HAMAP rule MF_01594
General rule information
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| Accession | MF_01594 |
| Dates | 1-FEB-2008 (Created)
1-JUN-2023 (Last updated, Version 19) |
| Name | Rhomboid_GlpG |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P09391 (GLPG_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01594 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GLPG |
| Protein name | RecName: Full=Rhomboid protease GlpG; EC=3.4.21.105; AltName: Full=Intramembrane serine protease; |
| Gene name | Name=glpG; |
Comments
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| FUNCTION | Rhomboid-type serine protease that catalyzes intramembrane proteolysis. |
| CATALYTIC ACTIVITY | Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the peptidase S54 family. |
Keywords
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| Cell membrane | |
| Hydrolase | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Membrane | |
| Protease | |
| Serine protease | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0004252; Molecular function:serine-type endopeptidase activity |
| GO:0006508; Biological process:proteolysis |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01694; Rhomboid; 1; |
| NCBIfam | TIGR04239; rhombo_GlpG; 1; |
| General | Transmembrane; -; 6; |
Features
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| From: GLPG_ECOLI (P09391) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 201 | 201 | /note="Nucleophile" | S | ||||||||
| ACT_SITE | 254 | 254 | H | |||||||||
Additional information
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| Size range | 260-300 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Active sites are not conserved in CROS8, suggesting that it has no peptidase activity. |