Search for
You are here: ExPASy CH  > Databases  > Around UniProtKB  > HAMAP

Home Proteomes Families Documents Downloads Links
HAMAP annotation rule: MF_01511

Send feedback new

General rule information

Accession MF_01511
Dates 17-FEB-2004 (Created)
25-NOV-2009 (Last updated, Version 11)
Data class Protein
Predictors HAMAP; MF_01511; [distribution of match scores in UniProtKB];[seed alignment for MF_01511]
Names GMP_reduct_type2


Propagated annotation

Identifier, protein and gene names
Identifier GUAC
Protein name
RecName: Full=GMP reductase;
EC=1.7.1.7;
AltName: Full=Guanosine 5'-monophosphate oxidoreductase;
Short=Guanosine monophosphate reductase;
Gene name guaC
Comments
FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Cross-references
Pfam PF00478; IMPDH; 1;
TIGRFAMs TIGR01306; GMP_reduct_2; 1;
PROSITE PS00487; IMP_DH_GMP_RED; 1;
Keywords
Oxidoreductase, NADP.
Gene Ontology
GO:0003920; Molecular function: GMP reductase activity.
GO:0006163; Biological process: purine nucleotide metabolic process.
Features
From: GUAC_BACSU (O05269)
Key     From     To       Description   Condition   FTGroup
NP_BIND     204     227       NADP (Potential)      
ACT_SITE     175     175       Thioimidate intermediate (By similarity)   C  


Additional information

Size range: 316-330 amino acids
Related UniRules: None
Template: O05269 (GUAC_BACSU)
Scope: Bacteria; Firmicutes
Bacteria; Betaproteobacteria
Bacteria; Campylobacterales
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

View rule in raw text format (no links)



UniProtKB rule member sequences