Accession	MF_00047
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00047; [distribution of match scores in UniProtKB];[seed alignment for MF_00047]

Identifier

DDL

Protein name

RecName: Full=D-alanine--D-alanine ligase; EC=6.3.2.4; AltName: Full=D-alanylalanine synthetase; AltName: Full=D-Ala-D-Ala ligase;

Gene name

ddl

FUNCTION: Cell wall formation (By similarity).

CATALYTIC ACTIVITY: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

PATHWAY: Cell wall biosynthesis; peptidoglycan biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.

Pfam	PF01820; Dala_Dala_ligas; 1;
TIGRFAMs	TIGR01205; D_ala_D_alaTIGR; 1;
PROSITE	PS00843; DALA_DALA_LIGASE_1; 1; PS00844; DALA_DALA_LIGASE_2; 1; PS50975; ATP_GRASP; 1; trigger=PRU00409;

Cell shape, Cell wall biogenesis/degradation, Cytoplasm, Ligase, Peptidoglycan synthesis.

GO:0008716; Molecular function: D-alanine-D-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	291-396 amino acids
Related UniRules:	None
Template:	P07862 (DDLB_ECOLI); P0A6J8 (DDLA_ECOLI): [Recover all]
Scope:	Bacteria
Fusion:	Nter: MF_00046 (murC); Cter: None
Duplicate:	in BACCR, BRAJA, BRUME, BRUSU, CHRVO, CLOPE, CLOTE, ECOLI, PSEAE, PSEPK, PSESM, RHILO, SALTI, SALTY, SHIFL, XANCP
Plasmid encoded:	None
Comments:	Short BACSU, but does not seem to be extendable