[1]	NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH RGS19. TISSUE=Pituitary; DOI=10.1073/pnas.95.21.12340; PubMed=9770488 [NCBI, ExPASy, EBI, Israel, Japan] De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G.; "GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP."; Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998).
[2]	NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH ACTN1; GLUT1; KIF1B AND MYO6. STRAIN=Fischer 344; TISSUE=Brain; PubMed=10198040 [NCBI, ExPASy, EBI, Israel, Japan] Bunn R.C., Jensen M.A., Reed B.C.; "Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton."; Mol. Biol. Cell 10:819-832(1999).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Lung; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	INTERACTION WITH PLEKHG5. DOI=10.1091/mbc.E06-01-0002; PubMed=16467373 [NCBI, ExPASy, EBI, Israel, Japan] Liu M., Horowitz A.; "A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype."; Mol. Biol. Cell 17:1880-1887(2006).

Comments

FUNCTION: May be involved in G protein-linked signaling (By similarity).
SUBUNIT: Interacts with SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 (C-terminus), GLUT1 (C-terminus), ACTN1, KIF1B, MYO6 and PLEKHG5.
INTERACTION:
P08588:ADRB1 (xeno); NbExp=1; IntAct=EBI-991162, EBI-991009;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the GIPC family.
SIMILARITY: Contains 1 PDZ (DHR) domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF089817; AAC67549.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF032120; AAC69268.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC070505; AAH70505.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_445793.1; -.

UniGene

Rn.30044

3D structure databases

HSSP

P29476; 1QAV. [HSSP ENTRY / PDB]

ModBase

Q9Z254.

Protein-protein interaction databases

IntAct

Q9Z254; -.

Organism-specific databases

RGD

68338; Gipc1.

Gene expression databases

ArrayExpress

Q9Z254; -.

GermOnline

ENSRNOG00000003864; Rattus norvegicus.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.

Family and domain databases

InterPro

IPR001478; PDZ.
IPR017379; UCP038083_PDZ.
Graphical view of domain structure.

Pfam

PF00595; PDZ; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF038083; UCP038083_GIPC; 1.

SMART

SM00228; PDZ; 1.
SMART graphical view of domain structure.

PROSITE

PS50106; PDZ; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9Z254.

Genome annotation databases

Ensembl

ENSRNOG00000003864; Rattus norvegicus. [Contig view]

GeneID

83823; -.

KEGG

rno:83823; -.

Phylogenomic databases

HOVERGEN

Q9Z254; -.

Other

ProtoNet

Q9Z254.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Membrane.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 333`	`333`	`PDZ domain-containing protein GIPC1.`	`PRO_0000087494`
`CONFLICT`	`253 253`		`V -> I (in Ref. 1; AAC67549).`
`CONFLICT`	`270 270`		`D -> E (in Ref. 1; AAC67549).`

Sequence information

Length: 333 AA [This is the length of the unprocessed precursor]

Molecular weight: 36133 Da [This is the MW of the unprocessed precursor]

CRC64: 2DE14E6839A218D6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPLGLGRRKK APPLVENEEA EPSRSGLGVG EPGPLGGSGA GESQMGLPPP PASLRPRLVF 

        70         80         90        100        110        120 
HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPAAEVMFC TLNTHKVDMD KLLGGQIGLE 

       130        140        150        160        170        180 
DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIQ LISVGDMIEA 

       190        200        210        220        230        240 
INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSSGGHP GSGPQLGTGR 

       250        260        270        280        290        300 
GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 

       310        320        330 
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY

Q9Z254 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools