H1N1 subtype (taxid:114727)

General

VIRION

Molecular biology

Enveloped. Usually rounded but can be filamentous. The virions are 80-120 nm in diameter.

GENOME

Segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP). Contains 8 segments coding for 12-14 proteins depending on strains. Segments size range from 890 to 2,341nt. Genome total size is 13.5Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap cleaved from cellular mRNAS by Cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. MP and NS mRNA can be alternately spliced, giving rise to mRNA coding for M2 and NEP proteins. Some strains can express M42 from the M segment . PB1 mRNA encode three proteins by leaky scanning: PB1, N40 and PB1-F2 . Pa-X protein is translated by ribosomal frameshift on the PA gene. Leaky scanning may produces N-truncated PA proteins, namely PA-N155 and PA-N182 . PB2-S1 would be an alternative splicing from PB2 gene (unpublished 1/1/15).

ENZYMES

REPLICATION

NUCLEUS

Virus attaches to sialic acid receptor though HA protein and is endocytosed by clathrins in the host cell.
endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
Replication of genomic segments.
High level of M1 protein induces genomes segments export from nucleus by NEP protein.
Virus assembly and budding occurs at the plasma membrane.

DB LINKS

Seasonal Influenza:

TAXONOMY Group V: Negative sense ssRNA viruses

Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Negarnaviricota
Subphylum:	Polyploviricotina
Class:	Insthoviricetes
Order:	Articulavirales
Family:	Orthomyxoviridae
Genus:	Influenzavirus A
Subtype:	H1N1

VIRUS

REFERENCE STRAIN Influenza A virus A/Puerto Rico/8/34 (H1N1)
Sequence: RNA1 RNA2 RNA3 RNA4 RNA5 RNA6 RNA7 RNA8 | Genome assembly | Proteome

Host

HOST Aquatic birds, Human, Pig, Horse, Seals

CELL TROPISM epithelial respiratory cells

INTERACTIONS Cell receptors: Sialic acids

(-> SugarBindDB) INTERACTIONS Host-virus interaction

Ecology and disease

GEOGRAPHY Worldwide, more common in winter

ASSOCIATED DISEASES Acute febrile respiratory tract infection

TRANSMISSION Mammals: Respiratory
Zoonosis, animal contact
Birds: Fecal-oral route from contaminated water

VACCINE Killed vaccine against annual strains of both influenza A and B

ANTIVIRAL DRUGS M2 ion channel inhibitor:
Amantidine, Rimantadine:
Neuraminidase inhibitor:
Zanamivir, Oseltamivir (Tamiflu), Peramivir
RNA-dependent RNA polymerase
Experimental: Favipiravir

Host-virus interaction

Innate immune response inhibition

Influenza A virus inhibits the cascade leading to production of interferon-beta by targeting different cellular proteins. NS1 inhibits host RIG-I activation upon recognition of viral RNA, and subsequent induction of IFN-beta expression.

PB1-F2 inhibits host MAVS activation.

Host protein shutoff

NS1 induces host gene expression shutoff by inducing host mRNA suppression through polyadenlyation inhibition. The viral mRNA are not affected because their polyA tail is generated by polymerase stuttering.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

340 entries grouped by strain

reorder by protein

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

13 entries

PB2_I34A1 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

2ZTT; 3A1G; 3CW4; 3WI0; 3WI1; 4ENF; 4J2R; 4U6O; 7JYW; 7JYX

RDRP_I34A1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

2ZNL; 2ZTT; 3A1G; 9IM6

PA_I34A1 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

2ZNL; 4YYL; 4ZHZ; 4ZI0; 4ZQQ; 5FDD; 5FDG; 5I13; 5JHT; 5JHV; 7XGC

HEMA_I34A1 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

1RU7; 1RVX; 1RVZ

NCAP_I34A1 Nucleoprotein (Nucleocapsid protein) (Protein N)

2BST; 2WFS; 4NQV; 4ZDU; 5NPZ; 5NQ3; 5V5O

NRAM_I34A1 Neuraminidase (EC 3.2.1.18)

6WZY; 6X00

M1_I34A1 Matrix protein 1 (M1)

1AA7; 1EA3; 1HHI; 2VLL; 2VLR; 3VDX; 4D9J; 4IQ4; 4ITV; 4IVJ; 4QES; 4QF0; 4QFF; 5CQE; 5E6I; 5EUO; 5ISZ; 5JHD; 5TEZ; 6Z5L; 7JM3

NS1_I34A1 Non-structural protein 1 (NS1) (NS1A)

2GX9; 2ZKO; 3L4Q; 3O9Q; 3O9R; 3O9S; 3O9T; 3O9U; 3RVC; 5NT1; 5NT2

M2_I34A1 Matrix protein 2 (Proton channel protein M2)

5DLM

PB1F2_I34A1 Protein PB1-F2

2HN8; 3BUY

NEP_I34A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

1PD3

PAX_I34A1 Protein PA-X

PB2S1_I34A1 PB2-S1

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))

13 entries

M2_I18A0 Matrix protein 2 (Proton channel protein M2)

NRAM_I18A0 Neuraminidase (EC 3.2.1.18)

3B7E; 3BEQ; 3CYE; 6D96; 6LXI; 8E6J; 8E6K

PA_I18A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

7NHA; 7NHC; 7NHX; 7NI0; 7NIK; 7NIL; 7NIR; 7NIS; 7NJ3; 7NJ4; 7NJ5; 7NJ7; 7NK1; 7NK2; 7NK4; 7NK6; 7NK8; 7NKA; 7NKC; 7NKI; 7NKR; 8R60; 8R65

RDRP_I18A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

7NHA; 7NHC; 7NHX; 7NI0; 7NIK; 7NIL; 7NIR; 7NIS; 7NJ3; 7NJ4; 7NJ5; 7NJ7; 7NK1; 7NK2; 7NK4; 7NK6; 7NK8; 7NKA; 7NKC; 7NKI; 7NKR; 8R60; 8R65

HEMA_I18A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

1RD8; 1RUZ; 2WRG; 3GBN; 3LZF; 3R2X; 4EEF; 4GXU; 4GXX; 4JUG; 4JUH; 4JUJ; 4PY8; 5VMG; 5VMJ

PB1F2_I18A0 Protein PB1-F2

PAX_I18A0 Protein PA-X

PB2_I18A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

7NHA; 7NHC; 7NHX; 7NI0; 7NIK; 7NIL; 7NIR; 7NIS; 7NJ3; 7NJ4; 7NJ5; 7NJ7; 7NK1; 7NK2; 7NK4; 7NK6; 7NK8; 7NKA; 7NKC; 7NKI; 7NKR; 8R60; 8R65

NCAP_I18A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I18A0 Matrix protein 1 (M1)

NS1_I18A0 Non-structural protein 1 (NS1) (NS1A)

2N74; 5UL6; 6ATV; 6DGK; 6NU0; 6OX7; 6U28

PB2S1_I18A0 PB2-S1

NEP_I18A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

13 entries

PB2_I33A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

RDRP_I33A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

HEMA_I33A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I33A0 Neuraminidase (EC 3.2.1.18)

M1_I33A0 Matrix protein 1 (M1)

4PUS; 5V6G; 5V7B; 5V7S; 5V8A; 6I3H; 6QZD

M2_I33A0 Matrix protein 2 (Proton channel protein M2)

PA_I33A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

4IUJ; 5IEQ; 5IF2; 5IF5; 5IF7; 5IF8; 5IFB; 5IFC; 5IFD; 5V0U; 6CFP

PAX_I33A0 Protein PA-X

NCAP_I33A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

3ZDP; 4BBL; 4IRY; 5B7B; 6I7B; 6I85; 6J1U; 9GAQ

NS1_I33A0 Non-structural protein 1 (NS1) (NS1A)

PB1F2_I33A0 Protein PB1-F2

PB2S1_I33A0 PB2-S1

NEP_I33A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/Brazil/11/1978 H1N1)

12 entries

M2_I77AA Matrix protein 2 (Proton channel protein M2)

HEMA_I77AA Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I77AA Neuraminidase (EC 3.2.1.18)

M1_I77AA Matrix protein 1 (M1)

NS1_I77AA Non-structural protein 1 (NS1) (NS1A)

PA_I77AA Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

RDRP_I77AA RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB2_I77AA Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NCAP_I77AA Nucleoprotein (Nucleocapsid protein) (Protein N)

NEP_I77AA Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PB1F2_I77AA Protein PB1-F2

PAX_I77AA Protein PA-X

Influenza A virus (strain A/Chile/1/1983 H1N1)

12 entries

M2_I83A1 Matrix protein 2 (Proton channel protein M2)

HEMA_I83A1 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I83A1 Neuraminidase (EC 3.2.1.18)

M1_I83A1 Matrix protein 1 (M1)

NCAP_I83A1 Nucleoprotein (Nucleocapsid protein) (Protein N)

PA_I83A1 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

RDRP_I83A1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB2_I83A1 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NS1_I83A1 Non-structural protein 1 (NS1) (NS1A)

PB1F2_I83A1 Protein PB1-F2

PAX_I83A1 Protein PA-X

NEP_I83A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

12 entries

NRAM_I96A3 Neuraminidase (EC 3.2.1.18)

M2_I96A3 Matrix protein 2 (Proton channel protein M2)

HEMA_I96A3 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

PB2_I96A3 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

RDRP_I96A3 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PA_I96A3 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

NS1_I96A3 Non-structural protein 1 (NS1) (NS1A)

NCAP_I96A3 Nucleoprotein (Nucleocapsid protein) (Protein N)

4NQX

M1_I96A3 Matrix protein 1 (M1)

PAX_I96A3 Protein PA-X

PB1F2_I96A3 Protein PB1-F2

NEP_I96A3 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/Henry/1936 H1N1)

12 entries

M2_I36A0 Matrix protein 2 (Proton channel protein M2)

HEMA_I36A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I36A0 Neuraminidase (EC 3.2.1.18)

M1_I36A0 Matrix protein 1 (M1)

NCAP_I36A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I36A0 Non-structural protein 1 (NS1) (NS1A)

PA_I36A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

RDRP_I36A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB1F2_I36A0 Protein PB1-F2

PB2_I36A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I36A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PAX_I36A0 Protein PA-X

Influenza A virus (strain A/Hickox/1940 H1N1)

12 entries

M2_I40A0 Matrix protein 2 (Proton channel protein M2)

5JOO; 5TTC; 5UM1

RDRP_I40A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

NRAM_I40A0 Neuraminidase (EC 3.2.1.18)

HEMA_I40A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

6ONA

PAX_I40A0 Protein PA-X

NCAP_I40A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

PB2_I40A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

PB1F2_I40A0 Protein PB1-F2

PA_I40A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

NS1_I40A0 Non-structural protein 1 (NS1) (NS1A)

M1_I40A0 Matrix protein 1 (M1)

NEP_I40A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/India/6263/1980 H1N1)

12 entries

M2_I80AA Matrix protein 2 (Proton channel protein M2)

HEMA_I80AA Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I80AA Neuraminidase (EC 3.2.1.18)

M1_I80AA Matrix protein 1 (M1)

NCAP_I80AA Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I80AA Non-structural protein 1 (NS1) (NS1A)

PA_I80AA Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

RDRP_I80AA RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB2_I80AA Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I80AA Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PB1F2_I80AA Protein PB1-F2

PAX_I80AA Protein PA-X

Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

12 entries

M2_I54A2 Matrix protein 2 (Proton channel protein M2)

8BDZ; 8BER

HEMA_I54A2 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I54A2 Neuraminidase (EC 3.2.1.18)

M1_I54A2 Matrix protein 1 (M1)

NCAP_I54A2 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I54A2 Non-structural protein 1 (NS1) (NS1A)

PA_I54A2 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

RDRP_I54A2 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB2_I54A2 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I54A2 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PB1F2_I54A2 Protein PB1-F2

PAX_I54A2 Protein PA-X

Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

12 entries

M2_I06A0 Matrix protein 2 (Proton channel protein M2)

HEMA_I06A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I06A0 Neuraminidase (EC 3.2.1.18)

RDRP_I06A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

M1_I06A0 Matrix protein 1 (M1)

NCAP_I06A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I06A0 Non-structural protein 1 (NS1) (NS1A)

PA_I06A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PB1F2_I06A0 Protein PB1-F2

PB2_I06A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I06A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PAX_I06A0 Protein PA-X

Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

12 entries

NRAM_I61A1 Neuraminidase (EC 3.2.1.18)

RDRP_I61A1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

M2_I61A1 Matrix protein 2 (Proton channel protein M2)

HEMA_I61A1 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

PA_I61A1 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PB2_I61A1 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NS1_I61A1 Non-structural protein 1 (NS1) (NS1A)

NCAP_I61A1 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I61A1 Matrix protein 1 (M1)

NEP_I61A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PAX_I61A1 Protein PA-X

PB1F2_I61A1 Protein PB1-F2

Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

12 entries

M2_I51A0 Matrix protein 2 (Proton channel protein M2)

HEMA_I51A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I51A0 Neuraminidase (EC 3.2.1.18)

M1_I51A0 Matrix protein 1 (M1)

NCAP_I51A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I51A0 Non-structural protein 1 (NS1) (NS1A)

PA_I51A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

RDRP_I51A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB2_I51A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I51A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PB1F2_I51A0 Protein PB1-F2

PAX_I51A0 Protein PA-X

Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

12 entries

M2_I45A0 Matrix protein 2 (Proton channel protein M2)

HEMA_I45A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I45A0 Neuraminidase (EC 3.2.1.18)

RDRP_I45A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

M1_I45A0 Matrix protein 1 (M1)

NCAP_I45A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I45A0 Non-structural protein 1 (NS1) (NS1A)

PA_I45A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PB1F2_I45A0 Protein PB1-F2

PB2_I45A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

PAX_I45A0 Protein PA-X

NEP_I45A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/USA:Iowa/1943 H1N1)

12 entries

M2_I43A0 Matrix protein 2 (Proton channel protein M2)

HEMA_I43A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I43A0 Neuraminidase (EC 3.2.1.18)

RDRP_I43A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

M1_I43A0 Matrix protein 1 (M1)

NCAP_I43A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I43A0 Non-structural protein 1 (NS1) (NS1A)

PA_I43A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PB1F2_I43A0 Protein PB1-F2

PB2_I43A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

PAX_I43A0 Protein PA-X

NEP_I43A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

12 entries

M2_I96A2 Matrix protein 2 (Proton channel protein M2)

HEMA_I96A2 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I96A2 Neuraminidase (EC 3.2.1.18)

PA_I96A2 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

M1_I96A2 Matrix protein 1 (M1)

NCAP_I96A2 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I96A2 Non-structural protein 1 (NS1) (NS1A)

RDRP_I96A2 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB2_I96A2 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I96A2 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PB1F2_I96A2 Protein PB1-F2

PAX_I96A2 Protein PA-X

Influenza A virus (strain A/USA:Phila/1935 H1N1)

12 entries

M2_I35A3 Matrix protein 2 (Proton channel protein M2)

HEMA_I35A3 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I35A3 Neuraminidase (EC 3.2.1.18)

RDRP_I35A3 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

M1_I35A3 Matrix protein 1 (M1)

NCAP_I35A3 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I35A3 Non-structural protein 1 (NS1) (NS1A)

PA_I35A3 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PB1F2_I35A3 Protein PB1-F2

PB2_I35A3 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I35A3 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PAX_I35A3 Protein PA-X

Influenza A virus (strain A/USSR/90/1977 H1N1)

12 entries

M2_I77AB Matrix protein 2 (Proton channel protein M2)

1NYJ; 2H95

HEMA_I77AB Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I77AB Neuraminidase (EC 3.2.1.18)

NS1_I77AB Non-structural protein 1 (NS1) (NS1A)

NCAP_I77AB Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I77AB Matrix protein 1 (M1)

PB2_I77AB Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

RDRP_I77AB RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PA_I77AB Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

NEP_I77AB Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PAX_I77AB Protein PA-X

PB1F2_I77AB Protein PB1-F2

Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

11 entries

NRAM_I00A1 Neuraminidase (EC 3.2.1.18)

HEMA_I00A1 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

7MFG; 8D21; 8F38; 8UR5; 8UR7

PB2_I00A1 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

RDRP_I00A1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PA_I00A1 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

NS1_I00A1 Non-structural protein 1 (NS1) (NS1A)

NCAP_I00A1 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I00A1 Matrix protein 1 (M1)

PAX_I00A1 Protein PA-X

PB1F2_I00A1 Protein PB1-F2

NEP_I00A1 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)

11 entries

HEMA_I67A2 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

M2_I67A2 Matrix protein 2 (Proton channel protein M2)

NRAM_I67A2 Neuraminidase (EC 3.2.1.18)

RDRP_I67A2 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

M1_I67A2 Matrix protein 1 (M1)

PA_I67A2 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PB2_I67A2 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NCAP_I67A2 Nucleoprotein (Nucleocapsid protein) (Protein N)

NEP_I67A2 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PAX_I67A2 Protein PA-X

PB1F2_I67A2 Putative protein PB1-F2

Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

10 entries

HEMA_I07A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I07A0 Neuraminidase (EC 3.2.1.18)

NCAP_I07A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I07A0 Non-structural protein 1 (NS1) (NS1A)

PA_I07A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

RDRP_I07A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PB2_I07A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

NEP_I07A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PB1F2_I07A0 Protein PB1-F2

PAX_I07A0 Protein PA-X

Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)

8 entries

NRAM_I47A0 Neuraminidase (EC 3.2.1.18)

RDRP_I47A0 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

NS1_I47A0 Non-structural protein 1 (NS1) (NS1A)

NEP_I47A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

PAX_I47A0 Protein PA-X

NCAP_I47A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

PA_I47A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PB2_I47A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)

8 entries

M2_I30A0 Matrix protein 2 (Proton channel protein M2)

PA_I30A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

1YN6; 1YN7; 3PQY

HEMA_I30A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

1RUY

M1_I30A0 Matrix protein 1 (M1)

NCAP_I30A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NS1_I30A0 Non-structural protein 1 (NS1) (NS1A)

PB2_I30A0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

PAX_I30A0 Protein PA-X

Influenza A virus (strain A/Fort Warren/1/1950 H1N1)

5 entries

M2_I50A0 Matrix protein 2 (Proton channel protein M2)

NCAP_I50A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I50A0 Matrix protein 1 (M1)

NS1_I50A0 Non-structural protein 1 (NS1) (NS1A)

NEP_I50A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/Kiev/59/1979 H1N1)

5 entries

HEMA_I79A4 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

1RUY

RDRP_I79A4 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

NRAM_I79A4 Neuraminidase (EC 3.2.1.18)

NCAP_I79A4 Nucleoprotein (Nucleocapsid protein) (Protein N)

PB2_I79A4 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Influenza A virus (strain A/Leningrad/1/1954 H1N1)

5 entries

HEMA_I54A0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NRAM_I54A0 Neuraminidase (EC 3.2.1.18)

NS1_I54A0 Non-structural protein 1 (NS1) (NS1A)

NCAP_I54A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

NEP_I54A0 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

Influenza A virus (strain A/Swine/Netherlands/12/1985 H1N1)

4 entries

M2_I85A4 Matrix protein 2 (Proton channel protein M2)

HEMA_I85A4 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]

NCAP_I85A4 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I85A4 Matrix protein 1 (M1)

Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)

4 entries

M2_I81A4 Matrix protein 2 (Proton channel protein M2)

RDRP_I81A4 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

NCAP_I81A4 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I81A4 Matrix protein 1 (M1)

Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)

4 entries

M2_I77AC Matrix protein 2 (Proton channel protein M2)

NCAP_I77AC Nucleoprotein (Nucleocapsid protein) (Protein N)

PB2_I77AC Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

M1_I77AC Matrix protein 1 (M1)

Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)

4 entries

M2_I88A7 Matrix protein 2 (Proton channel protein M2)

RDRP_I88A7 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

NCAP_I88A7 Nucleoprotein (Nucleocapsid protein) (Protein N)

4MJ5

M1_I88A7 Matrix protein 1 (M1)

Influenza A virus (strain A/Swine/29/1937 H1N1)

3 entries

M2_I37A0 Matrix protein 2 (Proton channel protein M2)

NCAP_I37A0 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I37A0 Matrix protein 1 (M1)

Influenza A virus (strain A/Swine/Iowa/17672/1988 H1N1)

3 entries

M2_I88A5 Matrix protein 2 (Proton channel protein M2)

NCAP_I88A5 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I88A5 Matrix protein 1 (M1)

Influenza A virus (strain A/Swine/May/1954 H1N1)

3 entries

M2_I54A1 Matrix protein 2 (Proton channel protein M2)

NCAP_I54A1 Nucleoprotein (Nucleocapsid protein) (Protein N)

M1_I54A1 Matrix protein 1 (M1)

Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)

3 entries

RDRP_I77AD RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

PA_I77AD Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

PAX_I77AD Protein PA-X

Influenza A virus (strain A/Duck/Australia/749/1980 H1N1)

2 entries

Influenza A virus (strain A/New Jersey/8/1976 H1N1)

2 entries

Influenza A virus (strain A/Swine/New Jersey/11/1976 H1N1)

2 entries

Influenza A virus (strain A/Turkey/Bethlehem-Glilit/1492-B/1982 H1N1)

2 entries

Influenza A virus (strain A/Turkey/Minnesota/1661/1981 H1N1)

2 entries

Influenza A virus (strain swl A/California/04/2009 H1N1)

2 entries

PA_I09A0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

4AVG; 4AVL; 4AVQ; 4AWF; 4AWG; 4AWH; 4AWK; 4AWM; 5CCY; 5CGV; 5CL0; 5CZN; 5D2O; 5D42; 5D4G; 5D8U; 5D9J; 5DBS; 5DEB; 5DES; 5EGA; 5VP8; 5VPT; 5VPX; 5VQN; 5VRJ; 5W3I; 5W44; 5W73; 5W7U; 5W92; 5W9G; 5WA6; 5WA7; 5WAP; 5WB3; 5WCS; 5WCT; 5WDC; 5WDN; 5WDW; 5WE7; 5WE9; 5WEB; 5WEF; 5WEI; 5WF3; 5WFM; 5WFW; 5WFZ; 5WG9; 6DCY; 6DCZ; 6DZQ; 6E0Q; 6E3M; 6E3N; 6E3O; 6E3P; 6E4C; 6E6V; 6E6W; 6E6X; 6FS6; 6FS7; 7K0W; 7LM4; 7ML8; 7MPF; 7MTY; 7MX0; 7MY5; 7N47; 7N55; 7N68; 7N8F; 7RKP; 7V04; 8CTF; 8DAL; 8DDB; 8DDE; 8DHN; 8DJV; 8DJY; 8T5V; 8T5W; 8T5Z; 8T67; 8T6Z; 8T81; 8T94; 8VGZ

PAX_I09A0 Protein PA-X (EC 3.1.-.-)

Influenza A virus (strain A/Beijing/11/1956 H1N1)

1 entry

Influenza A virus (strain A/California/10/1978 H1N1)

1 entry

Influenza A virus (strain A/Duck/Alberta/35/1976 H1N1)

1 entry

Influenza A virus (strain A/Duck/Bavaria/2/1977 H1N1)

1 entry

Influenza A virus (strain A/England/19/1955 H1N1)

1 entry

Influenza A virus (strain A/Ohio/4/1983 H1N1)

1 entry

Influenza A virus (strain A/Swine/41/1949 H1N1)

1 entry

Influenza A virus (strain A/Swine/Cambridge/1/1935 H1N1)

1 entry

Influenza A virus (strain A/Swine/Indiana/1726/1988 H1N1)

1 entry

Influenza A virus (strain A/Swine/Iowa/1946 H1N1)

1 entry

Influenza A virus (strain A/Swine/Iowa/1976/1931 H1N1)

1 entry

Influenza A virus (strain A/Swine/Italy/141/1981 H1N1)

1 entry

Influenza A virus (strain A/Swine/Italy/2/1979 H1N1)

1 entry

Influenza A virus (strain A/Swine/Italy/437/1976 H1N1)

1 entry

Influenza A virus (strain A/Swine/Italy/839/1989 H1N1)

1 entry

Influenza A virus (strain A/Swine/Jamesburg/1942 H1N1)

1 entry

Influenza A virus (strain A/Swine/Ohio/23/1935 H1N1)

1 entry

Influenza A virus (strain A/Swine/Wisconsin/1/1957 H1N1)

1 entry