Orthonairovirus (taxid:1980517)
VIRION

Enveloped, spherical. Diameter from 80 to 120nm.
GENOME
Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins.
GENE EXPRESSION
The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. These are capped by L protein during synthesis using cap snatching .
ENZYMES
- RNA-dependent RNA polymerase [L]
- Polynega-type cap snatching [L]
- Ubiquitinyl hydrolase (Peptidase C87) [L]
REPLICATION
CYTOPLASMIC
- Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
- Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
- Transcription, viral mRNAs are capped in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
- The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.
Host-virus interaction
Inhibition of host innate immunity
The nairovirus L protein contains an ovarian tumor domain-containing deubiquitinase that targets activated RIG-I
to control innate immune signaling.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)11 entries grouped by strain
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4 entries
Dugbe virus (isolate ArD44313) (DUGV) reference strain
3 entries
Hazara virus (isolate JC280) reference strain
2 entries
Crimean-Congo hemorrhagic fever virus (isolate C68031) (CCHFV)
1 entry
Dugbe virus
1 entry
Huangpi Tick Virus 1 taxid:1608047
Protein | ModelArchive |
M polyprotein | ma-jd-viral-58950 |
Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-00520 |
Kasokero virus taxid:1712570
Protein | ModelArchive |
Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-00517 |
Leopards Hill virus taxid:1381104
Protein | ModelArchive |
Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-00526 |
Tacheng Tick Virus 1 taxid:1608083
Protein | ModelArchive |
M polyprotein | ma-jd-viral-58960 |
Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-00529 |
Tofla virus taxid:1615758
Protein | ModelArchive |
M polyprotein | ma-jd-viral-58948 |
Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-00518 |
Wenzhou Tick Virus taxid:1608094
Protein | ModelArchive |
M polyprotein | ma-jd-viral-58949 |
Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-00532 |
Yogue virus taxid:1712572
Protein | ModelArchive |
Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-00523 |