Search for
You are here: ExPASy CH  > Databases  > Around UniProtKB  > HAMAP

Home Proteomes Families Documents Downloads Links
HAMAP: Mycobacterium bovis (strain BCG / Pasteur 1173P2) complete proteome

General information

Species:  Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Species code: MYCBP
Taxonomy: Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex (TaxID: 410289) [NEWT/ NCBI]
Description: Mycobacterium bovis is a major cause of tuberculosis in a range of animal species and man. It was also the progenitor of the M.bovis bacillus Calmette-Guerin (BCG) strain used as a vaccine against tuberculosis. BCG was derived by serial passages on slices of potato imbibed with glycerol for 13 years. Once the strain was proven to no longer be virulent it was disseminated and different laboratories continued this passaging. This particular strain, M.bovis BCG 1173P2, has been passaged 1,173 times at the Pasteur Institute Paris, France. Different centers have different stocks of BCG, which have continued to change with time, accumulating insertion, deletion and single nucleotide polymorphisms. M.bovis BCG 1173P2 has two independent tandem duplications, DU1 and DU2; DU1 is found only in this Pasteur strain whereas different forms of DU2 are found in different BCG strains. A genealogy of BCG strains is presented in the paper as well as transcriptomic analysis of several different early and late BCG strains. It is suggested that the strains currently used for vaccine production are not optimal and that an earlier derived strain, such as those still used in Japan, might make a better vaccine, a suggestion that the authors recommend should be tested in clinical trials.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: Animal pathogen in Mammalia; Avirulent strain
Number of membranes: 1
Number of inteins: 3 in 3 different sequences
Statistics: Number of MYCBP entries in the UniProt Knowledgebase: 3891 (388 in UniProtKB/Swiss-Prot + 3503 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    BCG / Pasteur 1173P2
Genome structure:
Chromosome EMBL accession number AM408590 (circular; 4,374,522 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] PubMed=17372194; [ NCBI , EBI , Israel , Japan ]
Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P., Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K., Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C., Barrell B.G., Parkhill J., Cole S.T. ;
"Genome plasticity of BCG and impact on vaccine efficacy.";
Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
Web links:
Official genome site(s):
http://www.pasteur.fr/recherche/unites/Lgmb/mycogenomics.html#bovis
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid410289%5Borgn%5D
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=18059
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mbov_BCG_1173P2
GOLD: http://genomesonline.org/GOLD_CARDS/Gc00489.html
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p18059_Myc_bovis
 EBI Proteome Analysis page



Tools