NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Madrid E;
DOI=10.1038/24094; PubMed=9823893 [NCBI, ExPASy, EBI, Israel, Japan]
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.;
"The genome sequence of Rickettsia prowazekii and the origin of mitochondria.";
Nature 396:133-140(1998).

Comments

CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor.
COFACTOR: Binds 1 2Fe-2S cluster.
COFACTOR: Binds 1 3Fe-4S cluster.
COFACTOR: Binds 1 4Fe-4S cluster.
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ235270; CAA14515.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D71712; D71712.

RefSeq

NP_220438.1; -.

3D structure databases

HSSP

P07014; 1NEK. [HSSP ENTRY / PDB]

ModBase

Q9ZEA1.

Enzyme and pathway databases

BioCyc

RPRO272947:RP044-MON; -.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF00111; Fer2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9ZEA1.

Genome annotation databases

GeneID

883577; -.

GenomeReviews

AJ235269_GR; RP044.

KEGG

rpr:RP044; -.

Phylogenomic databases

HOGENOM

Q9ZEA1; -.

Genome annotation databases

CMR

Q9ZEA1; RP044.

Other

ProtoNet

Q9ZEA1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 261`	`261`	`Succinate dehydrogenase iron-sulfur subunit.`	`PRO_0000158691`
`DOMAIN`	`28 119`	`92`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`161 191`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`80 80`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`85 85`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`88 88`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`100 100`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`171 171`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`174 174`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`177 177`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`181 181`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`228 228`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`234 234`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`238 238`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`

Sequence information

Length: 261 AA [This is the length of the unprocessed precursor]

Molecular weight: 29572 Da [This is the MW of the unprocessed precursor]

CRC64: AFAB638FFF0F44A1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVELRLPSNS VVKKGREHKA QQKMLKPRKV KVYRYDPDLD ENPTIDSFEI DLSKTGPMVL 

        70         80         90        100        110        120 
DALIKIKNEI DSTLTFRRSC REGICGSCAM NIDGTNTLAC IKPIEDISGD IKIYPLPHMK 

       130        140        150        160        170        180 
VVKDLVPDMS HFYAQYESIE PWLKNDSPAP SNSERLQSIK DREKLDGLYE CILCACCSTS 

       190        200        210        220        230        240 
CPSYWWNGDK YLGPAILLQA YRWIADSRDD NTGARLEALE DPFKLYRCHT IMNCTKTCPK 

       250        260 
GLNPAKAIGR VKNLIAERHG V

Q9ZEA1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools