HAMAP rule MF_00969

General rule information [?]

Accession	MF_00969
Dates	10-JUL-2013 (Created) 1-JUN-2023 (Last updated, Version 6)
Name	TRCF
Scope(s)	Bacteria
Template(s)	P30958 (MFD_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00969 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MFD
Protein name	RecName: Full=Transcription-repair-coupling factor; Short=TRCF; EC=3.6.4.-;
Gene name	Name=mfd;

Comments [?]

FUNCTION	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	In the N-terminal section; belongs to the UvrB family.
SIMILARITY	In the C-terminal section; belongs to the helicase family. RecG subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0003677; Molecular function:DNA binding

GO:0006355; Biological process:regulation of DNA-templated transcription

GO:0000716; Biological process:transcription-coupled nucleotide-excision repair, DNA damage recognition

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]