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UniProtKB/Swiss-Prot entry Q9ZFV8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO2_SALTY
Primary accession number Q9ZFV8
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on December 13, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name NADP-dependent malic enzyme
Synonyms NADP-ME
EC 1.1.1.40
Gene name
Name: maeB
OrderedLocusNames: STM2472
From
Salmonella typhimurium [TaxID: 602] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LT2 / SGSC1412 / ATCC 700720;
DOI=10.1038/35101614; PubMed=11677609 [NCBI, ExPASy, EBI, Israel, Japan]
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E., Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.;
"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
Nature 413:852-856(2001).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 610-759.
STRAIN=LT2;
PubMed=10464203 [NCBI, ExPASy, EBI, Israel, Japan]
Kofoid E.C., Rappleye C.A., Stojiljkovic I., Roth J.R.;
"The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.";
J. Bacteriol. 181:5317-5329(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE008811; AAL21366.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF093749; AAC78109.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_461407.1; -.
3D structure databases
ModBase Q9ZFV8.
Enzyme and pathway databases
BioCyc STYP99287:STM2472-MON; -.
Organism-specific databases
StyGene SG10658; maeB.
Ontologies
GO
GO:0004473; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR012188; ME_PTA.
IPR016040; NAD(P)-bd.
IPR002505; PTA_PTB.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
PF01515; PTA_PTB; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036684; ME_PTA; 1.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS Q9ZFV8.
Genome annotation databases
GeneID 1253994; -.
GenomeReviews AE006468_GR; STM2472.
KEGG stm:STM2472; -.
NMPDR fig|99287.1.peg.2388; -.
Phylogenomic databases
HOGENOM Q9ZFV8; -.
Genome annotation databases
CMR Q9ZFV8; STM2472.
Other
ProtoNet Q9ZFV8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; Multifunctional enzyme; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   759  759     NADP-dependent malic enzyme. PRO_0000160244
NP_BIND   76    83  8     NADP (By similarity). 
REGION   1   428  428     Malic enzyme. 
REGION   429   759  331     Phosphate acetyltransferase. 
ACT_SITE   94    94        Proton acceptor (By similarity). 
METAL   136   136        Divalent metal cation (By similarity). 
METAL   137   137        Divalent metal cation (By similarity). 
BINDING   162   162        NAD (By similarity). 
BINDING   288   288        NAD (By similarity). 
CONFLICT   610   610        A -> G (in Ref. 2; AAC78109). 
CONFLICT   613   613        A -> P (in Ref. 2; AAC78109). 
CONFLICT   621   621        R -> H (in Ref. 2; AAC78109). 
CONFLICT   626   626        E -> G (in Ref. 2; AAC78109). 
CONFLICT   635   635        S -> C (in Ref. 2; AAC78109). 
CONFLICT   643   643        L -> P (in Ref. 2; AAC78109). 
CONFLICT   679   679        R -> C (in Ref. 2; AAC78109). 
CONFLICT   754   754        A -> G (in Ref. 2; AAC78109). 
CONFLICT   757   757        T -> Q (in Ref. 2; AAC78109). 
Sequence information
Length: 759 AA [This is the length of the unprocessed precursor] Molecular weight: 82322 Da [This is the MW of the unprocessed precursor] CRC64: D5120B020158EF18 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDEQLKQSAL DFHEFPVPGK IQVSPTKPLA TQRDLALAYS PGVAAPCLEI EKDPLAAYKY 

        70         80         90        100        110        120 
TARGNLVAVI SNGTAVLGLG NIGALAGKPV MEGKGVLFKK FAGIDVFDIE VDELDPDKFI 

       130        140        150        160        170        180 
NVVAALEPTF GGINLEDIKA PECFYIEQKL RERMNIPVFH DDQHGTAIIS TAAILNGLRV 

       190        200        210        220        230        240 
VEKNISDVRM VVSGAGAAAI ACMNLLVALG MQKHNIVVCD SKGVIYKGRE PNMAETKAAY 

       250        260        270        280        290        300 
AVDDSGKRTL DEVIDGADIF LGCSGPKVLT QEMVKKMARA PMILALANPE PEILPPLAKE 

       310        320        330        340        350        360 
VRPDAIICTG RSDYPNQVNN VLCFPFIFRG ALDVGATAIN EEMKLAAVRA IAELAHAEQS 

       370        380        390        400        410        420 
EVVASAYGDQ DLSFGPEYII PKPFDPRLIV KIAPAVAKAA MDSGVATRPI ADFDAYIDKL 

       430        440        450        460        470        480 
TEFVYKTNLF MKPIFSQARK DPKRVVLPEG EEARVLHATQ ELITLGLAKP ILIGRPSVIE 

       490        500        510        520        530        540 
MRIQKLGLQI KAGVDFEIVN NESDPRFKEY WSEYYQIMKR RGITQEQAQR AMIGNHTAIG 

       550        560        570        580        590        600 
AIMVQRGEAD AMICGTIGDY HEHFSVVKAV FGYRDGVHTA GAMNALLLPS GNTFIADTYV 

       610        620        630        640        650        660 
NEDPTPEQLA EIAVMAAETV RRFGIEPKVA LLSHSNFGSS NSLSASKMRE TLERVRERAP 

       670        680        690        700        710        720 
DLMIDGEMHG DAALVESIRN DRMPDSPLKG AANILVMPNM EAARISYNLL RVSSSEGVTV 

       730        740        750 
GPVLMGVSKP VHVLTPIASV RRIVNMVALA VVEAQTTPL
Q9ZFV8 in FASTA format

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