ID   GIPC1_RAT               Reviewed;         333 AA.
AC   Q9Z254; Q6GR70; Q9QUQ4;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   25-NOV-2008, entry version 54.
DE   RecName: Full=PDZ domain-containing protein GIPC1;
DE   AltName: Full=RGS19-interacting protein 1;
DE   AltName: Full=GAIP C-terminus-interacting protein;
DE   AltName: Full=RGS-GAIP-interacting protein;
DE   AltName: Full=GLUT1 C-terminal-binding protein;
DE            Short=GLUT1CBP;
GN   Name=Gipc1; Synonyms=Gipc, Rgs19ip1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH RGS19.
RC   TISSUE=Pituitary;
RX   MEDLINE=98445373; PubMed=9770488; DOI=10.1073/pnas.95.21.12340;
RA   De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G.;
RT   "GIPC, a PDZ domain containing protein, interacts specifically with
RT   the C-terminus of RGS-GAIP.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH ACTN1; GLUT1; KIF1B
RP   AND MYO6.
RC   STRAIN=Fischer 344; TISSUE=Brain;
RX   MEDLINE=99213979; PubMed=10198040;
RA   Bunn R.C., Jensen M.A., Reed B.C.;
RT   "Protein interactions with the glucose transporter binding protein
RT   GLUT1CBP that provide a link between GLUT1 and the cytoskeleton.";
RL   Mol. Biol. Cell 10:819-832(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INTERACTION WITH PLEKHG5.
RX   PubMed=16467373; DOI=10.1091/mbc.E06-01-0002;
RA   Liu M., Horowitz A.;
RT   "A PDZ-binding motif as a critical determinant of Rho guanine exchange
RT   factor function and cell phenotype.";
RL   Mol. Biol. Cell 17:1880-1887(2006).
CC   -!- FUNCTION: May be involved in G protein-linked signaling (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C
CC       (By similarity). Interacts with RGS19 (C-terminus), GLUT1 (C-
CC       terminus), ACTN1, KIF1B, MYO6 and PLEKHG5.
CC   -!- INTERACTION:
CC       P08588:ADRB1 (xeno); NbExp=1; IntAct=EBI-991162, EBI-991009;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane;
CC       Peripheral membrane protein (By similarity).
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Belongs to the GIPC family.
CC   -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
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DR   EMBL; AF089817; AAC67549.1; -; mRNA.
DR   EMBL; AF032120; AAC69268.1; -; mRNA.
DR   EMBL; BC070505; AAH70505.1; -; mRNA.
DR   RefSeq; NP_445793.1; -.
DR   UniGene; Rn.30044; -.
DR   HSSP; P29476; 1QAV.
DR   IntAct; Q9Z254; -.
DR   Ensembl; ENSRNOG00000003864; Rattus norvegicus.
DR   GeneID; 83823; -.
DR   KEGG; rno:83823; -.
DR   RGD; 68338; Gipc1.
DR   HOVERGEN; Q9Z254; -.
DR   NextBio; 616438; -.
DR   ArrayExpress; Q9Z254; -.
DR   GermOnline; ENSRNOG00000003864; Rattus norvegicus.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR017379; UCP038083_PDZ.
DR   Pfam; PF00595; PDZ; 1.
DR   PIRSF; PIRSF038083; UCP038083_GIPC; 1.
DR   SMART; SM00228; PDZ; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Membrane.
FT   CHAIN         1    333       PDZ domain-containing protein GIPC1.
FT                                /FTId=PRO_0000087494.
FT   CONFLICT    253    253       V -> I (in Ref. 1; AAC67549).
FT   CONFLICT    270    270       D -> E (in Ref. 1; AAC67549).
SQ   SEQUENCE   333 AA;  36133 MW;  2DE14E6839A218D6 CRC64;
     MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSGA GESQMGLPPP PASLRPRLVF
     HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC TLNTHKVDMD KLLGGQIGLE
     DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA
     INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSSGGHP GSGPQLGTGR
     GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
     AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
//