Orthohepadnavirus (taxid:10405)

General

Orthohepadnavirus is a genus of dsDNA-RT viruses in the Hepadnaviridae family that infect vertebrates. In humans, Hepatitis B virus can cause Hepatitis, or hepatocellular carcinoma.

VIRION

Enveloped, spherical. Diameter from about 42nm. Icosahedric capsid with a T=4 symmetry.

GENOME

Partially dsDNA circular genome, about 3.2 kb in size. Encodes for 7 proteins.

GENE EXPRESSION

The minichromosome is transcribed by cellular RNA polymerase II under the control of four promoters (the core, pre-S1, pre-S2/S, and X promoters) and two enhancer regions (ENH1 and ENH2). The early transcript encodes HBx, all others are late transcripts. The pre-genomic RNA is alternatively spliced. The unspliced form is exported from the nucleus through a PRE motif possibly by capsid protein. The Polymerase and short S proteins are expressed by leaky scanning from the pg mRNA and the S mRNA respectively.

ENZYMES

Reverse transcriptase
- RNA-dependent DNA polymerase [P]
- DNA-dependent DNA polymerase [P]
- Protein-primed terminal transferase [P]
RNAse H [P]

REPLICATION

NUCLEO-CYTOPLASMIC

Virus attaches to host receptors through major surface antigen and enters the cell by an unknown mechanism.
Relaxed circular DNA (RC-DNA) and capsid are transported via microtubules to the nucleus where DNA is released through the nuclear pore, and repaired to form covalently closed circular DNA (cccDNA).
Transcription by RNA polymerase II of the viral mRNAs and the pregenomic RNA (pgRNA).
The unspliced pregenomic RNA leaves the nucleus by nuclear pore export.
In the cytoplasm pgRNA is encapsidated, together with the P protein, and reverse-transcribed inside the nucleocapsid in new RC-DNA.
Transport to the nucleus of new RC-DNA leads to cccDNA amplification; alternatively, the RC-DNA containing nucleocapsids are enveloped at the ER, and new virions are released by exocytosis.

DB LINKS

HBVdb: The Hepatitis B Virus database

TAXONOMY Group VI: RNA reverse transcribing viruses

Realm:	Riboviria
Kingdom:	Pararnavirae
Phylum:	Artverviricota
Class:	Revtraviricetes
Order:	Blubervirales
Family:	Hepadnaviridae
Genus:	Orthohepadnavirus

ETYMOLOGY Ortho: from Greek "right" or "correct"
hepadnavirus: from hepatitis DNA virus.

VIRUS

Hepatitis B virus
Ground squirrel hepatitis virus
Long-fingered bat hepatitis B virus
Pomona bat hepatitis B virus
Roundleaf bat hepatitis B virus
Tent-making bat hepatitis B virus
Woodchuck hepatitis virus
Woolly monkey hepatitis B virus

REFERENCE STRAIN Hepatitis B virus
Sequence | Genome assembly | Proteome

Host

HOST Human, Mammals

CELL TROPISM Hepatocytes

INTERACTIONS Host-virus interaction
Cell receptors HBV: heparan sulfate

SLC10A1/NTCP

Ecology and disease

GEOGRAPHY Worldwide

ASSOCIATED DISEASES Hepatitis, hepatocellular carcinoma (chronic infections), cirrhosis

TRANSMISSION Sexual contact, blood, maternal-neonatal

VACCINE Subunit vaccine for Human Hepatitis B virus

ANTIVIRAL DRUGS Interferon type I (Cytokine)
Peginterferon alfa2a (Cytokine)
Lamivudine (Nucleoside analog)
Entecavir (Nucleoside analog)
Telbivudine (Nucleoside analog)
Myrcludex B (Experimental, Viral glycoprotein analog)
RG7795 (Experimental, TLR7 agonist)

Host-virus interaction

Primary receptor

HBV L surface protein can bind to heparan sulfate

Entry receptor

HBV L surface protein Binds to SLC10A1/NTCP in order to enter hepatocytes.

Autophagy modulation

HBx seems to be able to increase autophagy through the up-regulation of host beclin 1 expression .

Cell-cycle modulation

HBx protein deregulates cell cycle checkpoint controls at G0/G1 and G2/M .

Innate immune response inhibition

HBx directly interacts with and inhibits host MAVS protein by inducing its ubiquitination and targeting it for degradation .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

264 entries grouped by strain

reorder by protein

Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain

7 entries

HBSAG_HBVD3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVD3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

6HTX; 6HU4; 6HU7; 7OCO; 7OCW; 7OD4; 7OD6; 7OD7; 7OD8; 7OEN; 7OEV; 7OEW; 7PZ9; 7PZI; 7PZK; 7PZL; 7PZM; 7PZN; 8G5V; 8G6V; 8PWO; 8UYT; 8UYU; 8UYV; 8UYW

DPOL_HBVD3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVD3 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVD3 External core antigen (HBeAg) (Precore protein) (p25)

8PX3; 8PX6

Y10K_HBVD3 Putative uncharacterized 10.4 kDa protein

Y15K_HBVD3 Putative uncharacterized 15.3 kDa protein

Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C) reference strain

4 entries

HBEAG_HBVC1 External core antigen (HBeAg) (Precore protein) (p25)

DPOL_HBVC1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVC1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVC1 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain

5 entries

X_HBVCJ Protein X (HBx) (Peptide X) (pX)

CAPSD_HBVCJ Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

5E00; 7ABL

HBSAG_HBVCJ Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

8RQF

HBEAG_HBVCJ External core antigen (HBeAg) (Precore protein) (p25)

DPOL_HBVCJ Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D) reference strain

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D) reference strain

5 entries

HBSAG_HBVD4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVD4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVD4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVD4 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVD4 Truncated HBeAg protein

Woodchuck hepatitis B virus (isolate 8) (WHV) reference strain

5 entries

HBEAG_WHV5 External core antigen (HBeAg) (Precore protein) (p25)

DPOL_WHV5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

HBSAG_WHV5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

7TUL

CAPSD_WHV5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_WHV5 Protein X (HBx) (Peptide X) (pX)

Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)

5 entries

HBSAG_HBVCP Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVCP Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVCP Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

1HHH

X_HBVCP Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVCP Truncated HBeAg protein

Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)

5 entries

HBEAG_HBVGB External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVGB Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVGB Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

HBSAG_HBVGB Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

X_HBVGB Protein X (HBx) (Peptide X) (pX)

Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)

5 entries

HBEAG_HBVGO External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVGO Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

HBSAG_HBVGO Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVGO Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVGO Protein X (HBx) (Peptide X) (pX)

Ground squirrel hepatitis virus (strain 27) (GSHV)

5 entries

HBEAG_GSHV External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_GSHV Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_GSHV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_GSHV Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_GSHV Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)

5 entries

HBSAG_HBVA6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1KC5; 1KCR; 1KCS

HBEAG_HBVA6 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVA6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVA6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVA6 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)

5 entries

HBEAG_HBVA7 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVA7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVA7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVA7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVA7 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)

5 entries

HBSAG_HBVA2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

HBEAG_HBVA2 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVA2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

3J2V; 6UI6; 6UI7

DPOL_HBVA2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVA2 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)

5 entries

HBEAG_HBVA4 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVA4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVA4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVA4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVA4 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)

5 entries

HBSAG_HBVA3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVA3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

HBEAG_HBVA3 External core antigen (HBeAg) (Precore protein) (p25)

DPOL_HBVA3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVA3 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)

5 entries

HBSAG_HBVA9 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

HBEAG_HBVA9 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVA9 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVA9 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVA9 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)

5 entries

HBEAG_HBVA8 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVA8 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

HBSAG_HBVA8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVA8 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVA8 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)

5 entries

HBEAG_HBVB4 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVB4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVB4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVB4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVB4 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)

5 entries

HBSAG_HBVB8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVB8 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVB8 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVB8 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVB8 Truncated HBeAg protein

Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)

5 entries

HBSAG_HBVB7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVB7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVB7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVB7 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVB7 Truncated HBeAg protein

Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)

5 entries

HBEAG_HBVB1 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVB1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVB1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVB1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVB1 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)

5 entries

HBEAG_HBVB2 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVB2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVB2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVB2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVB2 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)

5 entries

HBSAG_HBVB3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVB3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVB3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVB3 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVB3 Truncated HBeAg protein

Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)

5 entries

HBSAG_HBVB6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVB6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVB6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVB6 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVB6 Truncated HBeAg protein

Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)

5 entries

HBEAG_HBVC0 External core antigen (HBeAg) (Precore protein) (p25)

3OX8; 3OXR; 3OXS

HBSAG_HBVC0 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVC0 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVC0 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVC0 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)

1 entry

Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)

5 entries

HBEAG_HBVC3 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVC3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVC3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVC3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVC3 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)

5 entries

HBSAG_HBVC2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

HBEAG_HBVC2 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVC2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVC2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVC2 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)

5 entries

HBSAG_HBVC9 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVC9 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVC9 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVC9 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVC9 Truncated HBeAg protein

Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)

5 entries

HBSAG_HBVC7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

8YMJ; 8YMK

HBEAG_HBVC7 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVC7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVC7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVC7 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)

5 entries

HBSAG_HBVD2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVD2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVD2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVD2 Protein X (HBx) (Peptide X) (pX)

HBEAG_HBVD2 Truncated HBeAg protein

Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)

4 entries

HBEAG_HBVD7 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVD7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVD7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVD7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)

5 entries

HBSAG_HBVD5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVD5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVD5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

HBEAG_HBVD5 External core antigen (HBeAg) (Precore protein) (p25)

X_HBVD5 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)

5 entries

HBEAG_HBVD6 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVD6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

HBSAG_HBVD6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVD6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVD6 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)

5 entries

HBEAG_HBVF1 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVF1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVF1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVF1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVF1 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)

5 entries

HBEAG_HBVF6 External core antigen (HBeAg) (Precore protein) (p25)

HBSAG_HBVF6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVF6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVF6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVF6 Protein X (HBx) (Peptide X) (pX)

8GTX

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)

5 entries

HBSAG_HBVH3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVH3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

HBEAG_HBVH3 External core antigen (HBeAg) (Precore protein) (p25)

DPOL_HBVH3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVH3 Protein X (HBx) (Peptide X) (pX)

Woodchuck hepatitis B virus (isolate 1) (WHV)

5 entries

HBEAG_WHV1 External core antigen (HBeAg) (Precore protein) (p25)

6ECS

HBSAG_WHV1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_WHV1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_WHV1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_WHV1 Protein X (HBx) (Peptide X) (pX)

3I7K

Woodchuck hepatitis B virus (isolate 2) (WHV)

5 entries

HBEAG_WHV2 External core antigen (HBeAg) (Precore protein) (p25)

DPOL_WHV2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

HBSAG_WHV2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_WHV2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_WHV2 Protein X (HBx) (Peptide X) (pX)

Woodchuck hepatitis B virus (isolate 59) (WHV)

5 entries

HBEAG_WHV3 External core antigen (HBeAg) (Precore protein) (p25)

6EDJ

DPOL_WHV3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

HBSAG_WHV3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_WHV3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_WHV3 Protein X (HBx) (Peptide X) (pX)

Woodchuck hepatitis B virus (isolate 7) (WHV)

5 entries

HBEAG_WHV4 External core antigen (HBeAg) (Precore protein) (p25)

DPOL_WHV4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

HBSAG_WHV4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_WHV4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_WHV4 Protein X (HBx) (Peptide X) (pX)

Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

5 entries

HBSAG_WMHBV Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_WMHBV Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_WMHBV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

HBEAG_WMHBV External core antigen (HBeAg) (Precore protein) (p25)

X_WMHBV Protein X (HBx) (Peptide X) (pX)

Arctic squirrel hepatitis virus (ASHV)

4 entries

HBEAG_ASHV External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_ASHV Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_ASHV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_ASHV Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)

4 entries

HBSAG_HBVA5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

HBEAG_HBVA5 External core antigen (HBeAg) (Precore protein) (p25)

CAPSD_HBVA5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVA5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)

4 entries

HBSAG_HBVC5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1WZ4

DPOL_HBVC5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

CAPSD_HBVC5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

X_HBVC5 Protein X (HBx) (Peptide X) (pX)

8WLS

Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)

4 entries

HBSAG_HBVC8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVC8 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVC8 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVC8 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)

4 entries

HBSAG_HBVC4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVC4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVC4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

XCORE_HBVC4 Putative X-Core fused protein

Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)

4 entries

HBSAG_HBVG3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVG3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

DPOL_HBVG3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVG3 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)

3 entries

HBSAG_HBVB5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

8HRX; 8HRY

DPOL_HBVB5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVB5 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)

3 entries

HBSAG_HBVE2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVE2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVE2 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)

3 entries

HBSAG_HBVE4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVE4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVE4 Protein X (HBx) (Peptide X) (pX)

3I7H

Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)

3 entries

HBSAG_HBVE1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVE1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVE1 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)

3 entries

HBSAG_HBVF4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVF4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVF4 Protein X (HBx) (Peptide X) (pX)

5FCG

Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)

3 entries

HBSAG_HBVH1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVH1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVH1 Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)

3 entries

HBSAG_HBVH2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVH2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVH2 Protein X (HBx) (Peptide X) (pX)

Orangutan hepatitis B virus (isolate Somad) (HBVoru)

3 entries

HBSAG_HBVOR Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

DPOL_HBVOR Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

X_HBVOR Protein X (HBx) (Peptide X) (pX)

Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)

2 entries

HBSAG_HBVD1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

CAPSD_HBVD1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

2G33; 2G34; 2QIJ; 3KXS; 4BMG; 4G93; 5D7Y; 5E0I; 5GMZ; 5WTW; 6BVF; 6BVN; 6CWD; 6CWT; 6J10; 6VZP; 6W0K; 6WFS; 7K5M; 7S76; 7UMI; 8GBU; 8I71; 8KHU; 8UYX; 8UYY; 8UYZ; 8W9G

Hepatitis B virus genotype E (isolate Chimpanzee/Ch195/1999) (HBV-E)

2 entries

Hepatitis B virus genotype F1 (isolate Argentina/sa11/2000) (HBV-F)

2 entries

Hepatitis B virus genotype F1 subtype adw4 (isolate El Salvador/1116Sal/1997) (HBV-F)

2 entries

Hepatitis B virus genotype G (isolate United States/USG17/2002) (HBV-G)

2 entries

Hepatitis B virus genotype A1 subtype adw2 (isolate Southern-Africa/Cai) (HBV-A)

1 entry

Hepatitis B virus genotype C subtype adr (isolate China/NC-1/1988) (HBV-C)

1 entry

Hepatitis B virus genotype G subtype adw2 (isolate United States/sf/1990) (HBV-G)

1 entry

Woodchuck hepatitis B virus (isolate w64/pWS23) (WHV)

1 entry

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna

(ModelArchive).

Hepatitis B virus taxid:10407

Protein	ModelArchive
Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)	ma-jd-viral-16242
Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)	ma-jd-viral-16247
HBsAg (Surface antigen) (Major Surface Antigen) (S protein) (Small surface antigen) (Small surface...	ma-jd-viral-48173
Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface...	ma-jd-viral-48176
Middle S protein (Middle surface antigen)	ma-jd-viral-48171
Protein P	ma-jd-viral-49615
Protein X (HBx) (Peptide X) (pX)	ma-jd-viral-29343
Small surface protein	ma-jd-viral-48173
Small surface protein	ma-jd-viral-48173
Small surface protein	ma-jd-viral-48173

Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) taxid:490133

Protein	ModelArchive
Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)	ma-jd-viral-16247

Horseshoe bat hepatitis B virus taxid:1508711

Protein	ModelArchive
External core antigen	ma-jd-viral-16246
Protein P (EC 2.7.7.49) (EC 2.7.7.7)	ma-jd-viral-49622
Protein X (HBx) (Peptide X) (pX)	ma-jd-viral-29346
Surface protein	ma-jd-viral-48177

Roundleaf bat hepatitis B virus taxid:1508710

Protein	ModelArchive
External core antigen	ma-jd-viral-16241
Protein P (EC 2.7.7.49) (EC 2.7.7.7)	ma-jd-viral-49613
Protein X (HBx) (Peptide X) (pX)	ma-jd-viral-29342
Surface protein	ma-jd-viral-48179

Tent-making bat hepatitis B virus taxid:1508712

Protein	ModelArchive
Core protein	ma-jd-viral-16240
Protein P (EC 2.7.7.49) (EC 2.7.7.7)	ma-jd-viral-49618
Protein X (HBx) (Peptide X) (pX)	ma-jd-viral-29348
Surface protein	ma-jd-viral-48178