HAMAP rule MF_00935
General rule information
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Accession | MF_00935 |
Dates | 18-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 8) |
Name | AlaDH_arch |
Scope(s) |
Archaea Bacteria |
Template(s) | O28608 (ALADH_ARCFU); [ Recover all ] |
Triggered by |
HAMAP; MF_00935 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ALADH |
case <OC:Archaea> | |
Protein name | RecName: Full=Alanine dehydrogenase; Short=AlaDH; EC=1.4.1.1; |
Gene name | Name=ala; |
else case <OC:Bacteria> | |
Protein name | RecName: Full=Putative alanine dehydrogenase; Short=AlaDH; EC=1.4.1.1; |
end case |
Comments
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FUNCTION | Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate. |
CATALYTIC ACTIVITY | Reaction=H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate; Xref=Rhea:RHEA:18405, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57972; EC=1.4.1.1; |
SIMILARITY | Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. |
Keywords
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Gene Ontology
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GO:0000286; Molecular function:alanine dehydrogenase activity |
GO:0051287; Molecular function:NAD binding |
GO:0006522; Biological process:alanine metabolic process |
Cross-references
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Pfam | PF02423; OCD_Mu_crystall; 1; |
NCBIfam | TIGR02371; ala_DH_arch; 1; |
PIRSF | PIRSF001439; CryM; 1; |
Features
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From: ALADH_ARCFU (O28608) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 135 | 136 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
x-Q | ||||||||
BINDING | 157 | 159 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[DN]-x-[RKH] | ||||||||
BINDING | 217 | 219 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G-x-D | ||||||||
ACT_SITE | 65 | 65 | /note="Proton donor/acceptor" | K | ||||||||
BINDING | 108 | 108 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
BINDING | 223 | 223 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K | ||||||||
BINDING | 290 | 290 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
S |
Additional information
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Size range | 291-359 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |