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HAMAP rule MF_01619

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General rule information [?]

Accession MF_01619
Dates 16-NOV-2005 (Created)
26-JAN-2023 (Last updated, Version 21)
Name NAD_malic_enz
Scope(s) Bacteria
Pseudomonadota
Template(s) P26616 (MAO1_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01619 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MAO1
Protein name RecName: Full=NAD-dependent malic enzyme;
                 Short=NAD-ME;
                 EC=1.1.1.38;
Gene name Name=maeA;

Comments [?]

CATALYTIC ACTIVITY Reaction=(S)-malate + NAD(+) = CO2 + NADH + pyruvate; Xref=Rhea:RHEA:12653, ChEBI:CHEBI:15361, ChEBI:CHEBI:15589, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.38;
CATALYTIC ACTIVITY Reaction=H(+) + oxaloacetate = CO2 + pyruvate; Xref=Rhea:RHEA:15641, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526; EC=1.1.1.38;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal cations. Prefers magnesium or manganese.;
SUBUNITHomotetramer.
SIMILARITYBelongs to the malic enzymes family.

Keywords [?]


Gene Ontology [?]

GO:0004471; Molecular function:malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0008948; Molecular function:oxaloacetate decarboxylase activity

Cross-references [?]

PROSITE PS00331; MALIC_ENZYMES; 1;
Pfam PF00390; malic; 1;
Pfam PF03949; Malic_M; 1;
PRINTS PR00072; MALOXRDTASE; 1;

Features [?]

From: MAO1_ECOLI (P26616)
Key From To Description Tag Condition FTGroup
ACT_SITE 104 104 /note="Proton donor" Y
ACT_SITE 175 175 /note="Proton acceptor" K
BINDING 246 246 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
E
BINDING 247 247 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
D
BINDING 270 270 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
D
BINDING 157 157 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
R
BINDING 270 270 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
D
BINDING 418 418 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
N
SITE 270 270 /note="Important for activity"

Additional information [?]

Size range 528-591 amino acids
Related rules None
Fusion Nter: None Cter: None



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