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UniProtKB/Swiss-Prot entry Q9ZL20

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_HELPJ
Primary accession number Q9ZL20
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    July 1, 2008 (Entry version 49)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms EC 1.1.1.3
HDH
Gene name
Name: hom
OrderedLocusNames: jhp_0761
From
Helicobacter pylori J99 (Campylobacter pylori J99) [TaxID: 85963] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/16495; PubMed=9923682 [NCBI, ExPASy, EBI, Israel, Japan]
Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
"Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.";
Nature 397:176-180(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001439; AAD06338.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C71893; C71893.
RefSeq NP_223479.1; -.
3D structure databases
ModBase Q9ZL20.
Enzyme and pathway databases
BioCyc HPYL85963:JHP0761-MON; -.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR016204; hSer_DHase.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF01842; ACT; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000098; Homoser_dehydrog; 1.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS Q9ZL20.
Genome annotation databases
GeneID 890134; -.
GenomeReviews AE001439_GR; jhp_0761.
KEGG hpj:jhp0761; -.
NMPDR fig|85963.1.peg.757; -.
Phylogenomic databases
HOGENOM Q9ZL20; -.
Genome annotation databases
CMR Q9ZL20; jhp_0761.
Other
ProtoNet Q9ZL20.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   421  421     Homoserine dehydrogenase. PRO_0000066695
DOMAIN   342   419  78     ACT. 
NP_BIND   10    17  8     NADP (By similarity). 
ACT_SITE   201   201        Proton donor (Potential). 
BINDING   103   103        NADP (By similarity). 
BINDING   186   186        Substrate (By similarity). 
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 46247 Da [This is the MW of the unprocessed precursor] CRC64: 4DC5921EB61D4A78 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKKRLNIGLV GLGCVGSTVA KILQENQEII KDRAGVEIKI KKAVVRDVKK HKGYAFEISD 

        70         80         90        100        110        120 
DLESVIEDKG IDIVVELMGG VEAPYLLAKK TLAKQKAFVT ANKAMLAYHR YELEQIAKNT 

       130        140        150        160        170        180 
PIGFEASVCG GIPIIKALKD GLSANHILSF KGILNGTSNY ILSQMFKNQA SFKDALKDAQ 

       190        200        210        220        230        240 
HLGYAELNPE FDIKGIDAAH KLLILASLAY GIDAKLEEIL IEGIEKIEPD DMEFAKEFGY 

       250        260        270        280        290        300 
SIKLLGIAKK HQDCIELRVH PSMIKNECML SKVDGVMNAI SVIGDKVGET LYYGAGAGGE 

       310        320        330        340        350        360 
PTASAVISDI IEIARKKSSL MLGFETPQKL PLKPKEEIQC AYYARLLVSD EKGVFSQISA 

       370        380        390        400        410        420 
ILAQNDISLN NVLQKEIPQS NKAKILFSTH TTNEKSMLNA LKELENLQSV LDTPKMIRLE 


N
Q9ZL20 in FASTA format

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