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Tombusviridae (taxid:39738)

VIRION

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Non-enveloped, spherical, icosahedral, about 28-34 nm in diameter, capsid with a . 30 hexameric capsomers per nucleocapsid (virion composed of 180 protein subunits).
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GENOME

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Monopartite (except Dianthovirus which is bipartite), linear, of 4-5.4 kb, which lacks a cap structure and a poly(A)tail.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Two 5'-proximal ORFs are directly translated to produce the viral constituents of the replicase complex. RdRp is translated through at the end of ORF1 (tombusvirus-like and carmovirus-like), or (Dianthovirus and umbravirus). The downstream genes encoding the , and capsid proteins are translated from subgenomic RNAs. is expressed by of the MVP subgenomic mRNA.
Cap-independent translation is mediated possibly through the interaction between a 3'-cap-independent translation element and a 5'UTR stem-loop.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce the two proteins necessary for RNA synthesis (replication and transcription).
  4. Replication takes place in . A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. The RdRp recognizes internal subgenomic promoters on the negative-sense RNA to transcribe the 3'co-terminal subgenomic RNAs that will generate the capsid and .
  7. Virus in the cytoplasm.
  8. probably mediates virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Viruses of the Tombusviridae family encode proteins acting as . Examples are tombusvirus P19/P20 , aureusvirus , dianthovirus , carmovirus .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

96 entries grouped by strain

Barley yellow dwarf virus (isolate PAV) (BYDV) reference strain

6 entries

Select_allDeselect_all
MCAPS_BYDVP Readthrough protein P3-RTD (P3-P5 readthrough protein) (P72) (Readthrough protein) (RT protein) ...
RDRP_BYDVP Putative RNA-directed RNA polymerase (EC 2.7.7.48)
CAPSD_BYDVP Major capsid protein (Coat protein) (CP)
MVP_BYDVP Movement protein (MP) (17 kDa protein)
ORF6_BYDVP Uncharacterized protein ORF6
ORF7_BYDVP Uncharacterized protein ORF7

Maize chlorotic mottle virus (isolate United States/Kansas/1987) (MCMV) reference strain

5 entries

Select_allDeselect_all
RDRP_MCMVK RNA-directed RNA polymerase (EC 2.7.7.48) (111 kDa protein) (Protein p111) [Cleaved into: Protein ...
CAPSD_MCMVK Capsid protein (Coat protein) (p25)
MP2_MCMVK p7b
MP1_MCMVK Protein p31 [Cleaved into: Movement protein p7a]
P32_MCMVK Uncharacterized protein p32

Panicum mosaic virus (strain United States/Kansas 109S) (PMV) reference strain

5 entries

Select_allDeselect_all
RDRP_PMVK RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p112) [Cleaved into: Protein p48]
MP6_PMVK Putative movement protein p6.6
CAPSD_PMVK Capsid protein (Coat protein) (p26)
MP8_PMVK Probable movement protein p8
P15_PMVK Protein p15

Tobacco necrosis virus (strain A) (TNV-A) reference strain

5 entries

Select_allDeselect_all
CAPSD_TNVA Capsid protein (p30)
RDRP_TNVA RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p82) [Cleaved into: Protein p23]
MP8_TNVA Probable movement protein p8
P6_TNVA Uncharacterized protein p6
P7_TNVA Uncharacterized protein p7

Carnation mottle virus (isolate China/Shanghai) (CarMV) reference strain

4 entries

Select_allDeselect_all
MP1_CARMS Double gene block protein 1 (DGBp1) (Movement protein P7)
MP2_CARMS Double gene block protein 2 (DGBp2) (Movement protein P9)
RDRP_CARMS Probable RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88) [Cleaved into: Protein p28]
CAPSD_CARMS Capsid protein (Coat protein) (p38)

Melon necrotic spot virus (MNSV) reference strain

4 entries

Select_allDeselect_all
RDRP_MNSV RNA-directed RNA polymerase (EC 2.7.7.48) (p89) [Cleaved into: p29]
MP1_MNSV Double gene block protein 1 (DGBp1) (Movement protein P7A)
CAPSD_MNSV Capsid protein (Coat protein) (p42)
MP2_MNSV Double gene block protein 2 (DGBp2) (Movement protein P7B)

Pothos latent virus (isolate Pigeonpea/India) (PoLV) reference strain

4 entries

Select_allDeselect_all
RDRP_POLVP RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p84) [Cleaved into: Protein p25]
MVP_POLVP Movement protein (p27)
CAPSD_POLVP Capsid protein (p40)
P14_POLVP RNA silencing suppressor p14

Tomato bushy stunt virus (strain Cherry) (TBSV) reference strain

4 entries

Select_allDeselect_all
P19_TBSVC RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSVC Movement protein (p22)
CAPSD_TBSVC Capsid protein (Coat protein) (p41)
RDRP_TBSVC RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p92) [Cleaved into: Protein p33]

Turnip crinkle virus (TCV) reference strain

4 entries

Select_allDeselect_all
CAPSD_TCV Capsid protein (Coat protein) (p38)
RDRP_TCV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88) [Cleaved into: Protein p28]
MP1_TCV Double gene block protein 1 (DGBp1) (Movement protein P8)
MP2_TCV Double gene block protein 2 (DGBp2) (Movement protein P9)

Barley yellow dwarf virus (isolate MAV) (BYDV) reference strain

3 entries

Select_allDeselect_all
RDRP_BYDVM Putative RNA-directed RNA polymerase (EC 2.7.7.48)
CAPSD_BYDVM Major capsid protein (Coat protein) (CP)
MVP_BYDVM Movement protein (MP) (17 kDa protein)

Carnation ringspot virus (isolate Lommel) (CRSV) reference strain

3 entries

Select_allDeselect_all
RDRP_CRSVL RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88)
CAPSD_CRSVL Capsid protein (Coat protein)
MP_CRSVL Movement protein (MP)

Groundnut rosette virus (strain MC1) (GRV) reference strain

3 entries

Select_allDeselect_all
ORF3_GRVMC Long-distance movement protein (ORF3 protein)
RDRP_GRVMC RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48)
MVP_GRVMC Movement protein

Oat chlorotic stunt virus (isolate United Kingdom) (OCSV) reference strain

3 entries

Select_allDeselect_all
RDRP_OCSVU RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p84) [Cleaved into: Protein p23]
CAPSD_OCSVU Capsid protein (p48)
P8_OCSVU Uncharacterized protein p8

Red clover necrotic mosaic virus (RCNMV) reference strain

3 entries

Select_allDeselect_all
RDRP_RCNMV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88)
MP_RCNMV Movement protein (MP)
CAPSD_RCNMV Capsid protein (Coat protein)

Cucumber necrosis virus (CNV)

4 entries

Select_allDeselect_all
CAPSD_CNV Capsid protein (Coat protein) (p41)
P19_CNV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_CNV Movement protein (p22)
RDRP_CNV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p92) [Cleaved into: Protein p33]

Cymbidium ringspot virus (CymRSV)

4 entries

Select_allDeselect_all
CAPSD_CRV Capsid protein (Coat protein) (p41)
P19_CRV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_CRV Movement protein (p22)
RDRP_CRV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p92) [Cleaved into: Protein p33]

Tobacco necrosis virus (strain D) (TNV-D)

4 entries

Select_allDeselect_all
RDRP_TNVD RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p82) [Cleaved into: Protein p23]
CAPSD_TNVD Capsid protein (p30)
MP8_TNVD Probable movement protein p8
P6_TNVD Uncharacterized protein p6

Artichoke mottled crinkle virus (AMCV)

3 entries

Select_allDeselect_all
CAPSD_AMCV Capsid protein (Coat protein) (p41)
P19_AMCV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_AMCV Movement protein (p22)

Barley yellow dwarf virus (isolate P-PAV) (BYDV)

3 entries

Select_allDeselect_all
RDRP_BYDVR Putative RNA-directed RNA polymerase (EC 2.7.7.48)
MVP_BYDVR Movement protein (MP) (17 kDa protein)
CAPSD_BYDVR Major capsid protein (Coat protein) (CP)

Carnation mottle virus (CarMV)

3 entries

Select_allDeselect_all
CAPSD_CARMV Capsid protein (Coat protein) (p38)
RDRP_CARMV RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88) [Cleaved into: Protein p28]
MP1_CARMV Double gene block protein 1 (DGBp1) (Movement protein P7)

Tomato bushy stunt virus (strain BS-3) (TBSV)

3 entries

Select_allDeselect_all
CAPSD_TBSVB Capsid protein (Coat protein) (p41)
P19_TBSVB RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSVB Movement protein (p22)

Bean leafroll virus (BLRV)

2 entries

Select_allDeselect_all
CAPSD_BLRV Major capsid protein (Coat protein) (CP)
MVP_BLRV Movement protein (MP) (16 kDa protein)

Tomato bushy stunt virus (strain A23) (TBSV)

2 entries

Select_allDeselect_all
P19_TBSVA RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSVA Movement protein (p22)

Tomato bushy stunt virus (strain B8) (TBSV)

2 entries

Select_allDeselect_all
P19_TBSV8 RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MVP_TBSV8 Movement protein (p22)

Tomato bushy stunt virus (strain Ja6) (TBSV)

2 entries

Select_allDeselect_all
MVP_TBSVJ Movement protein (p22)
P19_TBSVJ RNA silencing suppressor p19 (19 kDa symptom severity modulator)

Tomato bushy stunt virus (strain Ja9) (TBSV)

2 entries

Select_allDeselect_all
MP22_TBSVK Movement protein p22 (p21)
P19_TBSVK RNA silencing suppressor p19 (19 kDa symptom severity modulator)

Tomato bushy stunt virus (strain type) (TBSV)

2 entries

Select_allDeselect_all
P19_TBSVT RNA silencing suppressor p19 (19 kDa symptom severity modulator)
MP22_TBSVT Movement protein p22 (p21)

Carnation Italian ringspot virus (CIRV)

1 entry

P19_CIRV RNA silencing suppressor p19 (19 kDa symptom severity modulator)

Havel river virus (HaRV)

1 entry

P19_HARV RNA silencing suppressor p19 (19 kDa symptom severity modulator)

Pear latent virus (PeLV)

1 entry

P19_PLV RNA silencing suppressor p19 (19 kDa symptom severity modulator)

Pelargonium necrotic spot virus (PeNSV)

1 entry

P19_PENSV RNA silencing suppressor p19 (19 kDa symptom severity modulator)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Angelonia flower break virus taxid:352882

Bermuda grass latent virus taxid:1930269

Calibrachoa mottle virus taxid:204928

Carrot mottle virus taxid:68033

Cherry-associated luteovirus taxid:1912598

Cocksfoot mild mosaic virus taxid:479060

Cowpea mottle virus taxid:12627

Eggplant mottled crinkle virus taxid:270256

Elderberry latent virus taxid:167018

Ethiopian tobacco bushy top virus taxid:1538549

Gompholobium virus A taxid:1884832

Honeysuckle ringspot virus taxid:943272

Japanese iris necrotic ring virus taxid:77344

Maize necrotic streak virus taxid:137556

Maize white line mosaic virus taxid:445227

Moroccan pepper virus taxid:208086

Nootka lupine vein clearing virus taxid:283876

Olive mild mosaic virus taxid:295090

Opium poppy mosaic virus taxid:473784

Pea enation mosaic virus-2 taxid:193120

Pea stem necrosis virus taxid:199361

Pelargonium flower break virus taxid:35291

Pelargonium leaf curl virus taxid:35280

Pelargonium line pattern virus taxid:167019

Pelargonium ringspot virus taxid:167020

Potato necrosis virus taxid:1725329

Rosa rugosa leaf distortion virus taxid:535898

Rose spring dwarf-associated virus taxid:474454

Soybean yellow mottle mosaic virus taxid:578361

Thin paspalum asymptomatic virus taxid:1352511

Trailing lespedeza virus 1 taxid:944580

Yam spherical virus taxid:1421055