HAMAP rule MF_01909
General rule information
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Accession | MF_01909 |
Dates | 29-FEB-2008 (Created)
1-JUN-2023 (Last updated, Version 16) |
Name | TFE_arch |
Scope(s) |
Archaea |
Template(s) | Q980M5 (TFE_SACS2); Q8U3H5 (TFE_PYRFU); O27705 (TFE_METTH); Q58187 (TFE_METJA); [ Recover all ] |
Triggered by |
HAMAP; MF_01909 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TFE |
Protein name | RecName: Full=Transcription factor E; Short=TFE; AltName: Full=TFIIE subunit alpha homolog; AltName: Full=Transcription initiation factor TFIIE; |
Gene name | Name=tfe; |
Comments
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FUNCTION | Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. |
SUBUNIT | Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes. |
DOMAIN | The winged helix domain is involved in binding to DNA in the preinitiation complex. |
SIMILARITY | Belongs to the TFE family. |
Keywords
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Gene Ontology
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GO:0006352; Biological process:DNA-templated transcription initiation |
Cross-references
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Features
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Additional information
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Size range | 139-211 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |