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annotation rule: PRU00159


General rule information

Accession PRU00159
Dates 12-DEC-2003 (Created)
7-AUG-2007 (Last updated, Version 26)
Data class Domain
Predictors PROSITE; PS50011; PROTEIN_KINASE_DOM
Names Protein kinase domain
Function Undefined.


Propagated annotation

Description

case <Feature:PS00108>
+ (EC=2.7.11.-)

else case <Feature:PS00109>
+ (EC=2.7.10.-)

else case (<Feature:PS50011:124=D> and <Feature:PS50011:30=K>)
+ (EC=2.7.-.-)
end case

Comments

case not (<Feature:PS50011:30=K> and <Feature:PS50011:124=D>)
DOMAIN: The protein kinase domain is predicted to be catalytically inactive.
end case


case <Feature:PS00108>
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

else case <Feature:PS00109>
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family.
end case

SIMILARITY: Contains # protein kinase domain.
Cross-references

case <Feature:PS50011:30=K>
PROSITE PS00107; PROTEIN_KINASE_ATP; 1;
end case

case <Feature:PS00108>
PROSITE PS00108; PROTEIN_KINASE_ST; 1;
else case <Feature:PS00109>
PROSITE PS00109; PROTEIN_KINASE_TYR; 1;
end case

Gene Ontology

case <Feature:PS00108>
GO:0016301; Molecular function: kinase activity.
GO:0016740; Molecular function: transferase activity.
GO:0004674; Molecular function: protein serine/threonine kinase activity.
Keywords
Kinase, Transferase, Serine/threonine-protein kinase.
Gene Ontology

else case <Feature:PS00109>
GO:0016301; Molecular function: kinase activity.
GO:0016740; Molecular function: transferase activity.
GO:0004713; Molecular function: protein-tyrosine kinase activity.
Keywords
Kinase, Transferase, Tyrosine-protein kinase.
end case

Gene Ontology

case <Feature:PS50011:30=K>
GO:0005524; Molecular function: ATP binding.
GO:0000166; Molecular function: nucleotide binding.
Keywords
ATP-binding, Nucleotide-binding.
end case

Features
From: PS50011
Key     From     To       Description   Condition   FTGroup
DOMAIN     from     to       Protein kinase #      
case <Feature:PS50011:30=K>
Key     From     To       Description   Condition   FTGroup
NP_BIND     7     15       ATP (By similarity)      
BINDING     30     30       ATP (By similarity)      
end case

case <Feature:PS50011:124=D> and <Feature:PS50011:30=K>
Key     From     To       Description   Condition   FTGroup
ACT_SITE     124     124       Proton acceptor (By similarity)      
end case



Additional information

Size range: 205-549 amino acids
Related UniRules: None
Repeats: 1-2
Topology: Undefined
Example: O54967 (ACK1_MOUSE)
Scope: Eukaryota
Bacteria
Viruses
Copyright
PROSITE is copyright. It is produced by the Swiss Institute of Bioinformatics (SIB). There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: http://www.expasy.org/prosite/prosite_license.htm

View rule in raw text format (no links)




UniProtKB rule member sequences



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