HAMAP rule MF_01573

General rule information [?]

Accession	MF_01573
Dates	31-OCT-2006 (Created) 1-JUN-2023 (Last updated, Version 15)
Name	Pyl_tRNA_synth
Scope(s)	Archaea Methanosarcinales
Template(s)	Q6WRH6 (PYLS_METBA); Q46E77 (PYLS_METBF); [ Recover all ]
Triggered by	HAMAP; MF_01573 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PYLS
Protein name	RecName: Full=Pyrrolysine--tRNA ligase; EC=6.1.1.26; AltName: Full=Pyrrolysyl-tRNA synthetase; Short=PylRS;
Gene name	Name=pylS;

Comments [?]

FUNCTION	Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
CATALYTIC ACTIVITY	Reaction=ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L- pyrrolysyl-tRNA(Pyl); Xref=Rhea:RHEA:19277, Rhea:RHEA-COMP:9720, Rhea:RHEA-COMP:9721, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58499, ChEBI:CHEBI:78442, ChEBI:CHEBI:78556, ChEBI:CHEBI:456215; EC=6.1.1.26;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class-II aminoacyl-tRNA synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0004812; Molecular function:aminoacyl-tRNA ligase activity

GO:0005524; Molecular function:ATP binding

GO:0006418; Biological process:tRNA aminoacylation for protein translation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]