ID   ILVC1_STRCO             Reviewed;         332 AA.
AC   Q9Z565;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-NOV-2008, entry version 58.
DE   RecName: Full=Ketol-acid reductoisomerase 1;
DE            EC=1.1.1.86;
DE   AltName: Full=Acetohydroxy-acid isomeroreductase 1;
DE   AltName: Full=Alpha-keto-beta-hydroxylacil reductoisomerase 1;
GN   Name=ilvC1; Synonyms=ilvC; OrderedLocusNames=SCO5514;
GN   ORFNames=SC8D9.26;
OS   Streptomyces coelicolor.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   MEDLINE=21996410; PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)
CC       = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
CC   -!- CATALYTIC ACTIVITY: (2R,3R)-2,3-dihydroxy-3-methylpentanoate +
CC       NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 2/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 2/4.
CC   -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
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DR   EMBL; AL939124; CAB37590.1; -; Genomic_DNA.
DR   PIR; T35830; T35830.
DR   RefSeq; NP_629649.1; -.
DR   HSSP; Q9HVA2; 1NP3.
DR   GeneID; 1100954; -.
DR   GenomeReviews; AL645882_GR; SCO5514.
DR   KEGG; sco:SCO5514; -.
DR   NMPDR; fig|100226.1.peg.5466; -.
DR   HOGENOM; Q9Z565; -.
DR   BioCyc; SCOE100226:SCO5514-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004455; F:ketol-acid reductoisomerase activity; IEA:HAMAP.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00435; -; 1.
DR   InterPro; IPR013023; AcH_isomrdctse.
DR   InterPro; IPR000506; AcH_isomrdctse_C.
DR   InterPro; IPR013116; IlvN.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR21371; AcH_isomrdctse; 1.
DR   Pfam; PF01450; IlvC; 1.
DR   Pfam; PF07991; IlvN; 1.
DR   TIGRFAMs; TIGR00465; ilvC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    332       Ketol-acid reductoisomerase 1.
FT                                /FTId=PRO_0000151363.
FT   ACT_SITE    108    108       Potential.
SQ   SEQUENCE   332 AA;  36254 MW;  84D0A2E698B3504E CRC64;
     MAELFYDADA DLSIIQGRKV AVIGYGSQGH AHALSLRDSG VDVRVGLHEG SKSKAKAEEQ
     GLRVVPVAEA AAEADVIMIL VPDPIQAEVY EKDIKDNLKD GDALFFGHGL NIRYGFIKPP
     AGVDVCMVAP KGPGHLVRRQ YEEGRGVPCI AAVEQDATGN AFALALSYAK GIGGTRAGVI
     KTTFTEETET DLFGEQAVLC GGTAALVKAG FETLTEAGYQ PEIAYFECLH ELKLIVDLMY
     EGGLEKMRWS ISETAEWGDY VTGPRIITDA TKAEMKKVLA EIQDGTFAKN WMDEYHGGLK
     KYNEYKKQDS EHLLETTGKE LRKLMSWVDE EA
//