[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Isolate Tucson; PubMed=9847359 [NCBI, ExPASy, EBI, Israel, Japan] Afonso C.L., Tulman E.R., Lu Z., Oma E., Kutish G.F., Rock D.L.; "The genome of Melanoplus sanguinipes entomopoxvirus."; J. Virol. 73:533-552(1999).

Comments

FUNCTION: Essential for viral replication. Plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Acts as NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for propagation of viral particles (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF063866; AAC97810.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T28247; T28247.

RefSeq

NP_048157.1; -.

3D structure databases

ModBase

Q9YW06.

Family and domain databases

InterPro

IPR003593; AAA+_ATPase_core.
IPR014001; DEAD-like_N.
IPR001650; DNA/RNA_helicase_C.
IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464; DNA/RNA_helicase_DEAH_CS.
IPR014021; Helicase_SF1/SF2_ATP-bd.
Graphical view of domain structure.

Pfam

PF00270; DEAD; 1.
PF00271; Helicase_C; 1.
Pfam graphical view of domain structure.

SMART

SM00382; AAA; 1.
SM00487; DEXDc; 1.
SM00490; HELICc; 1.
SMART graphical view of domain structure.

PROSITE

PS00690; DEAH_ATP_HELICASE; FALSE_NEG.
PS51192; HELICASE_ATP_BIND_1; 1.
PS51194; HELICASE_CTER; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9YW06.

Genome annotation databases

GeneID

1449805; -.

Other

ProtoNet

Q9YW06.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Transcription.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 717`	`717`	`Nucleoside triphosphatase II.`	`PRO_0000055189`
`DOMAIN`	`193 384`	`192`	`Helicase ATP-binding.`
`DOMAIN`	`406 566`	`161`	`Helicase C-terminal.`
`NP_BIND`	`206 213`	`8`	`ATP (By similarity).`
`MOTIF`	`331 334`	`4`	`DEXH box.`

Sequence information

Length: 717 AA [This is the length of the unprocessed precursor]

Molecular weight: 84726 Da [This is the MW of the unprocessed precursor]

CRC64: E8FB04661F1EA863 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDMQNITDLY KIDKKTTLYP NIINKYNYMA YLLFPNNATI FNSYITKKEV FEYPMQFAIA 

        70         80         90        100        110        120 
LYPVYKLYWH NINICLNNRF IYLSNEFKNN ISINTVYNLL YNNELKFEDD NIIINGKNLK 

       130        140        150        160        170        180 
ISYSAYSYVT IISQITINIS SLNKYQIYGI IESANYLGIL SSYKQNKYFD KNLFSFTKSE 

       190        200        210        220        230        240 
LRSTMIDVQL KIFEIFISKK NCIISGGTGI GKTTVIPKLF WWFNLLFDGY EFWNTSNENK 

       250        260        270        280        290        300 
NINDFIFKPN FEKNKTILSL PRKALIRQMG INYIKSLGFD NISGSPIILK YKDVKKEKEY 

       310        320        330        340        350        360 
YNNNPILYPF VLSVNRITIN NIKHSNSVII DEIHEHDKFG DIAIAIARTK KKKYNIRNIV 

       370        380        390        400        410        420 
LISATIESDI DNIRIYFKNI VEIYIPGVSL FPVKEIECED KDVISILKNY MPSVGKSVII 

       430        440        450        460        470        480 
FYETIKKINE YKEILESILI DKIYKIYTIH SKITNINAII NKLQNDKKHI HIILSTNYLE 

       490        500        510        520        530        540 
SSITITNATL VIDNGKMYQK KFLTGSTMYI TESMYIQRKG RVGRISKGTY IRTYSKDLLQ 

       550        560        570        580        590        600 
TTFKHINYQY LWEYILVFKY NNMDYYNDLF IKPDDPSRIE NTLNYLKNIN IDIDKYISLL 

       610        620        630        640        650        660 
YSKFNKYEIN MVEYLSIYIN NSTSDIILLN EFIDNIRNSD KYIFPYRLTE IFHKLNVRCR 

       670        680        690        700        710 
CINITETEEG NINCSFVILN NYDGDPFFKL SFEKSNLICR YNKIYYIVSM SPLYLID

Q9YW06 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools