Sedoreoviridae (taxid:2946186)
VIRION

Non enveloped, icosahedral virion with a double capsid structure (except for cypoviruses and dinovernaviruses which have only the equivalent of the inner capsid). The outer capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.
GENOME
Segmented linear dsRNA genome. Contains 10 to 12 segments coding for 10 to 14 proteins. Segments size range from 0.2 to 3.0 kb. Genome total size range from 18.2 to 30.5 kb.
GENE EXPRESSION
The dsRNA genome is never completely uncoated to prevent activation of antiviral state by the cell in response to dsRNA. Viral polymerase synthesizes mRNA from each of the dsRNA segments. These mRNAs are translocated to the cell cytoplasm where they are translated.
Further proteins are produced by leaky scanning and protein processing.
ENZYMES
REPLICATION
CYTOPLASMIC
- Attachement to host receptors probably mediates endocytosis of virus into host cell.
- Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
- Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
- Transcription from each of the dsRNA segments produces mRNA templates for translation.
- Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
- (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
- The capsid is assembled on the sub-viral particle.
- Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.
Host-virus interaction
Apoptosis modulation
Bluetongue virus mediates host cell apoptosis via caspases activaton (caspases-8, caspases-9, caspase-3, and caspase-7) .
Innate immune response inhibition
Rotaviruses counteract many antiviral pathways in a strain-specific manner
:
NSP1 protein induces the proteasome-dependent degradation of IRF3, IRF5, and IRF7 to prevent their induction of IFN
.
NSP1 can also induce proteasome-dependent degradation of the ubiquitin ligase complex protein beta-TrCP, resulting in stabilization of IκB and repress NF-κB
.
.
Rotavirus can prevent STAT1 and STAT2 nuclear translocation
.
BTV NS4 might also be responsible for counteracting the antiviral response of the host
.
Host gene expression shutoff by virus
Rotavirus NSP3 protein evicts cytoplasmic poly(A) binding protein (PABP) from translation initiation complexes and thus "shuts off the translation of cellular polyadenylated mRNAs"":/by_protein/1579.
Inhibition of host poly(A)-binding protein by virus -> Host translation shutoff
.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)663 entries grouped by strain
Rice dwarf virus (isolate Fujian) (RDV) reference strain
13 entries
Banna virus (BAV) reference strain
12 entries
Rice gall dwarf virus (RGDV) reference strain
12 entries
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain
12 entries
Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A) reference strain
12 entries
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both)) reference strain
12 entries
Bluetongue virus 10 (isolate USA) (BTV 10) reference strain
10 entries
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain
11 entries
Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain
11 entries
Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19)) reference strain
11 entries
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
12 entries
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
12 entries
Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)
12 entries
Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
12 entries
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
12 entries
Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))
12 entries
Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
12 entries
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
12 entries
Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
12 entries
Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
12 entries
Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))
12 entries
Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))
12 entries
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
12 entries
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
12 entries
Bluetongue virus 10 (isolate USA) (BTV 10)
1 entry
Rice dwarf virus (isolate Akita) (RDV)
11 entries
Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)
11 entries
Rotavirus X (isolate RVX/Human/Bangladesh/NADRV-B219/2002/GXP[X]) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219))
11 entries
African horse sickness virus (AHSV) (Orbivirus alphaequi)
10 entries
Rotavirus B (isolate RVB/Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
10 entries
Rotavirus A (strain RVA/Cow/United States/NCDV-Lincoln/1969/G6P6[1]) (RV-A) (Rotavirus A (strain Nebraska calf diarrhea virus))
9 entries
Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
9 entries
Wound tumor virus (WTV)
9 entries
Bluetongue virus 1 (isolate South Africa) (BTV 1)
8 entries
Bluetongue virus 11 (isolate USA) (BTV 11)
8 entries
Bluetongue virus 13 (isolate USA) (BTV 13)
8 entries
Bluetongue virus 17 (isolate USA) (BTV 17)
8 entries
Rotavirus A (strain RVA/Monkey/United States/RRV/1975/G3P5B[3]) (RV-A)
8 entries
Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)
8 entries
Rotavirus B (isolate RVB/Rat/United States/IDIR/1984/G1P[X]) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
8 entries
Bluetongue virus 2 (isolate USA) (BTV 2)
7 entries
Rotavirus A (strain RVA/Human/Japan/S2/1980/G2P1B[4]) (RV-A)
7 entries
Rotavirus A (strain RVA/Human/Japan/YO/1977/G3P1A[8]) (RV-A)
7 entries
Bluetongue virus 1 (isolate Australia) (BTV 1)
6 entries
Rice dwarf virus (isolate O) (RDV)
6 entries
Rotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)
6 entries
Rotavirus C (isolate RVC/Cow/Japan/Shintoku/1991/G2P[3]) (RV-C)
6 entries
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11]) (RV-A)
5 entries
Rotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)
5 entries
Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)
5 entries
Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)
5 entries
Rotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) (Rotavirus A (strain Alabama))
5 entries
African horse sickness virus 6 (AHSV-6)
4 entries
African horse sickness virus 9 (AHSV-9)
4 entries
Broadhaven virus (BRD)
4 entries
Epizootic hemorrhagic disease virus 1 (EHDV-1)
4 entries
Rotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)
4 entries
Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) (Rotavirus A (isolate H-2))
4 entries
Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
4 entries
Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)
4 entries
Rotavirus A (strain RVA/Human/United States/M/1976/G3P[X]) (RV-A)
4 entries
Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)
4 entries
Rotavirus A (strain RVA/Turkey/Ireland/Ty-1/1978/G7P[17]) (RV-A)
4 entries
African horse sickness virus 4 (AHSV-4)
3 entries
Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Cow/Germany/993/1983/G18P[17]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Cow/India/Hg18/2000/G15P[21]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Cow/United States/VMRI/1988/G6P[5]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Equine/Japan/HO-5/1980/G3P[X]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Equine/United States/FI-23/1981/G14P4[12]) (RV-A) (Rotavirus A (strain FI23))
3 entries
Rotavirus A (isolate RVA/Human/Italy/VA70/1975/G4P1A[8]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Human/Sweden/1076/1983/G2P2A[6]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Mouse/United States/Eb/1982/G16P10[16]) (RV-A)
3 entries
Rotavirus A (isolate RVA/Pig/Australia/CRW-8/1987/G3P9[7]) (RV-A)
3 entries
Rotavirus A (strain RVA/Chicken/Ireland/Ch2/1979/G7P[X]) (RV-A) (Rotavirus A (strain Ch-2))
3 entries
Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)
3 entries
Rotavirus A (strain RVA/Equine/United States/FI-14/1980/G3P4[12]) (RV-A) (Rotavirus A (strain FI14))
3 entries
Rotavirus A (strain RVA/Human/Australia/RV-5/1981/G2P1B[4]) (RV-A) (Rotavirus A (strain RV5))
3 entries
Rotavirus A (strain RVA/Human/Indonesia/B37/XXXX/G8P[X]) (RV-A)
3 entries
Rotavirus A (strain RVA/Human/Japan/MO/1982/G3P1A[8]) (RV-A)
3 entries
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
3 entries
Rotavirus A (strain RVA/SA11-Patton/G3P[X]) (RV-A) (Simian Agent 11 (strain Patton))
3 entries
Rotavirus A (strain RVA/SA11-Ramig/G3P[X]) (RV-A) (Simian Agent 11 (strain Ramig))
3 entries
Wound tumor virus (strain NJ) (WTV)
3 entries
African horse sickness virus 3 (AHSV-3)
2 entries
Bluetongue virus 13 (isolate 13B89Z) (BTV 13)
2 entries
Epizootic hemorrhagic disease virus 2 (strain Alberta) (EHDV-2)
2 entries
Rotavirus A (isolate RVA/Cow/Japan/KK3/1983/G10P8[11]) (RV-A)
2 entries
Rotavirus A (isolate RVA/Cow/Thailand/61A/1988/G10P7[5]) (RV-A)
2 entries
Rotavirus A (isolate RVA/Cow/Thailand/A5/1988/G8P6[1]) (RV-A)
2 entries
Rotavirus A (isolate RVA/Dog/United States/Cu-1/1982/G3P5A[3]) (RV-A)
2 entries
Rotavirus A (isolate RVA/Human/Thailand/Mc35/1992/G10P11[14]) (RV-A)
2 entries
Rotavirus A (isolate RVA/Pig/Venezuela/A46/1985/G5P13[13]) (RV-A)
2 entries
Rotavirus A (strain RVA/Human/Australia/RV-4/1977/G1P1A[8]) (RV-A) (Rotavirus A (strain RV4))
2 entries
Rotavirus A (strain RVA/Human/Japan/KUN/1980/G2P1B[4]) (RV-A)
2 entries
Rotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))
2 entries
African horse sickness virus 1 (AHSV-1)
1 entry
African horse sickness virus 2 (AHSV-2)
1 entry
African horse sickness virus 5 (AHSV-5)
1 entry
African horse sickness virus 7 (AHSV-7)
1 entry
African horse sickness virus 8 (AHSV-8)
1 entry
Bluetongue virus 1 (isolate South Africa vaccine) (BTV 1)
1 entry
Bluetongue virus 10 (BTV 10)
1 entry
Bluetongue virus 20 (isolate Australia) (BTV 20)
1 entry
Bluetongue virus 3 (isolate South Africa vaccine) (BTV 3)
1 entry
Epizootic hemorrhagic disease virus 2 (strain Australia) (EHDV-2)
1 entry
Eriocheir sinensis reovirus (isolate China/905) (EsRV)
1 entry
Rice dwarf virus (RDV)
1 entry
Rice dwarf virus (isolate S) (RDV)
1 entry
Rotavirus A (isolate RVA/Cat/Japan/FRV-1/1986/G3P3[9]) (RV-A) (Rotavirus A (isolate FRV1))
1 entry
Rotavirus A (isolate RVA/Cow/Argentina/T449/1992/G1P[X]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Cow/Japan/KN-4/1983/G6P8[11]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/-/RK9/XXXX/GXP[X]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/Australia/A91a/1991/G1P[X]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/Australia/Hu5/1977/G2P[X]) (RV-A) (Rotavirus A (isolate Hu/5))
1 entry
Rotavirus A (isolate RVA/Human/Australia/McN13/1980/G3P2A[6]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/Israel/RO1845/1993/G3P5A[3]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/Japan/IGV-80-3/XXXX/GXP[X]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Pig/Australia/AT/1976/G3P9[7]) (RV-A) (Rotavirus A (isolate AT/76))
1 entry
Rotavirus A (isolate RVA/Pig/Australia/BEN144/1989/G4P2B[6]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Pig/Australia/BMI-1/1989/G4P9[7]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Pig/Australia/TFR-41/1987/G5P9[7]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Sheep/China/lp14/1981/G10P[15]) (RV-A)
1 entry
Rotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/United Kingdom/A28/1987/G10P[X]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/Venezuela/HN126/1983/G2P[X]) (RV-A) (Rotavirus A (strain HN-126))
1 entry
Rotavirus A (strain RVA/Pig/Russia/K/1987) (RV-A)
1 entry
Rotavirus A (strain RVA/SA11-SEM/G3P5B[2]) (RV-A) (Simian Agent 11 (strain SEM))
1 entry
Rotavirus C (isolate RVC/Human/Brazil/Belem/1992) (RV-C)
1 entry
Rotavirus C (isolate RVC/Human/Japan/88-220/1988) (RV-C)
1 entry
Rotavirus C (isolate RVC/Human/United Kingdom/Preston/1992) (RV-C)
1 entry
Banna virus (strain Indonesia/JKT-6423/1980) taxid:649604
Callinectes sapidus reovirus 1 taxid:1811230
Protein | ModelArchive |
RNA-directed RNA polymerase (EC 2.7.7.48) | ma-jd-viral-44575 |
Changuinola virus taxid:40052
Chobar Gorge virus taxid:1679172
Fengkai orbivirus taxid:1692107
Homalodisca vitripennis reovirus taxid:411854
Micromonas pusilla reovirus (isolate Netherlands/2005) taxid:649596
Mobuck virus taxid:1408137
Rotavirus A taxid:28875
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) taxid:450149
Rotavirus B (isolate RVB/Human/China/ADRV/1982) taxid:10942
Rotavirus C taxid:36427
Protein | ModelArchive |
Intermediate capsid protein VP6 | ma-jd-viral-50193 |