ExPASy Proteomics Server

Accession	MF_01275
Dates	29-NOV-2006 (Created) 25-NOV-2009 (Last updated, Version 8)

Data class

Protein

Predictors

HAMAP; MF_01275; [distribution of match scores in UniProtKB];[seed alignment for MF_01275]

Names

Aldedh_YdcW

Identifier

ABDH

Protein name

RecName: Full=Gamma-aminobutyraldehyde dehydrogenase; EC=1.2.1.19; AltName: Full=1-pyrroline dehydrogenase; AltName: Full=4-aminobutanal dehydrogenase; Short=ABALDH;

Gene name

ydcW

FUNCTION: Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA) (By similarity).

CATALYTIC ACTIVITY: 4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH.

PATHWAY: Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1.

SUBUNIT: Homotetramer (By similarity).

MISCELLANEOUS: 4-aminobutanal is also called gamma-aminobutyraldehyde.

SIMILARITY: Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.

PROSITE	PS00070; ALDEHYDE_DEHYDR_CYS; 1; PS00687; ALDEHYDE_DEHYDR_GLU; 1;
Pfam	PF00171; Aldedh; 1;

NAD, Oxidoreductase.

GO:0016646; Molecular function: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor.
GO:0051287; Molecular function: NAD or NADH binding.
GO:0009447; Biological process: putrescine catabolic process.

From: ABDH_ECOLI (P77674)
Key		From		To		Description		Condition		FTGroup
NP_BIND		172		175		NAD (By similarity)		K-x-x-E
NP_BIND		225		231		NAD (By similarity)		S-x-x-T-x-x-H
ACT_SITE		246		246		By similarity		E
ACT_SITE		280		280		Nucleophile (By similarity)		C
BINDING		146		146		NAD; via carbonyl oxygen (By similarity)		A
BINDING		209		209		NAD (By similarity)		D

Size range:	474-474 amino acids
Related UniRules:	None
Template:	P77674 (ABDH_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None