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Lyssavirus (taxid:11286)

Lyssavirus is a genus of ssRNA- viruses in the family Rhabdoviridae that infect neurons of mammals. Rabies virus (RabV) infections in humans are associated with Rabies fatal encephalitis.

VIRION

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Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

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Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by .

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. of the viral G glycoproteins to mediates of the virus into the host cell.
  2. of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. , viral mRNAs are capped and polyadenylated by in the cytoplasm.
  4. presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and occurs at the plasma membrane, releasing new virions.
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TAXONOMY
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Subphylum: Haploviricotina
Class: Monjiviricetes
Order: Mononegavirales
Family:
Genus: Lyssavirus
VIRUS

Aravan lyssavirus
 Australian bat lyssavirus
 Bokeloh bat lyssavirus
 Duvenhage lyssavirus
 European bat 1 lyssavirus
 European bat 2 lyssavirus
 Gannoruwa bat lyssavirus
 Ikoma lyssavirus
 Irkut lyssavirus
 Khujand lyssavirus
 Lagos bat lyssavirus
 Lleida bat lyssavirus
 Mokola lyssavirus
 Shimoni bat lyssavirus
 West Caucasian bat lyssavirus
REFERENCE STRAIN Rabies virus
Sequence | Genome assembly | Proteome
Mokola virus
Sequence | Genome assembly | Proteome
Australian bat lyssavirus
Sequence | Genome assembly | Proteome
European bat lyssavirus 1
Sequence | Genome assembly | Proteome
European bat lyssavirus 2
Sequence | Genome assembly | Proteome

Host

HOST Primary host: carnivorous mammals.
Dead end, occasional host: Human, Cow, non carnivorous mammals.
CELL TROPISM Neurons
INTERACTIONS Cell receptors: RABV: , , nAChR
Host-virus interaction

Ecology and Disease

GEOGRAPHY Worldwide except for Australia, Antarctica, England, New-Zealand, Japan, Island.
ASSOCIATED DISEASES fatal encephalitis
TRANSMISSION , animal bite
VACCINE RABV
ANTIVIRAL DRUGS None

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in
Rabies phosphoprotein may

Inhibition of host type I interferon signaling

Rabies phosphoprotein may antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a by inhibiting Vbeta T-Cell repertoire

.

NATURAL HOSTS Vertebrates
TROPISM Rabies virus replicates in neurons
ASSOCIATED DISEASES Rabies virus: fatal encephalitis
TRANSMISSION Rabies virus: , animal bite.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

108 entries grouped by strain

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

5 entries

Select_allDeselect_all
L_ABLVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVB Glycoprotein
MATRX_ABLVB Matrix protein (Phosphoprotein M2)
NCAP_ABLVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

5 entries

Select_allDeselect_all
PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)
L_EBLV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_EBLV1 Glycoprotein
NCAP_EBLV1 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_EBLV1 Matrix protein

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

5 entries

Select_allDeselect_all
PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)
GLYCO_EBLV2 Glycoprotein
L_EBLV2 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_EBLV2 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_EBLV2 Matrix protein

Mokola virus (MOKV) reference strain

5 entries

Select_allDeselect_all
L_MOKV Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)

pdb 2WZL

NCAP_MOKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_MOKV Matrix protein (Phosphoprotein M2)
GLYCO_MOKV Glycoprotein

pdb 6TMR

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

5 entries

Select_allDeselect_all
PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)

pdb 3OA1

GLYCO_RABVP Glycoprotein

pdb 7U9G; 8A1E

L_RABVP Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
NCAP_RABVP Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVP Matrix protein (Phosphoprotein M2)

West Caucasian bat virus (WCBV) reference strain

4 entries

Select_allDeselect_all
GLYCO_WCBV Glycoprotein
MATRX_WCBV Matrix protein (Phosphoprotein M2)
PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)
NCAP_WCBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain PM1503/AVO1) (RABV)

6 entries

Select_allDeselect_all
PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)

pdb 8FUQ

L_RABVA Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
NCAP_RABVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVA Glycoprotein
MATRX_RABVA Matrix protein (Phosphoprotein M2)
C_RABVA Putative uncharacterized protein C

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

5 entries

Select_allDeselect_all
L_ABLVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVH Glycoprotein
MATRX_ABLVH Matrix protein (Phosphoprotein M2)
NCAP_ABLVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain China/DRV) (RABV)

5 entries

Select_allDeselect_all
L_RABVD Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVD Glycoprotein
MATRX_RABVD Matrix protein (Phosphoprotein M2)
NCAP_RABVD Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain China/MRV) (RABV)

5 entries

Select_allDeselect_all
PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)

pdb 3L32

L_RABVR Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVR Glycoprotein
MATRX_RABVR Matrix protein (Phosphoprotein M2)
NCAP_RABVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain ERA) (RABV)

5 entries

Select_allDeselect_all
GLYCO_RABVE Glycoprotein

pdb 3NFK

PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)
L_RABVE Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVE Matrix protein (Phosphoprotein M2)
NCAP_RABVE Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

pdb 2GTT

Rabies virus (strain HEP-Flury) (RABV)

5 entries

Select_allDeselect_all
L_RABVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVH Glycoprotein
MATRX_RABVH Matrix protein (Phosphoprotein M2)
NCAP_RABVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain India) (RABV)

5 entries

Select_allDeselect_all
L_RABVI Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVI Glycoprotein
NCAP_RABVI Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVI Matrix protein (Phosphoprotein M2)

Rabies virus (strain Nishigahara RCEH) (RABV)

5 entries

Select_allDeselect_all
L_RABVN Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVN Glycoprotein
PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)

pdb 7C20; 7T5G; 7T5H

MATRX_RABVN Matrix protein (Phosphoprotein M2)
NCAP_RABVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain SAD B19) (RABV)

5 entries

Select_allDeselect_all
PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)

pdb 6UEB

MATRX_RABVS Matrix protein (Phosphoprotein M2)
GLYCO_RABVS Glycoprotein
L_RABVS Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...

pdb 6UEB

NCAP_RABVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

5 entries

Select_allDeselect_all
L_RABVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVB Glycoprotein
MATRX_RABVB Matrix protein (Phosphoprotein M2)
NCAP_RABVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Aravan virus (ARAV)

4 entries

Select_allDeselect_all
PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)
GLYCO_ARAV Glycoprotein
MATRX_ARAV Matrix protein (Phosphoprotein M2)
NCAP_ARAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Irkut virus (IRKV)

4 entries

Select_allDeselect_all
PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_IRKV Glycoprotein
MATRX_IRKV Matrix protein (Phosphoprotein M2)
NCAP_IRKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Khujand virus (KHUV)

4 entries

Select_allDeselect_all
PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)
GLYCO_KHUV Glycoprotein
MATRX_KHUV Matrix protein (Phosphoprotein M2)
NCAP_KHUV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Lagos bat virus (LBV)

4 entries

Select_allDeselect_all
PHOSP_LBV Phosphoprotein (Protein P) (Protein M1)
MATRX_LBV Matrix protein

pdb 2W2S

NCAP_LBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_LBV Glycoprotein

Rabies virus (strain CVS-11) (RABV)

4 entries

Select_allDeselect_all
PHOSP_RABVC Phosphoprotein (Protein P) (Protein M1)

pdb 1VYI; 8B8V

GLYCO_RABVC Glycoprotein

pdb 8R40

MATRX_RABVC Matrix protein (Phosphoprotein M2)
NCAP_RABVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

pdb 8B8V

Duvenhage virus (DUVV)

3 entries

Select_allDeselect_all
PHOSP_DUVV Phosphoprotein (Protein P) (Protein M1)

pdb 7C21

NCAP_DUVV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_DUVV Glycoprotein

Rabies virus (isolate Fox/Ontario/1991) (RABV)

1 entry

NCAP_RABVF Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (isolate Human/Algeria/1991) (RABV)

1 entry

GLYCO_RABVT Glycoprotein

Rabies virus (isolate Skunk/Ontario/1991) (RABV)

1 entry

NCAP_RABVU Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Rabies virus (strain PM) (RABV)

1 entry

PHOSP_RABVM Phosphoprotein (Protein P) (Protein M1)

Rabies virus (strain Vnukovo-32) (RABV)

1 entry

GLYCO_RABVV Glycoprotein
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Australian bat lyssavirus (isolate Bat/AUS/1996) taxid:446561

Duvenhage virus taxid:38767

European bat lyssavirus 1 taxid:57482

Protein ModelArchive

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) taxid:453115

European bat lyssavirus 2 taxid:57483

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) taxid:453116

Gannoruwa bat lyssavirus taxid:1846259

Ikoma lyssavirus taxid:1167696

Lagos bat virus taxid:38766

Lleida bat lyssavirus taxid:1213198

Lyssavirus bokeloh taxid:1072176

Lyssavirus shimoni taxid:746543

Mokola virus taxid:12538

Rabies virus taxid:11292

Protein ModelArchive

Rabies virus (strain Pasteur vaccins / PV) taxid:103929