HAMAP rule MF_01968
General rule information
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Accession | MF_01968 |
Dates | 2-APR-2012 (Created)
19-NOV-2022 (Last updated, Version 11) |
Name | Sirtuin_ClassU |
Scope(s) |
Bacteria Archaea |
Template(s) | Q9WYW0 (NPD_THEMA); [ Recover all ] |
Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01968 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | NPD |
Protein name | RecName: Full=NAD-dependent protein deacetylase; EC=2.3.1.286; AltName: Full=Regulatory protein SIR2 homolog; |
Gene name | Name=cobB; |
Comments
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case <OC:Archaea> | |
FUNCTION | NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. |
else | |
FUNCTION | NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. |
end case | |
CATALYTIC ACTIVITY | Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; |
case <FTGroup:1> | |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the sirtuin family. Class U subfamily. |
Keywords
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Cytoplasm | |
NAD | |
case <FTGroup:1> | |
Metal-binding | |
Zinc | |
end case | |
case <OC:Archaea> | |
Transcription | |
Transcription regulation | |
end case | |
Transferase |
Gene Ontology
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GO:0005737; Cellular component:cytoplasm | |
GO:0034979; Molecular function:NAD-dependent protein deacetylase activity | |
GO:0070403; Molecular function:NAD+ binding | |
GO:0006476; Biological process:protein deacetylation | |
case <FTGroup:1> | |
GO:0008270; Molecular function:zinc ion binding | |
end case |
Cross-references
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Features
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From: NPD_THEMA (Q9WYW0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 116 | 116 | /note="Proton acceptor" | H | ||||||||
BINDING | 22 | 22 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
A | ||||||||
BINDING | 26 | 26 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
T | ||||||||
BINDING | 33 | 33 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[FY] | ||||||||
BINDING | 33 | 33 | /ligand="nicotinamide" /ligand_id="ChEBI:CHEBI:17154" |
[FY] | ||||||||
BINDING | 34 | 34 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
BINDING | 98 | 98 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
Q | ||||||||
BINDING | 100 | 100 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[IVT] | ||||||||
BINDING | 100 | 100 | /ligand="nicotinamide" /ligand_id="ChEBI:CHEBI:17154" |
[IVT] | ||||||||
BINDING | 101 | 101 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
D | ||||||||
BINDING | 101 | 101 | /ligand="nicotinamide" /ligand_id="ChEBI:CHEBI:17154" |
D | ||||||||
BINDING | 116 | 116 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
H | ||||||||
BINDING | 124 | 124 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 127 | 127 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 148 | 148 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 151 | 151 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
BINDING | 189 | 189 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[ST] | ||||||||
BINDING | 190 | 190 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
S | ||||||||
BINDING | 214 | 214 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
BINDING | 215 | 215 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[LAV] | ||||||||
BINDING | 216 | 216 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G | ||||||||
BINDING | 231 | 231 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[DE] | ||||||||
BINDING | 232 | 232 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[VGIA] |
Additional information
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Size range | 229-260 amino acids |
Related rules |
MF_01121 MF_01967 |
Fusion | Nter: None Cter: None |