HAMAP rule MF_00638

General rule information [?]

Accession	MF_00638
Dates	17-APR-2003 (Created) 1-JUN-2023 (Last updated, Version 19)
Name	Anti_sigma_B
Scope(s)	Bacteria Bacillales
Template(s)	P17904 (RSBW_BACSU); [ Recover all ]
Triggered by	HAMAP; MF_00638 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RSBW
Protein name	RecName: Full=Serine-protein kinase RsbW; EC=2.7.11.1; AltName: Full=Anti-sigma-B factor; AltName: Full=Sigma-B negative effector RsbW;
Gene name	Name=rsbW;

Comments [?]

FUNCTION	Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
CATALYTIC ACTIVITY	Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CATALYTIC ACTIVITY	Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
SIMILARITY	Belongs to the anti-sigma-factor family.

Keywords [?]

Gene Ontology [?]

GO:0004672; Molecular function:protein kinase activity

GO:0010468; Biological process:regulation of gene expression

Cross-references [?]

Pfam	PF02518; HATPase_c; 1;
NCBIfam	TIGR01924; rsbW_low_gc; 1;

Features [?]

Additional information [?]