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Circoviridae (taxid:39724)

VIRION

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Non-enveloped, round, , about 20 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.
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GENOME

Monopartite, circular, of about 1.8 to 3.8 kb.
The genome is replicated through double-stranded intermediates. The replication (Rep) protein initiates .

GENE EXPRESSION

One or two mRNAs encode for the Rep, capsid, and possibly others proteins. Some mRNA can undergo .

ENZYMES

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome .
  3. Viral ssDNA is converted into dsDNA with the participation of cellular factors. gives rise to viral mRNAs.
  4. Viral mRNAs are translated to produce viral proteins.
  5. Replication may be mediated by a Rep protein, and would occur by producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by .
DB LINKS image image

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TAXONOMY Group II: ssDNA viruses
Realm:
Kingdom: Shotokuvirae
Phylum: Cressdnaviricota
Class: Arfiviricetes
Order: Cirlivirales
Family: Circoviridae
Genus:
VIRUS
Human associated cyclovirus 8
 Porcine circovirus 1
 Barbel circovirus
 Bat associated circovirus 1
 Bat associated circovirus 2
 Bat associated circovirus 3
 Bat associated circovirus 4
 Bat associated circovirus 5
 Bat associated circovirus 6
 Bat associated circovirus 7
 Bat associated circovirus 8
 Bat associated circovirus 9
 Bat associated cyclovirus 1
 Bat associated cyclovirus 10
 Bat associated cyclovirus 11
 Bat associated cyclovirus 12
 Bat associated cyclovirus 13
 Bat associated cyclovirus 14
 Bat associated cyclovirus 15
 Bat associated cyclovirus 16
 Bat associated cyclovirus 2
 Bat associated cyclovirus 3
 Bat associated cyclovirus 4
 Bat associated cyclovirus 5
 Bat associated cyclovirus 6
 Bat associated cyclovirus 7
 Bat associated cyclovirus 8
 Bat associated cyclovirus 9
 Beak and feather disease virus
 Bovine associated cyclovirus 1
 Canary circovirus
 Canine circovirus
 Chicken associated cyclovirus 1
 Chimpanzee associated circovirus 1
 Chimpanzee associated cyclovirus 1
 Cockroach associated cyclovirus 1
 Dragonfly associated cyclovirus 1
 Dragonfly associated cyclovirus 2
 Dragonfly associated cyclovirus 3
 Dragonfly associated cyclovirus 4
 Dragonfly associated cyclovirus 5
 Dragonfly associated cyclovirus 6
 Dragonfly associated cyclovirus 7
 Dragonfly associated cyclovirus 8
 Duck circovirus
 European catfish circovirus
 Feline associated cyclovirus 1
 Finch circovirus
 Goat associated cyclovirus 1
 Goose circovirus
 Gull circovirus
 Horse associated cyclovirus 1
 Human associated circovirus 1
 Human associated cyclovirus 1
 Human associated cyclovirus 10
 Human associated cyclovirus 11
 Human associated cyclovirus 12
 Human associated cyclovirus 2
 Human associated cyclovirus 3
 Human associated cyclovirus 4
 Human associated cyclovirus 5
 Human associated cyclovirus 6
 Human associated cyclovirus 7
 Human associated cyclovirus 9
 Mink circovirus
 Mouse associated cyclovirus 1
 Pigeon circovirus
 Porcine circovirus 2
 Porcine circovirus 3
 Raven circovirus
 Squirrel associated cyclovirus 1
 Starling circovirus
 Swan circovirus
 Zebra finch circovirus
REFERENCE STRAINS Porcine circovirus 1
Sequence | Genome assembly | Proteome
Human cyclovirus 1
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS Birds and mammals.
TROPISM CAV: Chicken: Thymocytes, erythrobalstoid cells
Egg: embryonal tissues and eggshell membranes
INTERACTIONS Cell receptors:-
Host-virus interaction

Ecology and disease

GEOGRAPHY Worldwide.
ASSOCIATED DISEASES PCV-2:
CAV: Chicken infectious anemia
TRANSMISSION Porcine circovirus: fecal-oral route
Chicken anemia virus: fecal-oral route
VACCINE PCV-2: Circumvent ® PCV (Intervet / S-P) and Ingelvac CircoFLEX ® (Boehringer Ingelheim).
Chicken anemia virus
ANTIVIRAL DRUGS

Host-virus interaction

Autophagy modulation

Cap protein of PCV2 induces in order to enhance its own replication .

Apoptosis modulation

PCV2 ORF3-encoded protein induces by . This protein may be a candidate for which is essential for nuclear virus replication in mammals.

GENERAL Back to circoviridae page
NATURAL HOSTS Birds and mammals.
TROPISM CAV: Chicken: Thymocytes, erythrobalstoid cells
Egg: embryonal tissues and eggshell membranes
INTERACTIONS Cell receptors:-
ASSOCIATED DISEASES PCV-2:
CAV: Chicken infectious anemia
TRANSMISSION Porcine circovirus: fecal-oral route
Chicken anemia virus: fecal-oral route
...

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

27 entries grouped by strain

Beak and feather disease virus (BFDV) reference strain

7 entries

Select_allDeselect_all
REP_BFDV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_BFDV Capsid protein
ORF4_BFDV Uncharacterized protein ORF4
ORF7_BFDV Uncharacterized protein ORF7
ORF6_BFDV Uncharacterized protein ORF6
ORF5_BFDV Uncharacterized protein ORF5
ORF3_BFDV Uncharacterized protein ORF3

Porcine circovirus 2 (PCV2) reference strain

3 entries

Select_allDeselect_all
CAPSD_PCV2 Capsid protein
REP_PCV2 Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...

pdb 2HW0; 6WDZ; 8H56; 8XMS

NS0_PCV2 Protein NS0

Goose circovirus (GoCV) reference strain

4 entries

Select_allDeselect_all
REP_GOCV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_GOCV Probable capsid protein
ORFC2_GOCV Uncharacterized protein ORFC2
ORFV2_GOCV Uncharacterized protein ORFV2

Canary circovirus (CaCV) reference strain

2 entries

Select_allDeselect_all
REP_CACV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_CACV Probable capsid protein

Human associated cyclovirus 1 (isolate Homo sapiens/Pakistan/PK5510/2007) (HuCyV-1) (Cyclovirus PK5510) reference strain

2 entries

Select_allDeselect_all
REP_HCYV5 Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase ...
CAPSD_HCYV5 Capsid protein

Porcine circovirus 1 (PCV1) reference strain

2 entries

Select_allDeselect_all
REP_PCV1 Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase ...
CAPSD_PCV1 Capsid protein

Pigeon circovirus (PiCV) (Columbid circovirus)

5 entries

Select_allDeselect_all
REP_PICV Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) ...
CAPSD_PICV Probable capsid protein
ORFC3_PICV Uncharacterized protein ORFC3
ORFC4_PICV Uncharacterized protein ORFC4
ORFC2_PICV Uncharacterized protein ORFC2

Porcine circovirus 2 (PCV2)

2 entries

Select_allDeselect_all
ORF3_PCV2 Protein ORF3
ORF4_PCV2 Anti-apoptotic ORF4 protein
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Acartia tonsa copepod circovirus taxid:1168547

Aiptasia sp. sea anemone associated circular virus taxid:1692242

Anguilla anguilla circovirus taxid:1420600

Artemia melana sponge associated circular genome taxid:1692243

Avon-Heathcote Estuary associated circular virus 1 taxid:1618232

Avon-Heathcote Estuary associated circular virus 11 taxid:1618234

Avon-Heathcote Estuary associated circular virus 12 taxid:1618235

Avon-Heathcote Estuary associated circular virus 14 taxid:1618237

Avon-Heathcote Estuary associated circular virus 15 taxid:1618238

Avon-Heathcote Estuary associated circular virus 17 taxid:1618240

Avon-Heathcote Estuary associated circular virus 19 taxid:1618242

Avon-Heathcote Estuary associated circular virus 20 taxid:1618244

Avon-Heathcote Estuary associated circular virus 21 taxid:1618245

Avon-Heathcote Estuary associated circular virus 22 taxid:1618246

Avon-Heathcote Estuary associated circular virus 23 taxid:1618247

Avon-Heathcote Estuary associated circular virus 26 taxid:1618250

Avon-Heathcote Estuary associated circular virus 27 taxid:1618251

Avon-Heathcote Estuary associated circular virus 28 taxid:1618252

Avon-Heathcote Estuary associated circular virus 29 taxid:1618253

Avon-Heathcote Estuary associated circular virus 5 taxid:1618256

Avon-Heathcote Estuary associated circular virus 6 taxid:1618257

Avon-Heathcote Estuary associated circular virus 7 taxid:1618258

Avon-Heathcote Estuary associated circular virus 8 taxid:1618259

Barbel circovirus taxid:759938

Bat circovirus POA/2012/VI taxid:1572239

Calanoida sp. copepod associated circular virus taxid:1692244

Callinectes ornatus blue crab associated circular virus taxid:1692245

Callinectes sapidus associated circular virus taxid:1692246

Canary circovirus taxid:142661

Canine circovirus taxid:1194757

Chimpanzee faeces associated circular DNA virus 1 taxid:1676184

Cyclovirus NGchicken15/NGA/2009 taxid:942037

Cyclovirus PKgoat11/PAK/2009 taxid:942034

Cyclovirus PKgoat21/PAK/2009 taxid:942033

Cyclovirus TsCyV-1_JP-NUBS-2014 taxid:1592764

Cyclovirus ZM36a taxid:1506568

Cyclovirus bat/USA/2009 taxid:942035

Didemnum sp. Sea Squirt associated virus taxid:1692247

Dragonfly associated cyclovirus 1 taxid:1234879

Dragonfly associated cyclovirus 3 taxid:1234881

Dragonfly associated cyclovirus 5 taxid:1234883

Dragonfly cyclovirus 2 taxid:1234880

Duck circovirus taxid:324685

Farfantepenaeus duorarum pink shrimp associated circular virus taxid:1692248

Feline cyclovirus taxid:1530454

Fiddler Crab associated circular virus taxid:1692249

Finch circovirus taxid:400122

Fur seal faeces associated circular DNA virus taxid:1353241

Gammarus sp. amphipod associated circular virus taxid:1692250

Goose circovirus taxid:146032

Gull circovirus taxid:400121

Hermit crab associated circular genome taxid:1692251

Hermit crab associated circular virus taxid:1692252

Human cyclovirus taxid:1455626

Human cyclovirus VS5700009 taxid:1345637

Indian encephalitis associated cyclovirus taxid:1755290

Labidocera aestiva circovirus taxid:1173709

Littorina sp. associated circular virus taxid:1692253

Lytechinus variegatus variable sea urchin associated circular virus taxid:1692254

Marine snail associated circular virus taxid:1692255

Mink circovirus taxid:1475143

Mosquito circovirus taxid:1611039

Mytilus sp. clam associated circular virus taxid:1692256

Palaemonetes intermedius brackish grass shrimp associated circular virus taxid:1692257

Palaemonetes kadiakensis Mississippi grass shrimp associated circular virus taxid:1692258

Palaemonetes sp. common grass shrimp associated circular virus taxid:1692259

Paramuricea placomus associated circular virus taxid:1692260

Penaeus monodon circovirus VN11 taxid:1419711

Petrochirus diogenes giant hermit crab associated circular virus taxid:1692261

Pigeon circovirus taxid:126070

Po-Circo-like virus 21 taxid:1105383

Porcine circovirus 3 taxid:1868221

Porcine circovirus type 1/2a taxid:720569

Porcine stool-associated circular virus 4 taxid:1475062

Porcine stool-associated circular virus 5 taxid:1475063

Primnoa pacifica coral associated circular virus taxid:1692262

Raven circovirus taxid:345250

Sicyonia brevirostris associated circular virus taxid:1692263

Starling circovirus taxid:349370

Swan circovirus taxid:459957

Zebra finch circovirus taxid:1642515