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UniProtKB/Swiss-Prot entry Q9Z1W8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT12A_MOUSE
Primary accession number Q9Z1W8
Secondary accession number Q8VHY2
Integrated into Swiss-Prot on January 23, 2002
Sequence was last modified on August 16, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 65)
Name and origin of the protein
Protein name Potassium-transporting ATPase alpha chain 2
Synonyms EC 3.6.3.10
Proton pump
Non-gastric H(+)/K(+) ATPase subunit alpha
Gene name
Name: Atp12a
Synonyms: Atp1al1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
PubMed=11729223 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang W., Kuncewicz T., Higham S.C., Kone B.C.;
"Structure, promoter analysis, and chromosomal localization of the murine H(+)/K(+)-ATPase alpha 2 subunit gene.";
J. Am. Soc. Nephrol. 12:2554-2564(2001).
[2]
 PROTEIN SEQUENCE OF 488-498; 624-636; 710-718 AND 755-785, AND MASS SPECTROMETRY.
STRAIN=C57BL/6;
TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[3]
 NUCLEOTIDE SEQUENCE [MRNA] OF 868-981, AND TISSUE SPECIFICITY.
STRAIN=C57BL/6;
TISSUE=Skin;
DOI=10.1016/S0014-5793(98)01483-5; PubMed=9872395 [NCBI, ExPASy, EBI, Israel, Japan]
Pestov N.B., Romanova L.G., Korneenko T.V., Egorov M.V., Kostina M.B., Sverdlov V.E., Askari A., Shakhparonov M.I., Modyanov N.N.;
"Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit.";
FEBS Lett. 440:320-324(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF350499; AAL68709.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF100169; AAD03421.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.273271
3D structure databases
HSSP P06685; 1MO7. [HSSP ENTRY / PDB]
ModBase Q9Z1W8.
PTM databases
PhosphoSite Q9Z1W8; -.
Organism-specific databases
MGI MGI:1926943; Atp12a.
Gene expression databases
ArrayExpress Q9Z1W8; -.
GermOnline ENSMUSG00000022229; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0008900; Molecular function: hydrogen:potassium-exchanging ATPase activity (inferred from electronic annotation from EC).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030955; Molecular function: potassium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
GO:0055075; Biological process: potassium ion homeostasis (inferred from mutant phenotype from MGI).
GO:0006813; Biological process: potassium ion transport (inferred from electronic annotation from UniProtKB-KW).
GO:0015992; Biological process: proton transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006069; ATPase_cat_a.
IPR005775; ATPase_cat_a_euk.
IPR001757; ATPase_P.
IPR006068; ATPase_P_cat_C.
IPR004014; ATPase_P_cat_N.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00689; Cation_ATPase_C; 1.
PF00690; Cation_ATPase_N; 1.
PF00122; E1-E2_ATPase; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00121; NAKATPASE.
TIGRFAMs TIGR01106; ATPase-IIC_X-K; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet Q9Z1W8.
Genome annotation databases
Ensembl ENSMUSG00000022229; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q9Z1W8; -.
HOVERGEN Q9Z1W8; -.
Other
SOURCE Atp12a; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Direct protein sequencing; Hydrogen ion transport; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Potassium; Potassium transport; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1035  1035     Potassium-transporting ATPase alpha chain 2. PRO_0000046261
TOPO_DOM   1     99  99     Cytoplasmic (Potential). 
TRANSMEM   100    120  21     Potential. 
TOPO_DOM   121    142  22     Lumenal (Potential). 
TRANSMEM   143    163  21     Potential. 
TOPO_DOM   164    299  136     Cytoplasmic (Potential). 
TRANSMEM   300    319  20     Potential. 
TOPO_DOM   320    331  12     Lumenal (Potential). 
TRANSMEM   332    349  18     Potential. 
TOPO_DOM   350    783  434     Cytoplasmic (Potential). 
TRANSMEM   784    803  20     Potential. 
TOPO_DOM   804    813  10     Lumenal (Potential). 
TRANSMEM   814    834  21     Potential. 
TOPO_DOM   835    854  20     Cytoplasmic (Potential). 
TRANSMEM   855    877  23     Potential. 
TOPO_DOM   878    929  52     Lumenal (Potential). 
TRANSMEM   930    949  20     Potential. 
TOPO_DOM   950    963  14     Cytoplasmic (Potential). 
TRANSMEM   964    982  19     Potential. 
TOPO_DOM   983    997  15     Lumenal (Potential). 
TRANSMEM   998   1018  21     Potential. 
TOPO_DOM   1019   1035  17     Cytoplasmic (Potential). 
ACT_SITE   387    387        4-aspartylphosphate intermediate (By similarity). 
METAL   728    728        Magnesium (By similarity). 
METAL   732    732        Magnesium (By similarity). 
MOD_RES   954    954        Phosphoserine; by PKA (By similarity). 
CONFLICT   975    975        I -> M (in Ref. 3; AAD03421). 
CONFLICT   981    981        S -> F (in Ref. 3; AAD03421). 
Sequence information
Length: 1035 AA [This is the length of the unprocessed precursor] Molecular weight: 114726 Da [This is the MW of the unprocessed precursor] CRC64: 6FF6E26F52BE1EC4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRRKTEIYSV ELNGTKDVEL ADQKDDKKFK GGKNKDSEPN KSQEEELKKE LDLDDHRLSN 

        70         80         90        100        110        120 
TDLEQKYGTN IIQGLSSIRA AELLARDGPN ALTPPKQTPE IIKFLKQMVG GFSILLWIGA 

       130        140        150        160        170        180 
ALCWIAYVIQ YVSSTASLDN VYLGAILVLV VILTGIFAYY QEAKSTNIMA SFSKMIPQQA 

       190        200        210        220        230        240 
LVIRDAEKKI IPAEQLVVGD VVEIKGGDQI PADIRLVFSQ GCKVDNSSLT GESEPQARST 

       250        260        270        280        290        300 
EFTHENPLET KNIGFYSTTC LEGTATGIVI NTGDRTIIGR IASLASGVGS EKTPIAIEIE 

       310        320        330        340        350        360 
HFVHIVAAVA VSVGVIFFIT AVCMKYYVLD AIIFLISIIV ANVPEGLLAT VTVTLSLTAK 

       370        380        390        400        410        420 
RMAKKNCLVK NLEAVETLGS TSIICSDKTG TLTQNRMTVA HLWFDNQIFV ADTSENQTKQ 

       430        440        450        460        470        480 
AFDQSSGTWA SLSKIITLCN RAEFRPGQES VPIMKRVVVG DASKTALLKF SEVILGDVMD 

       490        500        510        520        530        540 
IRKRNHKVAE IPFNSTNKFQ LSIHETEDPN DKRFLMVMKG APERILEKCS TIMINGQEQP 

       550        560        570        580        590        600 
LDKSSADAFH TAYMELGGLG ERVLGFCHLY LPADKFPQSY TFDVDSINFP TSNLCFVGLL 

       610        620        630        640        650        660 
SMIDPPRSTV PDAVSKCRSA GIKVIMVTGD HPITAKAIAK SVGIISANNE TVEDIAKRRN 

       670        680        690        700        710        720 
IAVEQVNKRE AKAAVVTGME LKDMTPEQLD ELLINYQEIV FARTSPQQKL IIVEGCQRQD 

       730        740        750        760        770        780 
AVVAVTGDGV NDSPALKKAD IGIAMGIAGS DAAKNAADMV LLDDNFASIV TGVEEGRLIF 

       790        800        810        820        830        840 
DNLKKTIAYT LTKNIAELCP FLIYIVAGLP LPIGTITILF IDLGTDIIPS IALAYEKAES 

       850        860        870        880        890        900 
DIMNRKPRHK KKDRLVNKQL AIYSYLHIGL MQALGGFLVY FTVYAQQGFW PTSLINLRVS 

       910        920        930        940        950        960 
WETDDINDLE DSYGQEWTRY QRKYLEWTGS TAFFVAIMVQ QIADLIIRKT RRNSIFQQGL 

       970        980        990       1000       1010       1020 
FRNKVIWVGI ISQIIVALVL SYGLGSVTAL SFTMLRAQYW FVAVPHAILI WVYDEMRKLF 

      1030 
IRLYPGSWWD KNMYY
Q9Z1W8 in FASTA format

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