Species code:	CALS8
Taxonomy:	Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor (TaxID: 351627) [NEWT/ NCBI]
Description:	Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903) is a thermophilic (70 degrees Celsius), strictly anaerobic asporogenous bacterium phylogenetically associated with the Firmicutes. This organism was isolated from a thermal spring in New Zealand. It hydrolyses a variety of polymeric carbohydrates (cellulose, hemicellulose, pectin, a -glucan (starch, glycogen), b-glucan (lichenan, laminarin), guar gum) to acetate, lactate, hydrogen and CO2. Trace amounts of ethanol are formed as well. Phylogenetic analysis showed that it constitutes a novel lineage within the Bacillus/Clostridium subphylum of the Gram-positive bacteria. According to a recent study by the US Department of Energy and the National Renewable Energy Laboratory (DOE/NREL), the desired future biofuel producer would have several features that distinguish it from currently used microorganisms: (i) high yield and low product inhibition, (ii) simultaneous utilisation of sugars (cellulose, hemicellulose, pectin), and (iii) growth at elevated temperatures: robust thermophilic organisms, with a decreased risk of contamination. A bacterium that meets all these criteria is Caldicellulosiruptor saccharolyticus, which is anticipated to play an important role in the development of renewable energy. This thermophilic bacterium efficiently converts an extraordinarily wide range of biomass components to the potential energy source hydrogen. Importantly, pilot fermentation experiments revealed the simultaneous degradation of glucose and xylose. Comparison of its genome with that of related microbes, also with potential for energy production, is expected to result in a gain of fundamental insight in the metabolic capacity and its regulation. Follow-up studies will be aimed at exploiting that knowledge for the engineering of an optimised microbial energy production system.
Properties:	Presence of flagella: Yes Interaction: No Number of membranes: 1 Number of inteins:0
Statistics:	Number of CALS8 entries in the UniProt Knowledgebase: 2625 (241 in UniProtKB/Swiss-Prot + 2384 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number CP000679 (circular; 2,970,275 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A., VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J., Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M., Kengen S.M.W., Richardson P. ; "Genome sequence of the thermophilic hydrogen-producing bacterium Caldicellulosiruptor saccharolyticus DSM 8903."; Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid351627%5Borgn%5D Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=13466 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Csac_DSM8903 PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p13466_Cal_sacch  EBI Proteome Analysis page

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