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Orthonairovirus (taxid:1980517)

Orthonairovirus is a genus of ssRNA- viruses in the Nairoviridae family that infect vertebrates and are transmitted by arthropods (arbovirus). In humans, these viruses can cause hemorrhagic fever.

VIRION

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Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

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Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. These are capped by L protein during synthesis using .

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is into vesicles in the host cell.
  2. of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. , viral mRNAs are capped in the cytoplasm.
  4. presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids at Golgi apparatus, releasing the virion by exocytosis.

Host-virus interaction

Inhibition of host innate immunity

The nairovirus L protein contains an ovarian tumor domain-containing deubiquitinase that to control innate immune signaling.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

11 entries grouped by strain

Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) reference strain

4 entries

Select_allDeselect_all
NCAP_CCHFI Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)
L_CCHFI RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GP_CCHFI Envelopment polyprotein (M polyprotein) [Cleaved into: Mucin-like variable region; GP38; ...
NSS_CCHFI Non-structural protein (NSs)

Dugbe virus (isolate ArD44313) (DUGV) reference strain

3 entries

Select_allDeselect_all
L_DUGBA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GP_DUGBA Envelopment polyprotein (M polyprotein) [Cleaved into: Mucin-like variable region; GP38; ...
NCAP_DUGBA Nucleoprotein (Nucleocapsid protein) (Protein N)

Hazara virus (isolate JC280) reference strain

2 entries

Select_allDeselect_all
GP_HAZVJ Envelopment polyprotein (M polyprotein) [Cleaved into: GP38; Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_HAZVJ Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

Crimean-Congo hemorrhagic fever virus (isolate C68031) (CCHFV)

1 entry

NCAP_CCHFV Nucleoprotein (Nucleocapsid protein) (Protein N)

Dugbe virus

1 entry

NCAP_DUGBV Nucleoprotein (Nucleocapsid protein) (Protein N)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

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