; 4DCD; 4K4S; 4K4T; 4K4U; 4K4V; 4K4W; 4NLO; 4NLP; 4NLQ; 4NLR; 4NLS; 4NLT; 4NLU; 4NLV; 4NLW; 4NLX; 4NLY; 4R0E; 5KTZ; 5KU0; 5KU2; 5KWL; 5Z3Q; 6HLV; 6P9O; 6P9W; 6PSZ; 9FQ2

Simian virus 41 (SV41) reference strain

1 entry

V_SV41 Non-structural protein V

Tupaia paramyxovirus (TPMV) reference strain

1 entry

V_TPMV Non-structural protein V

Bovine respiratory syncytial virus (strain 391-2) (BRS)

1 entry

NCAP_BRSV3 Nucleoprotein (Protein N) (Nucleocapsid protein)

Bovine respiratory syncytial virus (strain Rb94) (BRS)

1 entry

NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)

Coxsackievirus A16 (strain G-10)

1 entry

POLG_CX16G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 7H2T; 7H2U; 7H2V; 7H2W; 7H2X; 7H2Y; 7H2Z; 7H30; 7H31; 7H32; 7H33; 7H34; 7H35; 7H36; 7H37; 7H38; 7H39; 7H3A; 7H3B; 7H3C; 7H3D; 7H3E; 7H3F; 7H3G; 7H3H; 7H3I; 7H3J; 7H3K; 7H3L; 7H3M; 7H3N; 7H3O; 7H3P; 7H3Q; 7H3R; 7H3S; 7H3T; 7H3U; 7H3V; 7H3W; 7H3X; 7H3Y; 7H3Z; 7H40; 7H41; 7H42; 7H43; 7H44; 7H45; 7H46; 7H47; 7H48; 7H49; 7H4A; 7H4B; 7H4C; 7H4D; 7H4E; 7H4F; 7H4G; 7H4H; 7H4I; 7H4J; 7H4K; 7H4L; 7H4M; 7H4N; 7H4O; 7H4P; 7H4Q; 7H4R; 7H4S; 7H4T; 7H4U; 7H4V; 7H4W; 7H4X; 7H4Y; 7H4Z; 7H50; 7H51; 7H52; 7H53; 7H54; 7H55; 7HOC; 7HOD; 7HOE; 7HOF; 7HOG; 7HOH; 7HOI; 7HUF; 7HUG; 7HUH; 7HUI; 7HUJ; 7HUK; 7HUL; 7HUN; 7HUO; 7HUP; 7HUQ; 7HUR; 7HUS; 7HUT; 7HUU; 7HUV; 7HUW; 7HUX; 7HUY; 7HUZ; 7HV0; 7HV1; 7HV2; 7HV3; 7HV4; 7HV5; 7HV6; 7HV7; 7HV8; 7HV9; 7HVA; 7HVB; 7HVC; 7HVD; 7HVE; 7HVF; 7HVG; 7HVH; 7HVI; 7HVJ; 7HVK; 7HVL; 7HVM; 7HVN; 7HVO; 7HVQ; 7HVR; 7HVS; 7HVT; 7HVU; 7HVV; 7HVW; 7HVX; 7HVY; 7HVZ; 7HW0; 7HW1; 7HW3; 7HW4; 7HW5; 7HW6; 7HW8; 7HW9; 7HWA; 7HWB; 7HWC; 7HWD; 7HWE; 7HWF; 7HWG; 7HWH; 7HWI; 7HWJ; 7HWK; 7HWL; 7HWM; 7HWN; 7HWO; 7HWP; 7HWQ; 7HWR; 7HWS; 7HWT; 7HWU; 7HWV; 7HWW; 7HWX; 7HWY; 7HWZ; 7HX0; 7HX1; 7HX2; 7HX3; 7HX4; 7HX5; 7HX6; 7HX7; 7HX8; 7HX9; 7HXA; 7HXB; 7HXC; 7HXD; 7HXE; 7HXF; 7HXG; 7HXH; 7HXI; 7HXJ; 7HXK; 7HXL; 7HXM; 7HXN; 7HXO; 7HXP; 7HXQ; 7HXR; 7HXS; 7HXT; 7HXU; 7HXV; 7HXW; 7HXX; 7HXY; 7HXZ; 7HY0; 7HY1; 7HY2; 7HY3; 7HY4; 7HY5; 7HY6; 7HY7; 7HY8; 7HY9; 7HYA; 7HYB; 7HYC; 7HYD; 7HYE; 7HYF; 7HYG; 7HYH; 7HYI; 7HYJ; 7HYK; 7HYL; 7HYM; 7HYN; 7HYO; 7HYP; 7HYQ; 7HYR; 7HYS; 7HYT; 7HYU; 7HYV; 7HYW; 7HYX; 7HYY; 7HYZ; 7HZ0; 7HZ1; 7HZ2; 7HZ3; 7HZ4; 7HZ5; 7HZ6; 7HZ7; 7HZ8; 7HZ9; 7HZA; 7HZB; 7HZC; 7HZD; 7HZE; 7HZF; 7HZG; 7HZH; 7HZI; 7HZJ; 7HZK; 7HZL; 7HZM; 7HZN; 7HZO; 7HZP; 7HZQ; 7HZR; 7HZS; 7HZT; 7HZU; 8POA

Coxsackievirus A16 (strain Tainan/5079/98)

1 entry

POLG_CX16T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 4MG3; 5C8C; 6LHT; 7Y7M; 7YMS

Coxsackievirus B3 (strain Nancy)

1 entry

POLG_CXB3N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 2VB0; 2ZTX; 2ZTY; 2ZTZ; 2ZU1; 2ZU3; 3CDU; 3CDW; 4WFX; 4WFY; 4WFZ; 4Y2A; 6S3A; 6T3W; 7LMS; 7QUW; 7W0Q; 7W0S; 7W0T; 8S6F; 8Y2T

Coxsackievirus B3 (strain Woodruff)

1 entry

POLG_CXB3W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1COV; 1JEW; 3JD7

Human enterovirus 71 (EV71) (EV-71)

1 entry

POLG_HE71 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 5GQ1; 5GRB; 8A5L

Human enterovirus 71 (strain 7423/MS/87) (EV71) (EV-71)

1 entry

POLG_HE71M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 3W95; 6HLW; 6I2K

Human enterovirus 71 (strain USA/BrCr/1970) (EV71) (EV-71)

1 entry

POLG_HE71B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

Human enterovirus D68 (EV68) (EV-68)

1 entry

POLG_HED68 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 4WM7; 4WM8; 5BNN; 5BNO; 5BNP; 6HLN; 6HMV; 7GNV; 7GNW; 7GNX; 7GNY; 7GNZ; 7GO0; 7GO1; 7GO2; 7GO3; 7GO4; 7GO5; 7GO6; 7GO7; 7GO8; 7GO9; 7GOA; 7GOB; 7GOC; 7GOD; 7GOE; 7GOF; 7GOG; 7GOH; 7GOI; 7GOJ; 7GOK; 7GOL; 7GOM; 7GON; 7GOO; 7GOP; 7GOQ; 7GOR; 7GOS; 7GOT; 7GOU; 7GOV; 7GOW; 7GOX; 7GOY; 7GOZ; 7GP0; 7GP1; 7GP2; 7GP3; 7GP4; 7GP5; 7GP6; 7GP7; 7GP8; 7GP9; 7GPA; 7GPC; 7GPD; 7GPE; 7GPF; 7GPG; 7GPH; 7GPI; 7GPJ; 7GPK; 7GPL; 7GPM; 7GPN; 7GPO; 7GPP; 7GPQ; 7GPR; 7GPS; 7GPT; 7GPU; 7GPV; 7GPW; 7GPX; 7GPY; 7GPZ; 7GQ0; 7GQ1; 7GQ2; 7GQ3; 7GQ4; 7GQ5; 7GQ6; 7GQ7; 7GQ8; 7GQ9; 7GQA; 7GQB; 7GQC; 7GQD; 7GQE; 7GQF; 7GQG; 7GQH; 7GQI; 7GQJ; 7GQK; 7GQL; 7GQM; 7GQN; 7GQO; 7GQP; 7GQQ; 7GQR; 7JRE; 8CNX

Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

1 entry

RNB_HHV1M RNA-binding protein (Vmw21)

Human parainfluenza 2 virus (HPIV-2)

1 entry

V_PI2H Non-structural protein V

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

1 entry

V_PI4HA Non-structural protein V

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

1 entry

V_PI4HB Non-structural protein V

Human respiratory syncytial virus

1 entry

NCAP_HRSV Nucleoprotein (Protein N) (Nucleocapsid protein)

pdb 4V5V

Human respiratory syncytial virus A (strain A2)

1 entry

NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

pdb 2WJ8; 2YHM; 4BKK; 4UC6; 4UC7; 4UC8; 4UC9; 4UCA; 4UCB; 4UCC; 4UCD; 4UCE; 6YJL; 8OOU; 8OP1; 8OP2

Human respiratory syncytial virus B (strain 18537)

1 entry

NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

V_MEASE Non-structural protein V

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

V_MEASA Non-structural protein V

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

V_MEASW Non-structural protein V

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

V_MEASI Non-structural protein V

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

1 entry

V_MEASY Non-structural protein V

Mumps virus (strain Enders) (MuV)

1 entry

V_MUMPE Non-structural protein V (Non-structural protein NS1)

Mumps virus (strain SBL) (MuV)

1 entry

V_MUMPS Non-structural protein V (Non-structural protein NS1)

Mumps virus (strain SBL-1) (MuV)

1 entry

V_MUMP1 Non-structural protein V (Non-structural protein NS1)

Mumps virus genotype A (strain Jeryl-Lynn) (MuV)

1 entry

V_MUMPJ Non-structural protein V

Mumps virus genotype N (strain L-Zagreb vaccine) (MuV)

1 entry

V_MUMPZ Non-structural protein V (Non-structural protein NS1)

Newcastle disease virus (strain Ulster/2C) (NDV)

1 entry

V_NDVU2 Non-structural protein V

Nipah virus

1 entry

V_NIPAV Non-structural protein V

Phocine distemper virus (PDV)

1 entry

V_PHODV Non-structural protein V

Poliovirus type 1 (strain Sabin)

1 entry

POLG_POL1S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 8E8Z

Poliovirus type 2 (strain Lansing)

1 entry

POLG_POL2L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1EAH; 3EPF

Poliovirus type 2 (strain W-2)

1 entry

POLG_POL2W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

Poliovirus type 3 (strain 23127)

1 entry

POLG_POL32 Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein ...

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

1 entry

POLG_POL3L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

pdb 1PIV; 1PVC; 1VBA; 1VBB; 1VBC; 1VBE; 3EPD; 3IYB; 3IYC; 5O5B; 5O5P; 8E8R; 8E8X

Rinderpest virus (strain Kabete O) (RDV)

1 entry

V_RINDK Non-structural protein V

Rinderpest virus (strain RBOK) (RDV)

1 entry

V_RINDR Non-structural protein V

Sendai virus (strain Fushimi) (SeV)

1 entry

V_SENDF Protein V

Sendai virus (strain Hamamatsu) (SeV)

1 entry

V_SENDA Protein V

Sendai virus (strain Harris) (SeV)

1 entry

V_SENDH Protein V

Sendai virus (strain Ohita) (SeV)

1 entry

V_SENDO Protein V

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

1 entry

V_SENDZ Protein V