[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Isolate Tucson; PubMed=9847359 [NCBI, ExPASy, EBI, Israel, Japan] Afonso C.L., Tulman E.R., Lu Z., Oma E., Kutish G.F., Rock D.L.; "The genome of Melanoplus sanguinipes entomopoxvirus."; J. Virol. 73:533-552(1999).

Comments

FUNCTION: Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
SIMILARITY: Belongs to the helicase family. NPH I subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF063866; AAC97824.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T28214; T28214.

RefSeq

NP_048124.1; -.

3D structure databases

ModBase

Q9YW39.

Ontologies

GO:0017111;	Molecular function: nucleoside-triphosphatase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR013676; NPHI_C.
IPR000330; SNF2_N.
Graphical view of domain structure.

Pfam

PF00271; Helicase_C; 1.
PF08469; NPHI_C; 1.
PF00176; SNF2_N; 1.
Pfam graphical view of domain structure.

SMART

SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.

PROSITE

PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9YW39.

Genome annotation databases

GeneID

1449819; -.

Other

ProtoNet

Q9YW39.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Hydrolase; Nucleotide-binding; Transcription.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 647`	`647`	`Nucleoside triphosphatase I.`	`PRO_0000099103`
`DOMAIN`	`48 213`	`166`	`Helicase ATP-binding.`
`DOMAIN`	`377 540`	`164`	`Helicase C-terminal.`
`NP_BIND`	`61 68`	`8`	`ATP (By similarity).`
`MOTIF`	`150 153`	`4`	`DEXH box.`

Sequence information

Length: 647 AA [This is the length of the unprocessed precursor]

Molecular weight: 75135 Da [This is the MW of the unprocessed precursor]

CRC64: E78C7F768235D51D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHSIEHIVAR HFNYALEKTK DLPKSINNEI TNEIIILKDY QYLVSRIFIG LSELNSLLLF 

        70         80         90        100        110        120 
WDTGYGKTLT SVYIMKHLKL VFPQWFFVIF IKKSLYVDPW LNTLSKLGMK GQNIKFVLYD 

       130        140        150        160        170        180 
SSSSLKQFNV LYRTIISSIN TKNRILIIID EVHQVISRTI EKSSSTQRNF LSIFNKIVKL 

       190        200        210        220        230        240 
ANSENNKLLC MSATPITNNV LEFKYLINLL RPKIIEFKED FIVNNTLKNH EQLKNGLISI 

       250        260        270        280        290        300 
TSYQKISEAD SFTNTSYTEG FASKNIFYHN VTMTPEQSNI FNIADKHDKK SALGGLKTMR 

       310        320        330        340        350        360 
RLVSSFAFYD IKIKGSMSQI EYNKMVSEKL NEFKSIIGNF KFSNEFIDIF RNNDSFSNAK 

       370        380        390        400        410        420 
SSEIEIFDKI KQYSCKYIEA CKIILNSNGK VLLYEPLVSF EGISTLKIYF NIFNISYVEY 

       430        440        450        460        470        480 
SSKTESTRDY NIDIFNKYDN LYGNKIKVCI FSAAGSEGIS FSSINDIIIL DLPWKESDIK 

       490        500        510        520        530        540 
QIIGRSIRLN SHEELPIEKR YVNVHFIIAS TIDGKSVDKE IFDLIKSKQD KINVLNSFMK 

       550        560        570        580        590        600 
VISIEQIHSK YKYAEPVENE YIFNNIRHTK IDDVNENNVI TKIIVSPIYY CSEDNLNIIY 

       610        620        630        640 
NGYLDKKTGI IYSNNIPIAK LILDENNIYK FFIKDDKLVY ITKSIYE

Q9YW39 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools