ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q9Z244

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GMPR1_RAT
Primary accession number Q9Z244
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 54)
Name and origin of the protein
Protein name GMP reductase 1
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase 1
Guanosine monophosphate reductase 1
Gene name
Name: Gmpr
Synonyms: Gmpr1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Brown adipose tissue;
DOI=10.1074/jbc.273.47.31092; PubMed=9813009 [NCBI, ExPASy, EBI, Israel, Japan]
Salvatore D., Bartha T., Larsen P.R.;
"The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure.";
J. Biol. Chem. 273:31092-31096(1998).
Comments
  • FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  • CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH.
  • SUBUNIT: Homotetramer (By similarity).
  • SIMILARITY: Belongs to the IMPDH/GMPR family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF090867; AAC78657.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_476536.1; -.
UniGene Rn.3862
3D structure databases
HSSP P50099; 1ZFJ. [HSSP ENTRY / PDB]
SMR Q9Z244; 1-343.
ModBase Q9Z244.
Organism-specific databases
RGD 70980; Gmpr.
Gene expression databases
ArrayExpress Q9Z244; -.
GermOnline ENSRNOG00000017250; Rattus norvegicus.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from InterPro).
GO:0030955; Molecular function: potassium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009117; Biological process: nucleotide metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR005993; GMP_reduct1.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000235; GMP_reductase; 1.
TIGRFAMs TIGR01305; GMP_reduct_1; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
ProtoNet Q9Z244.
Genome annotation databases
Ensembl ENSRNOG00000017250; Rattus norvegicus. [Contig view]
GeneID 117533; -.
KEGG rno:117533; -.
Phylogenomic databases
HOVERGEN Q9Z244; -.
Other
NextBio 620325; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Metal-binding; NADP; Oxidoreductase; Potassium.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   345  345     GMP reductase 1. PRO_0000093725
NP_BIND   108   131  24     NADP (By similarity). 
ACT_SITE   186   186        Thioimidate intermediate (By similarity). 
METAL   181   181        Potassium; via carbonyl oxygen (By similarity). 
METAL   183   183        Potassium; via carbonyl oxygen (By similarity). 
BINDING   219   219        NADP (By similarity). 
Sequence information
Length: 345 AA [This is the length of the unprocessed precursor] Molecular weight: 37488 Da [This is the MW of the unprocessed precursor] CRC64: 8B35AE591E32B3EE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPRIDADLKL DFKDVLLRPK RSSLKSRSEV DLERTFTFRN SKQTYSGIPV IVANMDTVGT 

        70         80         90        100        110        120 
FEMAVVMSQH AMFTAIHKHY SLDDWKHFAE NHPECLQHVA VSSGSGQNDL EKMSLILEAV 

       130        140        150        160        170        180 
PQVKFICLDV ANGYSEHFVE FVKLVRSKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV 

       190        200        210        220        230        240 
GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG SCTCPGDVAK AFGAGADFVM 

       250        260        270        280        290        300 
LGGMFSGHTE CAGEVIERNG QKLKLFYGMS SDTAMKKHAG GVAEYRASEG KTVEVPYKGD 

       310        320        330        340 
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFG
Q9Z244 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!