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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PLD1A AND PLD1B).
STRAIN=129;
TISSUE=Embryonic brain, and Neonatal brain;
PubMed=9307024 [NCBI, ExPASy, EBI, Israel, Japan]
Colley W.C.,
Altshuller Y.M.,
Sue-Ling C.K.,
Copeland N.G.,
Gilbert D.J.,
Jenkins N.A.,
Branch K.D.,
Tsirka S.E.,
Bollag R.J.,
Bollag W.B.,
Frohman M.A.;
"Cloning and expression analysis of murine phospholipase D1.";
Biochem. J. 326:745-753(1997).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM PLD1A).
STRAIN=129;
DOI=10.1016/S0378-1119(98)00465-X; PubMed=9813240 [NCBI, ExPASy, EBI, Israel, Japan]
Redina O.E.,
Frohman M.A.;
"Genomic analysis of murine phospholipase D1 and comparison to phospholipase D2 reveals an unusual difference in gene size.";
Gene 222:53-60(1998).
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[3]
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SUBCELLULAR LOCATION.
DOI=10.1016/S0960-9822(97)70090-3; PubMed=9395408 [NCBI, ExPASy, EBI, Israel, Japan]
Colley W.C.,
Sung T.-C.,
Roll R.,
Jenco J.M.,
Hammond S.M.,
Altshuller Y.M.,
Bar-Sagi D.,
Morris A.J.,
Frohman M.A.;
"Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.";
Curr. Biol. 7:191-201(1997).
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[4]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr0604155; PubMed=17203969 [NCBI, ExPASy, EBI, Israel, Japan]
Dai J.,
Jin W.-H.,
Sheng Q.-H.,
Shieh C.-H.,
Wu J.-R.,
Zeng R.;
"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.";
J. Proteome Res. 6:250-262(2007).
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- FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic.
- CATALYTIC ACTIVITY: A phosphatidylcholine + H2O = choline + a phosphatidate.
- ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42.
- SUBUNIT: Interacts with PIP5K1A (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side (Potential). Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side (Potential). Late endosome membrane; Lipid-anchor; Cytoplasmic side (Potential).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | PLD1B |
| Isoform ID | Q9Z280-2 |
| Features which should be applied to build the isoform sequence: VSP_005023. |
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- TISSUE SPECIFICITY: Expressed in kidney, lung, and at a much lower levels, in brain, liver, heart, testis and spleen.
- DEVELOPMENTAL STAGE: Expressed most strikingly in selected ventricular cells lining the spinal cord and brain. The level of expression decreases dramatically as the cells differentiate into neurons and migrate to the outer layer of the spinal cord and brain. Expression is observed during development in a restricted region of the nasal neuroepithelium.
- DISEASE: Defects in Pld1 may result in coa which is associated with coat color dilution and white spotting. It is also associated with platelet-storage pool deficiency characterized by decreased levels in serotonin and dense granules.
- SIMILARITY: Belongs to the phospholipase D family.
- SIMILARITY: Contains 1 PH domain.
- SIMILARITY: Contains 2 PLD phosphodiesterase domains.
- SIMILARITY: Contains 1 PX (phox homology) domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1074 AA [This is the length of the unprocessed precursor] |
Molecular weight: 123969 Da [This is the MW of the unprocessed precursor] |
CRC64: E11260982A217280 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSLKSETRVN TSTLQKIAAD MSNLIENLDT RELHFEGEEV EYDASPGDPK AQEGCIPFSS
70 80 90 100 110 120
IYNTQGFKEP NIQTYLSGCP IKAQVLEVER FTSTSRVPSI NLYTIELTHG EFTWQVKRKF
130 140 150 160 170 180
KHFQEFHREL LKYKAFIRIP IPTKRHTFRR QNVKEEPREM PSLPRSSENA IQEEQFFGRR
190 200 210 220 230 240
KQLEDYLTKI LKMPMYRNYH ATTEFLDVSQ LSFIHDLGPK GLEGMIMKRS GGHRIPGVNC
250 260 270 280 290 300
CGHGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFRVKVGRKE TETKYGLRID
310 320 330 340 350 360
NLSRTLILKC NSYRHARWWG GAIEEFIRKH GADFLKDHRF GSYAALHENT LAKWYVNAKG
370 380 390 400 410 420
YFEDIANAME EASEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY
430 440 450 460 470 480
KEVELALGIN SEYSKRTLMR LHPNIKVMRH PDHVSSSVYL WAHHEKLVII DQSVAFVGGI
490 500 510 520 530 540
DLAYGRWDDN EHRLTDVGSV KRVTSGLSLG SLTAASVESM ESLSLKDKHE FHKKEPISKI
550 560 570 580 590 600
VDETDMKLKG IGKSRKFSKF SLYRQLHRHH LHNADSISSI DSTSSYFSHC RSHQNLIHGL
610 620 630 640 650 660
KPHLKLFHPS SESEQGLTRH STDTGSIRSV QTGVGELHGE TRFWHGKDYC NFVFKDWVQL
670 680 690 700 710 720
DKPFADFIDR YSTPRMPWHD IGSVVHGKAA RDVARHFIQR WNFTKIMKPK YRSLSYPFLL
730 740 750 760 770 780
PKSQATAHEL RYQVPGAVPA KVQLLRSAAD WSAGIKHHEE SIHAAYIHVI ENSKHYIYIE
790 800 810 820 830 840
NQFFISCADD KVVFNKVGDR IAQRILKAHR EGQRYRVYIV IPLLPGFEGD ISTGGGNALQ
850 860 870 880 890 900
AIMHFNYRTM CRGESSILEQ LKPELGNKWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL
910 920 930 940 950 960
IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR FARDLRLECF
970 980 990 1000 1010 1020
RLVLGYLSDP SEDLQDPVSD KFFKEIWVST AARNATIYDK VFRCLPNDEV HNLIQLRDFI
1030 1040 1050 1060 1070
NKPILAKEDA LRAEEELRKI RGFLVQFPLY FLSEENLLPS VGTKEAIVPM EVWT
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Q9Z280 in FASTA format |
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