Paramyxoviridae (taxid:11158)
VIRION

Enveloped, spherical. Diameter of about 150 nm.
GENOME
Negative-stranded RNA linear genome, about 15 kb in size.
Encodes for eight proteins.
Enzymes: RNA dependent RNA polymerase, RNA guanylyl transferase, mRNA methyltransferase, (Neuraminidase)
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. Most express a C protein by leaky scanning and V/W proteins by mRNA editing.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
- Neuraminidase [HN]
REPLICATION
CYTOPLASMIC
- Virus attaches to host cell surface receptors through HN, H or G glycoproteins.
- Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
- sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthesized antigenomes and genomes.
- The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.
Host-virus interaction
Inhibition of host Interferon induction
The V protein plays a role in inhibition of MDA-5 antiviral signaling
The Nipah P,V and W proteins play a role in inhibition of STAT1 antiviral signaling
The Sendai C protein plays a role in inhibition of STAT1 antiviral signaling
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)340 entries grouped by strain
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
9 entries
Sendai virus (strain Ohita) (SeV) reference strain
7 entries
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
8 entries
Mumps virus genotype B (strain Miyahara vaccine) (MuV) reference strain
8 entries
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
8 entries
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
8 entries
Rinderpest virus (strain RBOK) (RDV) reference strain
7 entries
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
7 entries
Simian virus 41 (SV41) reference strain
6 entries
Tupaia paramyxovirus (TPMV) reference strain
4 entries
Sendai virus (strain Enders) (SeV) reference strain
1 entry
Peste-des-petits-ruminants virus (PPRV) reference strain
2 entries
Nipah virus
9 entries
Sendai virus (strain Fushimi) (SeV)
9 entries
Sendai virus (strain Hamamatsu) (SeV)
9 entries
Sendai virus (strain Ohita) (SeV)
2 entries
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))
9 entries
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
8 entries
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
8 entries
Mumps virus genotype A (strain Jeryl-Lynn) (MuV)
8 entries
Mumps virus genotype N (strain L-Zagreb vaccine) (MuV)
8 entries
Rinderpest virus (strain RBOK) (RDV)
1 entry
Canine distemper virus (strain Onderstepoort) (CDV)
7 entries
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))
7 entries
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
7 entries
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
7 entries
Mumps virus (strain SBL-1) (MuV)
7 entries
Phocine distemper virus (PDV)
7 entries
Sendai virus (strain Harris) (SeV)
7 entries
Simian virus 41 (SV41)
1 entry
Bovine parainfluenza 3 virus (BPIV-3)
6 entries
Rinderpest virus (strain Kabete O) (RDV)
6 entries
Human parainfluenza 1 virus (strain C39) (HPIV-1)
5 entries
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
5 entries
Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)
5 entries
Mumps virus (strain SBL) (MuV)
5 entries
Newcastle disease virus (strain Beaudette C/45) (NDV)
5 entries
Human parainfluenza 2 virus (HPIV-2)
4 entries
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)
4 entries
Mumps virus (strain Enders) (MuV)
4 entries
Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)
4 entries
Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)
3 entries
Mumps orthorubulavirus (MuV)
3 entries
Mumps virus (strain RW) (MuV)
3 entries
Rinderpest virus (strain L) (RDV)
3 entries
Sendai virus (strain Enders) (SeV)
2 entries
Human parainfluenza 1 virus (strain C35) (HPIV-1)
2 entries
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)
2 entries
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)
2 entries
Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
2 entries
Human parainfluenza 1 virus (strains A1426 / 86-315 / 62m-753) (HPIV-1)
2 entries
Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)
2 entries
Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)
2 entries
Measles virus (strain Edmonston-Zagreb vaccine) (MeV) (Subacute sclerose panencephalitis virus)
2 entries
Mumps virus (strain Kilham) (MuV)
2 entries
Newcastle disease virus (strain B1-Hitchner/47) (NDV)
2 entries
Newcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)
2 entries
Newcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))
2 entries
Newcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)
2 entries
Newcastle disease virus (strain D26/76) (NDV)
2 entries
Newcastle disease virus (strain Her/33) (NDV)
2 entries
Newcastle disease virus (strain Italien/45) (NDV)
2 entries
Newcastle disease virus (strain Miyadera/51) (NDV)
2 entries
Newcastle disease virus (strain Queensland/66) (NDV)
2 entries
Newcastle disease virus (strain Ulster/2C) (NDV)
2 entries
Sendai virus (strain 6/94) (SeV)
2 entries
Avian paramyxovirus 1 (NDV) (Avian orthoavulavirus 1)
1 entry
Canine distemper virus (strain A92-27/4) (CDV)
1 entry
Canine distemper virus (strain A92-6) (CDV)
1 entry
Canine distemper virus (strain Convac vaccine) (CDV)
1 entry
Human parainfluenza 2 virus (strain Greer) (HPIV-2)
1 entry
Human parainfluenza 3 virus (strain Aus/124854/74) (HPIV-3)
1 entry
Human parainfluenza 3 virus (strain Tex/12677/83) (HPIV-3)
1 entry
Human parainfluenza 3 virus (strain Tex/545/80) (HPIV-3)
1 entry
Human parainfluenza 3 virus (strain Tex/9305/82) (HPIV-3)
1 entry
Human parainfluenza 3 virus (strain Wash/1511/73) (HPIV-3)
1 entry
Human parainfluenza 3 virus (strain Wash/641/79) (HPIV-3)
1 entry
La Piedad-Michoacan-Mexico virus (LPMV)
1 entry
Measles virus (strain Biken) (MeV) (Subacute sclerosing panencephalitis virus (strain Biken))
1 entry
Measles virus (strain Hu2) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Measles virus (strain Philadelphia-26) (MeV) (Subacute sclerose panencephalitis virus)
1 entry
Measles virus (strain Shanghai-191 vaccine) (MeV)
1 entry
Mumps virus (strain Belfast) (MuV)
1 entry
Mumps virus (strain Bristol 1) (MuV)
1 entry
Mumps virus (strain Edingburgh 2) (MuV)
1 entry
Mumps virus (strain Edingburgh 4) (MuV)
1 entry
Mumps virus (strain Edingburgh 6) (MuV)
1 entry
Mumps virus (strain Matsuyama) (MuV)
1 entry
Mumps virus (strain Takahashi) (MuV)
1 entry
Mumps virus genotype B (strain Urabe vaccine AM9) (MuV)
1 entry
Newcastle disease virus (isolate AF2240) (NDV)
1 entry
Newcastle disease virus (strain Chi/85) (NDV)
1 entry
Newcastle disease virus (strain Iba/85) (NDV)
1 entry
Newcastle disease virus (strain Kansas) (NDV)
1 entry
Newcastle disease virus (strain Texas) (NDV)
1 entry
Parainfluenza virus 5 (isolate Canine/CPI+) (PIV5) (Simian virus 5)
1 entry
Parainfluenza virus 5 (isolate Canine/CPI-) (PIV5) (Simian virus 5)
1 entry
Parainfluenza virus 5 (isolate Human/LN) (PIV5) (Simian virus 5)
1 entry
Parainfluenza virus 5 (strain 21004-WR) (PIV5) (Simian virus 5)
1 entry
Rinderpest virus (strain Kuwait 82/1) (RDV)
1 entry
Rinderpest virus (strain RBT1) (RDV)
1 entry
Sendai virus (strain Nagoya) (SeV)
1 entry
Achimota virus 1 taxid:1261100
Achimota virus 2 taxid:1261101
Caprine parainfluenza virus 3 taxid:1529392
Cedar virus taxid:1221391
Ghana virus taxid:2847089
Hendra virus (isolate Horse/Autralia/Hendra/1994) taxid:928303
Henipavirus hendraense taxid:3052223
Human parainfluenza virus 1 strain Washington/1964 taxid:188538
Human respirovirus 1 taxid:12730
Protein | ModelArchive |
Fusion glycoprotein F0 | ma-jd-viral-43015 |
Hemagglutinin | ma-jd-viral-13174 |
J virus taxid:322067
Measles morbillivirus taxid:11234
Measles virus (strain Edmonston B) taxid:70146
Protein | ModelArchive |
Fusion glycoprotein F0 | ma-jd-viral-43011 |
Measles virus (strain Edmonston) taxid:11235
Protein | ModelArchive |
Fusion glycoprotein F0 | ma-jd-viral-43011 |