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HAMAP: Mycobacterium tuberculosis complete proteome

General information

Species:  Mycobacterium tuberculosis
Species code: MYCTU
Taxonomy: Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex (TaxID: 1773) [NEWT/ NCBI]
Description: Acid-fast, obligate aerobic, non-motile, rod-shaped bacterium. It is responsible for tuberculosis. Tuberculosis is, to this day, according to the WHO, the leading killer of adults. This is especially the case in HIV-positive individuals. Drug resistant strains are emerging mainly because people do not complete their treatment plans or have been incorrectly treated and so have remained infectious.
Properties: Presence of flagella: No
Interaction: Animal pathogen in Mammalia
Number of membranes: 1
Number of inteins: 3 in 3 different sequences
Statistics: Number of MYCTU entries in the UniProt Knowledgebase: 3948 (1438 in UniProtKB/Swiss-Prot + 2510 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC 25618 / H37Rv
Genome structure:
Chromosome EMBL accession number AL123456 (circular; 4,411,532 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] MEDLINE=98295987; PubMed=9634230; [ NCBI , EBI , Israel , Japan ]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. ;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
Web links:
Official genome site(s):
http://www.sanger.ac.uk/Projects/M_tuberculosis/
Other web sites:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Mycobacterium&GLspecies=tuberculosis&GLstrain=H37Rv
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=224
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mtub_H37RV
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Mycobacterium_tuberculosis.html
MtbRvCyc: http://biocyc.org/MTBRV/organism-summary?object=MTBRV
PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p224_Myc_tuber
Structural genomics: http://www.doe-mbi.ucla.edu/TB/
TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntmt02
TubercuList: http://genolist.pasteur.fr/TubercuList/
 EBI Proteome Analysis page

Strain:    CDC 1551 / Oshkosh
Genome structure:
Chromosome EMBL accession number AE000516 (circular; 4,403,837 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] MEDLINE=22206494; PubMed=12218036; [ NCBI , EBI , Israel , Japan ]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. ;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Mycobacterium&GLspecies=tuberculosis&GLstrain=CDC1551
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?db=genomeprj&cmd=Retrieve&dopt=Overview&list_uids=223
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mtub_CDC1551
MtbCdcCyc: http://biocyc.org/MTBCDC/organism-summary?object=MTBCDC
PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p223_Myc_tuber
Secreted proteins: http://tbsp.phri.org/
Structural genomics: http://www.doe-mbi.ucla.edu/TB/
TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=gmt
 EBI Proteome Analysis page



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