Species code:	PORGI
Taxonomy:	Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae; Porphyromonas (TaxID: 837) [NEWT/ NCBI]
Description:	Porphyromonas gingivalis is a Gram-negative anaerobe. It is a secondary colonizer of the oral cavity and has a role in the initiation and progression of periodontal disease, which is the major cause of tooth loss in industrial nations. It is a chronic inflammatory disease of the periodontium that leads to erosion of the attachment apparatus and supporting bone for teeth and is one of the most frequently occurring infectious diseases in humans. Recently, a number of epidemiological studies have shown significant relationships between periodontal diseases and cardiovascular diseases. P.gingivalis, which is often found in deep periodontal pockets of humans, is asaccharolytic and highly proteolytic and produces a broad array of potential virulence factors involved in tissue colonization and destruction as well as host defense perturbation. P. gingivalis strains are divided into virulent and less-virulent strans; W83 is a virulent strain, typically inducing a necrotic lesion at the site of injection within 24 h. Animal death is among the other symptoms (adapted from PubMed 18524787).
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of PORGI entries in the UniProt Knowledgebase: 1863 (271 in UniProtKB/Swiss-Prot + 1592 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AE015924 (circular; 2,343,476 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=22829867; PubMed=12949112; [ NCBI , EBI , Israel , Japan ] Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M. ; "Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83."; J. Bacteriol. 185:5591-5601(2003).
Web links:	Official genome site(s): http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=gpg Other web sites: CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Porphyromonas&GLspecies=gingivalis&GLstrain=W83 Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid242619%5Borgn%5D GIB (DDJB): http://gib.genes.nig.ac.jp/single/index.php?spid=Pgin_W83 PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p48_Por_gingi  EBI Proteome Analysis page

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