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External resources - (No support from the ExPASy Team)Showing 6 records out of 6 total
Missense3D predicts the structural changes introduced by an amino acid substitution and is applicable to analyse both PDB coordinates and homology-predicted structures.
keywords: disease mutation, protein variation (variant)
PhyreRisk is a dynamic web application developed to enable the exploration and mapping of genetic variants onto experimental and predicted structures of proteins and protein complexes. PhyreRisk integrates data from several public domain and in-house databases with information about diseases, genetic variation, biological pathways and protein structure and then facilitate the informed analysis by a wide community of users throughout the world.
keywords: disease mutation, protein variation (variant)
SwissVar is a portal to search variants (polymorphism) in UniProt Knowledgebase (UniProtKB) entries, and gives direct access to manual annotation on the genotype-phenotype relationship of each specific variant based on literature, as well as pre-computed information (such as conservation scores and a list of structural features when available) to help assess the effect of the variant.
The UniProt Knowledgebase (UniProtKB) is produced by the UniProt consortium and is the central hub for the collection of functional information on proteins with accurate, consistent and rich annotation. It consists of: UniProtKB/Swiss-Prot (manually-annotated records and curator-evaluated computational analysis) and UniProtKB/TrEMBL (computationally analyzed records awaiting manual annotation).
keywords: disease mutation, enzyme (catalytic activity), functional annotation, gene nomenclature, glycosylation, oligosaccharide (glycan, sugar), pathway, physico-chemical property, post-translational modification (PTM), protein data bank (PDB), protein domain, protein family, protein function, protein nomenclature, protein sequence analysis (primary structure), protein variation (variant), proteome database, quaternary structure, sequence alignment, sequence analysis, tertiary structure, transmembrane (trans-membrane)
UniProtKB/Swiss-Prot is the manually annotated component of UniProtKB (produced by the UniProt consortium). It contains manually-annotated (reviewed) records with information extracted from the literature and curator-evaluated computational analysis.
keywords: disease mutation, enzyme (catalytic activity), family database, functional annotation, gene nomenclature, glycosylation, influenza, Pathology (disease), pathway, physico-chemical property, post-translational modification (PTM), protein data bank (PDB), protein domain, protein family, protein function, protein nomenclature, protein sequence analysis (primary structure), protein variation (variant), quaternary structure, secondary structure, sequence alignment, sequence analysis, tertiary structure, topology prediction, transmembrane (trans-membrane)
Computes all possible crosslinks based on proteins of interest (max. 30 proteins) for further interrogation using standard search engine (e.g. Phenyx, Mascot, Sequest, OMSSA, X!Tandem)