Species code:	STRPM
Taxonomy:	Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 319700) [NEWT/ NCBI]
Description:	The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. Serotype M28 GAS (Group A Streptococcus) strains are overrepresented among cases of puerperal sepsis and neonatal GAS infections. They also cause diverse types of invasive infections and pharyngitis. Streptococcus pyogenes strain MGAS6180 is a genetically representative strain of the serotype M28. Four regions of the genome contain prophage-like elements or apparent remnants of prophage-like elements. It also contains 2 regions of more than 10 kb with unique and largely nonprophage DNA.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins:0
Statistics:	Number of STRPM entries in the UniProt Knowledgebase: 1884 (300 in UniProtKB/Swiss-Prot + 1584 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number CP000056 (circular; 1,897,573 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] PubMed=16088825; [ NCBI , EBI , Israel , Japan ] Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M. ; "Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity."; J. Infect. Dis. 192:760-770(2005).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Streptococcus&GLspecies=pyogenes&GLstrain=MGAS6180 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid319701%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MGAS6180 NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=319701.3;page=SearchResult PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p13887_Str_pyoge TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntsp13  EBI Proteome Analysis page

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