Picornaviridae (taxid:12058)

General

VIRION

Non-enveloped, spherical, about 30 nm in diameter, pseudo T=3 icosahedral capsid surrounding the naked RNA genome. The capsid consists of a densely-packed icosahedral arrangement of 60 protomers, each consisting of 4 polypeptides, VP1, VP2, VP3 and VP4. VP4 is located on the internal side of the capsid.

GENOME

Monopartite, linear ssRNA(+) genome of 7.1-8.9 kb, polyadenylated, composed of a single ORF encoding a polyprotein. Viral genomic RNA has a viral protein (VPg) at its 5' end instead of a methylated nucleotide cap structure. The long UTR at the 5' end contains an internal ribosome entry site (IRES). The P1 region encodes the structural polypeptides. The P2 and P3 regions encode the nonstructural proteins associated with replication. The shorter 3' UTR is important in (-)strand synthesis. L is an additional N-terminal leader protein present in some genera that can either be a papain-like cysteine proteinases (genera aphthovirus, erbovirus) or have another function (genera kobuvirus, cardiovirus, teschovirus, sapelovirus, senecavirus).

Enzymes:RNA dependent RNA polymerase, VPG Nucleotidylylase, terminal adenylyltransferase, proteases.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The IRES allows direct translation of the polyprotein. The polyprotein is initially processed by the viral protease(s) into various precursor and mature proteins to yield the structural proteins, replicase, VPg, and a number of proteins that modify the host cell, ultimately leading to cell lysis.

ENZYMES

REPLICATION

CYTOPLASMIC

Attachement of the virus to host receptors mediates endocytosis of the virus into the host cell.
The capsid undergoes a conformational change and releases VP4 that opens a pore in the host endosomal membrane and the viral genomic RNA penetrates into the host cell cytoplasm.
VPg is removed from the viral RNA, which is then translated into a processed polyprotein.
In entero-, rhino-, and aphthoviruses, shutoff of cellular cap-dependent translation through the cleavage of translation initiation factors by viral protease.
Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
New genomic RNA is believed to be packaged into preassembled procapsids.
Cell lysis and virus release.
Maturation of provirions by an unknown host protease.

DB LINKS

Picornaviridae.com

TAXONOMY Group IV; ssRNA positive-strand viruses

Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Pisuviricota
Class:	Pisoniviricetes
Order:	Picornavirales
Family:	Picornaviridae
Genus:	Aphthovirus Aquamavirus Avihepatovirus Ampivirus Avisivirus Cardiovirus Dicipivirus Cosavirus Enterovirus (Includes rhinoviruses) Erbovirus Gallivirus Harkavirus Hepatovirus Hunnivirus Kobuvirus Kunsagivirus Limnipivirus Megrivirus Mischivirus Mosavirus Oscivirus Parechovirus Pasivirus Passerivirus Potamipivirus Rabovirus Rosavirus Sakobuvirus Salivirus Sapelovirus Senecavirus Sicinivirus Teschovirus Torchivirus Tremovirus

VIRUS

Aalivirus A
Aichivirus A
Ampivirus A
Aquamavirus A
Avihepatovirus A
Avisivirus A
Bopivirus A
Cadicivirus A
Cardiovirus A
Cosavirus A
Crohivirus B
Enterovirus C
Erbovirus A
Foot-and-mouth disease virus
Gallivirus A
Harkavirus A
Hepatovirus A
Hunnivirus A
Kunsagivirus A
Limnipivirus A
Megrivirus A
Mischivirus A
Mosavirus A
Orivirus A
Oscivirus A
Parechovirus A
Pasivirus A
Passerivirus A
Potamipivirus A
Rabovirus A
Rosavirus A
Sakobuvirus A
Salivirus A
Sapelovirus A
Senecavirus A
Shanbavirus A
Sicinivirus A
Teschovirus A
Torchivirus A
Tremovirus A
Aichivirus B
Aichivirus C
Aichivirus D
Aichivirus E
Aichivirus F
Avian sapelovirus
Avisivirus B
Avisivirus C
Bovine rhinitis A virus
Bovine rhinitis B virus
Cardiovirus B
Cardiovirus C
Cosavirus B
Cosavirus D
Cosavirus E
Cosavirus F
Crohivirus A
Enterovirus A
Enterovirus B
Enterovirus D
Enterovirus E
Enterovirus F
Enterovirus G
Enterovirus H
Enterovirus I
Enterovirus J
Enterovirus K
Enterovirus L
Equine rhinitis A virus
Hepatovirus B
Hepatovirus C
Hepatovirus D
Hepatovirus E
Hepatovirus F
Hepatovirus G
Hepatovirus H
Hepatovirus I
Kunsagivirus B
Kunsagivirus C
Limnipivirus B
Limnipivirus C
Megrivirus B
Megrivirus C
Megrivirus D
Megrivirus E
Mischivirus B
Mischivirus C
Parechovirus B
Parechovirus C
Parechovirus D
Rhinovirus A
Rhinovirus B
Rhinovirus C
Sapelovirus B

Host

NATURAL HOSTS Vertebrates

TROPISM Enteroviruses: gastrointestinal tract is the primary site of infection.
Hepatoviruses: liver is the primary site of infection.
Rhinoviruses: upper respiratory tract is the primary site of infection.
Cardioviruses: gastrointestinal tract is the primary site of infection.

INTERACTIONS Cell receptors: - FMDV: Integrin alphaV – beta6
EMCV: Vcam1
PV: PVR
CV-A9: Integrin alphaV – beta3, Integrin alphaV – beta6
CV-A21: ICAM-1, CD55
CV-B1 to CV-B6: CXADR
CV-B1, CV-B3 and CV-B5: CD55
E-1 and E-8: Integrin alpha2 – beta1
E-6, E-7, E-11, E-12, E-20 and E-21: CD55
EV-70: alpha2,3-linked sialic, CD55
HHAV: HAVCR1
Major group HRV: ICAM1
Minor group HRV: VLDVR
HRV-87: sialic acids
Host-virus interaction

Ecology and disease

GEOGRAPHY worldwide

ASSOCIATED DISEASES Enteroviruses: paralysis (non-polio and polio-type), summer cold, meningitis, diarrhea.
Aphthoviruses: hand-foot-and-mouth disease (ulcers in mouth, hands and feet). Myocarditis.
Cardioviruses: myocarditis.
Rhinoviruses: common cold.
Hepatoviruses: hepatitis.

TRANSMISSION Enteroviruses: fecal-oral and respiratory routes.
Rhinoviruses: direct contact with infected respiratory secretions.
Hepatoviruses: fecal-oral.
Aphthoviruses: direct or indirect contact. Airborne.
Cardioviruses: ingestion of virus-contaminated material.

VACCINE Poliovirus, hepatitis A virus, foot and mouth disease virus.

ANTIVIRAL DRUGS Pleconaril

Host-virus interaction

Apoptosis modulation

Picornaviruses modulate host apoptosis .

Poliovirus infection activates the apoptotic pathway, involving mitochondrial damage, cytochrome c efflux, and consecutive activation of caspases (caspase-3 caspase and -9) , whereas antiapoptotic activity has been attributed to cardiovirus leader protein .

Modulation of apoptosis depends on the host cell-type and on the time the infection because of the presence of viral pro- and anti-apoptotic factors respectively at the beginning and at the end of the infectious cycle .

Autophagy modulation

Picornaviruses subvert the cell autophagic pathway to facilitates viral infection :

- Human rhinovirus 2 and EMCV activates the autophagic pathway
- Foot-and-mouth disease virus utilizes the autophagic pathway
- Coxsackievirus and poliovirus infection induces autophagy-like vesicles

Innate immune response inhibition

Picornaviruses inhibit the host IFN-mediated response by inactivating either MDA-5, RIG-I, MAVS or IRF-3:
- HAV cleaves and inhibits MAVS
- Coxsackievirus B3 cleaves and inhibits MAVS
- Enteroviruses and cardiviruses cleave and inhibit RIG-I
-Poliovirus cleaves and inhibits MDA-5
- Mengovirus and foot-and-mouth disease virus leader proteins inhibit IRF-3 .

Picornaviruses inhibit Toll-like receptor 3 mediated antiviral response as well:

- Coxsackievirus B 3C, HAV and enterovirus 71 proteases 3C cleave TRIF .

Host gene expression shutoff by virus

Picornaviruses inhibit host translation by cleaving various translation factors such as PABP (FMDV, poliovirus and coxsackievirus) , eIF3a, eIF3b (FMDV) , eIF5B and activating 4E-BP1 .

Poliovirus also inhibits host transcription by cleaving the TATA-binding protein .

Some enteroviruses or cardioviruses inhibit host mRNA export as well.

GENERAL Back to picornaviridae page

NATURAL HOSTS Vertebrates

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

95 entries grouped by strain

reorder by protein

Encephalomyocarditis virus (strain Rueckert) (EMCV) reference strain

2 entries

Poliovirus type 1 (strain Mahoney) reference strain

2 entries

POLG_POL1M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1AL2; 1AR6; 1AR7; 1AR8; 1AR9; 1ASJ; 1DGI; 1FPT; 1HXS; 1L1N; 1NG7; 1NN8; 1PO1; 1PO2; 1POV; 1RA6; 1RA7; 1RAJ; 1RDR; 1TQL; 1VBD; 1XYR; 2BBL; 2BBP; 2IJD; 2IJF; 2ILY; 2ILZ; 2IM0; 2IM1; 2IM2; 2IM3; 2PLV; 3EPC; 3IYB; 3IYC; 3J3O; 3J3P; 3J48; 3J8F; 3J9F; 3JBC; 3JBD; 3JBE; 3JBF; 3JBG; 3OL7; 4DCD; 4K4S; 4K4T; 4K4U; 4K4V; 4K4W; 4NLO; 4NLP; 4NLQ; 4NLR; 4NLS; 4NLT; 4NLU; 4NLV; 4NLW; 4NLX; 4NLY; 4R0E; 5KTZ; 5KU0; 5KU2; 5KWL; 5Z3Q; 6HLV; 6P9O; 6P9W; 6PSZ; 9FQ2

ORF2P_POL1M ORF2p protein

Aichi virus (strain Human/A846/88/1989) (AiV) (Aichi virus (strain A846/88)) reference strain

1 entry

Avian encephalomyelitis virus (strain Calnek vaccine) (AEV) reference strain

1 entry

Cosavirus A (isolate Human/Pakistan/0553/-) (HCoSV-A) reference strain

1 entry

Foot-and-mouth disease virus serotype O (FMDV) reference strain

1 entry

Human hepatitis A virus genotype IB (isolate HM175) (HHAV) (Human hepatitis A virus (isolate Human/Australia/HM175/1976)) reference strain

1 entry

Human parechovirus 2 (strain Williamson) (HPeV-2) (Echovirus 23) reference strain

1 entry

Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain

1 entry

Salivirus A (isolate Human/Nigeria/NG-J1/2007) (SV-A) reference strain

1 entry

Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain

1 entry

Coxsackievirus B3 (strain Nancy)

2 entries

POLG_CXB3N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

2VB0; 2ZTX; 2ZTY; 2ZTZ; 2ZU1; 2ZU3; 3CDU; 3CDW; 4WFX; 4WFY; 4WFZ; 4Y2A; 6S3A; 6T3W; 7LMS; 7QUW; 7W0Q; 7W0S; 7W0T; 8S6F; 8Y2T

ORF2P_CXB3N ORF2p protein

Encephalomyocarditis virus

2 entries

POLG_EMCV Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

8X3V

ALT2B_EMCV Protein 2B*

Human enterovirus 71 (strain USA/BrCr/1970) (EV71) (EV-71)

2 entries

Mengo encephalomyocarditis virus

2 entries

POLG_ENMGO Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1MEC; 2M7Y; 2MEV; 2MMH; 2MMI; 2MMK; 2MML; 4NYZ; 4NZ0; 4Y2C; 4Y3C; 7BNY; 7NWT

ALT2B_ENMGO Protein 2B*

Theiler's murine encephalomyelitis virus (strain DA) (TMEV)

2 entries

POLG_TMEVD Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1TME; 1TMF

SMALL_TMEVD Protein L*

Theiler's murine encephalomyelitis virus (strain GDVII) (TMEV)

2 entries

POLG_TMEVG Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

7NBV

ALT2B_TMEVG Protein 2B*

Avian encephalomyelitis virus (strain L2Z) (AEV)

1 entry

Avian encephalomyelitis virus (strain Van Reokel) (AEV)

1 entry

Bovine enterovirus (strain VG-5-27) (BEV)

1 entry

Coxsackievirus A16 (strain G-10)

1 entry

POLG_CX16G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

7H2T; 7H2U; 7H2V; 7H2W; 7H2X; 7H2Y; 7H2Z; 7H30; 7H31; 7H32; 7H33; 7H34; 7H35; 7H36; 7H37; 7H38; 7H39; 7H3A; 7H3B; 7H3C; 7H3D; 7H3E; 7H3F; 7H3G; 7H3H; 7H3I; 7H3J; 7H3K; 7H3L; 7H3M; 7H3N; 7H3O; 7H3P; 7H3Q; 7H3R; 7H3S; 7H3T; 7H3U; 7H3V; 7H3W; 7H3X; 7H3Y; 7H3Z; 7H40; 7H41; 7H42; 7H43; 7H44; 7H45; 7H46; 7H47; 7H48; 7H49; 7H4A; 7H4B; 7H4C; 7H4D; 7H4E; 7H4F; 7H4G; 7H4H; 7H4I; 7H4J; 7H4K; 7H4L; 7H4M; 7H4N; 7H4O; 7H4P; 7H4Q; 7H4R; 7H4S; 7H4T; 7H4U; 7H4V; 7H4W; 7H4X; 7H4Y; 7H4Z; 7H50; 7H51; 7H52; 7H53; 7H54; 7H55; 7HOC; 7HOD; 7HOE; 7HOF; 7HOG; 7HOH; 7HOI; 7HUF; 7HUG; 7HUH; 7HUI; 7HUJ; 7HUK; 7HUL; 7HUN; 7HUO; 7HUP; 7HUQ; 7HUR; 7HUS; 7HUT; 7HUU; 7HUV; 7HUW; 7HUX; 7HUY; 7HUZ; 7HV0; 7HV1; 7HV2; 7HV3; 7HV4; 7HV5; 7HV6; 7HV7; 7HV8; 7HV9; 7HVA; 7HVB; 7HVC; 7HVD; 7HVE; 7HVF; 7HVG; 7HVH; 7HVI; 7HVJ; 7HVK; 7HVL; 7HVM; 7HVN; 7HVO; 7HVQ; 7HVR; 7HVS; 7HVT; 7HVU; 7HVV; 7HVW; 7HVX; 7HVY; 7HVZ; 7HW0; 7HW1; 7HW3; 7HW4; 7HW5; 7HW6; 7HW8; 7HW9; 7HWA; 7HWB; 7HWC; 7HWD; 7HWE; 7HWF; 7HWG; 7HWH; 7HWI; 7HWJ; 7HWK; 7HWL; 7HWM; 7HWN; 7HWO; 7HWP; 7HWQ; 7HWR; 7HWS; 7HWT; 7HWU; 7HWV; 7HWW; 7HWX; 7HWY; 7HWZ; 7HX0; 7HX1; 7HX2; 7HX3; 7HX4; 7HX5; 7HX6; 7HX7; 7HX8; 7HX9; 7HXA; 7HXB; 7HXC; 7HXD; 7HXE; 7HXF; 7HXG; 7HXH; 7HXI; 7HXJ; 7HXK; 7HXL; 7HXM; 7HXN; 7HXO; 7HXP; 7HXQ; 7HXR; 7HXS; 7HXT; 7HXU; 7HXV; 7HXW; 7HXX; 7HXY; 7HXZ; 7HY0; 7HY1; 7HY2; 7HY3; 7HY4; 7HY5; 7HY6; 7HY7; 7HY8; 7HY9; 7HYA; 7HYB; 7HYC; 7HYD; 7HYE; 7HYF; 7HYG; 7HYH; 7HYI; 7HYJ; 7HYK; 7HYL; 7HYM; 7HYN; 7HYO; 7HYP; 7HYQ; 7HYR; 7HYS; 7HYT; 7HYU; 7HYV; 7HYW; 7HYX; 7HYY; 7HYZ; 7HZ0; 7HZ1; 7HZ2; 7HZ3; 7HZ4; 7HZ5; 7HZ6; 7HZ7; 7HZ8; 7HZ9; 7HZA; 7HZB; 7HZC; 7HZD; 7HZE; 7HZF; 7HZG; 7HZH; 7HZI; 7HZJ; 7HZK; 7HZL; 7HZM; 7HZN; 7HZO; 7HZP; 7HZQ; 7HZR; 7HZS; 7HZT; 7HZU; 8POA

Coxsackievirus A16 (strain Tainan/5079/98)

1 entry

Coxsackievirus A21 (strain Coe)

1 entry

Coxsackievirus A24 (strain EH24/70)

1 entry

Coxsackievirus A9 (strain Griggs)

1 entry

Coxsackievirus B1 (strain Japan)

1 entry

Coxsackievirus B2 (strain Ohio-1)

1 entry

Coxsackievirus B3 (strain Woodruff)

1 entry

Coxsackievirus B4 (strain E2)

1 entry

Coxsackievirus B4 (strain JVB / Benschoten / New York/51)

1 entry

Coxsackievirus B5 (strain Peterborough / 1954/UK/85)

1 entry

Coxsackievirus B6 (strain Schmitt)

1 entry

Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)

1 entry

Echovirus 11 (strain Gregory)

1 entry

Echovirus 12 (strain Travis)

1 entry

Echovirus 30 (strain Bastianni)

1 entry

Echovirus 5 (strain Noyce)

1 entry

Echovirus 6 (strain Charles)

1 entry

Echovirus 9 (strain Barty)

1 entry

Echovirus 9 (strain Hill)

1 entry

Encephalomyocarditis virus (strain emc-b nondiabetogenic)

1 entry

Encephalomyocarditis virus (strain emc-d diabetogenic)

1 entry

Foot-and-mouth disease virus (isolate -/Azerbaijan/A22-550/1965 serotype A) (FMDV)

1 entry

Foot-and-mouth disease virus (isolate -/Brazil/C3Indaial/1971 serotype C) (FMDV)

1 entry

Foot-and-mouth disease virus (isolate -/Germany/A5Westerwald/1951 serotype A) (FMDV)

1 entry

Foot-and-mouth disease virus (isolate -/Germany/C1Oberbayen/1960 serotype C) (FMDV)

1 entry

Foot-and-mouth disease virus (isolate -/Spain/S8c1SantaPau/1970 serotype C) (FMDV)

1 entry

Foot-and-mouth disease virus (isolate Bovine/Brazil/A24Cruzeiro/1955 serotype A) (FMDV)

1 entry

Foot-and-mouth disease virus (isolate Bovine/United Kingdom/A12Valle119/1932 serotype A) (FMDV)

1 entry

Foot-and-mouth disease virus (isolate Swine/Taiwan/OTai/1997 serotype O) (FMDV)

1 entry

Foot-and-mouth disease virus (strain A10/Holland/1961 serotype A) (FMDV)

1 entry

Foot-and-mouth disease virus serotype Asia-1 (FMDV)

1 entry

Foot-and-mouth disease virus serotype SAT-2 (FMDV)

1 entry

Human enterovirus 70 (strain J670/71) (EV70) (EV-70)

1 entry

Human enterovirus 71 (EV71) (EV-71)

1 entry

Human enterovirus 71 (strain 7423/MS/87) (EV71) (EV-71)

1 entry

Human enterovirus D68 (EV68) (EV-68)

1 entry

POLG_HED68 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

4WM7; 4WM8; 5BNN; 5BNO; 5BNP; 6HLN; 6HMV; 7GNV; 7GNW; 7GNX; 7GNY; 7GNZ; 7GO0; 7GO1; 7GO2; 7GO3; 7GO4; 7GO5; 7GO6; 7GO7; 7GO8; 7GO9; 7GOA; 7GOB; 7GOC; 7GOD; 7GOE; 7GOF; 7GOG; 7GOH; 7GOI; 7GOJ; 7GOK; 7GOL; 7GOM; 7GON; 7GOO; 7GOP; 7GOQ; 7GOR; 7GOS; 7GOT; 7GOU; 7GOV; 7GOW; 7GOX; 7GOY; 7GOZ; 7GP0; 7GP1; 7GP2; 7GP3; 7GP4; 7GP5; 7GP6; 7GP7; 7GP8; 7GP9; 7GPA; 7GPC; 7GPD; 7GPE; 7GPF; 7GPG; 7GPH; 7GPI; 7GPJ; 7GPK; 7GPL; 7GPM; 7GPN; 7GPO; 7GPP; 7GPQ; 7GPR; 7GPS; 7GPT; 7GPU; 7GPV; 7GPW; 7GPX; 7GPY; 7GPZ; 7GQ0; 7GQ1; 7GQ2; 7GQ3; 7GQ4; 7GQ5; 7GQ6; 7GQ7; 7GQ8; 7GQ9; 7GQA; 7GQB; 7GQC; 7GQD; 7GQE; 7GQF; 7GQG; 7GQH; 7GQI; 7GQJ; 7GQK; 7GQL; 7GQM; 7GQN; 7GQO; 7GQP; 7GQQ; 7GQR; 7JRE; 8CNX

Human hepatitis A virus genotype IA (isolate GBM) (HHAV) (Human hepatitis A virus (isolate Human/Germany/GBM/1976))

1 entry

Human hepatitis A virus genotype IA (isolate H2) (HHAV) (Human hepatitis A virus (isolate Human/China/H2/1982))

1 entry

Human hepatitis A virus genotype IA (isolate LA) (HHAV) (Human hepatitis A virus (isolate Human/Northern California/LA/1974))

1 entry

Human hepatitis A virus genotype IB (isolate MBB) (HHAV) (Human hepatitis A virus (isolate Human/Northern Africa/MBB/1978))

1 entry

Human hepatitis A virus genotype IIA (isolate CF-53) (HHAV) (Human hepatitis A virus (isolate Human/France/CF-53/1979))

1 entry

Human hepatitis A virus genotype IIB (isolate SLF88) (HHAV) (Human hepatitis A virus (isolate Human/Sierra Leone/SLF88/1988))

1 entry

Human hepatitis A virus genotype IIIA (isolate NOR-21) (HHAV) (Human hepatitis A virus (isolate Human/Norway/NOR-21/1998))

1 entry

Human hepatitis A virus genotype IIIB (isolate HAJ85-1) (HHAV) (Human hepatitis A virus (isolate Human/Japan/HAJ85-1/1985))

1 entry

Human klassevirus 1 (HKV-1)

1 entry

Human parechovirus 1 (strain Harris) (HPeV-1) (Echovirus 22)

1 entry

Human parechovirus 5 (strain CT86-6760) (HPeV-5) (Echovirus 23)

1 entry

Human rhinovirus 14 (HRV-14)

1 entry

POLG_HRV14 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1D3I; 1HRI; 1HRV; 1K5M; 1NA1; 1NCQ; 1R08; 1R09; 1RMU; 1RUC; 1RUD; 1RUE; 1RUF; 1RUG; 1RUH; 1RUI; 1RUJ; 1RVF; 1VRH; 1XR5; 2B0F; 2HWB; 2HWC; 2IN2; 2R04; 2R06; 2R07; 2RM2; 2RMU; 2RR1; 2RS1; 2RS3; 2RS5; 4PDW; 4RHV; 5W3E; 5W3L; 5W3M; 5W3O; 6HLT; 6KYZ; 6KZ0

Human rhinovirus 16 (HRV-16)

1 entry

Human rhinovirus 1A (HRV-1A)

1 entry

Human rhinovirus 1B (HRV-1B)

1 entry

Human rhinovirus 2 (HRV-2)

1 entry

Human rhinovirus 3 (HRV-3)

1 entry

Human rhinovirus C (strain C15) (HRV-C15)

1 entry

Ljunganvirus 1 (LV) (Ljungan virus 1)

1 entry

Poliovirus type 1 (strain Sabin)

1 entry

Poliovirus type 2 (strain Lansing)

1 entry

Poliovirus type 2 (strain W-2)

1 entry

Poliovirus type 3 (strain 23127)

1 entry

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

1 entry

Porcine enterovirus 9 (strain UKG/410/73)

1 entry

Saffold virus (SafV) (Human TMEV-like virus-Saffold)

1 entry

Simian hepatitis A virus genotype V (isolate AGM-27) (SHAV) (Simian hepatitis A virus (isolate Cercopithecus/Kenya/AGM-27/1985))

1 entry

Swine vesicular disease virus (strain H/3 '76) (SVDV)

1 entry

Swine vesicular disease virus (strain UKG/27/72) (SVDV)

1 entry

Theiler's murine encephalomyelitis virus (strain BeAn 8386) (TMEV)

1 entry

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna

(ModelArchive).

hepatovirus B1 taxid:1708572

Protein	ModelArchive
Genome polyprotein	ma-jd-viral-30863