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UniProtKB/Swiss-Prot entry Q9YFI5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_AERPE
Primary accession number Q9YFI5
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on June 26, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: APE_0261.1
From
Aeropyrum pernix [TaxID: 56636] [HAMAP proteome]
Taxonomy Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Desulfurococcaceae; Aeropyrum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K1;
DOI=10.1093/dnares/6.2.83; PubMed=10382966 [NCBI, ExPASy, EBI, Israel, Japan]
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1.";
DNA Res. 6:83-101(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000002; BAA79176.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F72784; F72784.
RefSeq NP_147091.2; -.
3D structure databases
ModBase Q9YFI5.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q9YFI5.
Genome annotation databases
GeneID 1445773; -.
GenomeReviews BA000002_GR; APE_0261.1.
KEGG ape:APE_0261.1; -.
NMPDR fig|272557.1.peg.198; -.
Phylogenomic databases
HOGENOM Q9YFI5; -.
Genome annotation databases
CMR Q9YFI5; APE_0261.1.
Other
ProtoNet Q9YFI5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Dihydroorotase. PRO_0000147266
COMPBIAS   80    83  4     Poly-Ala. 
METAL   61    61        Zinc 1 (By similarity). 
METAL   63    63        Zinc 1 (By similarity). 
METAL   175   175        Zinc 2 (By similarity). 
METAL   224   224        Zinc 2 (By similarity). 
METAL   293   293        Zinc 1 (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46174 Da [This is the MW of the unprocessed precursor] CRC64: AC727B22314AE0F0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAGWTVCVDF LYTGDKMLED ACAVISGERV ERVHTGGFRG QPDLDLRGRS SLALPGVIDM 

        70         80         90        100        110        120 
HVHLRGLKLS YKEDEVSGTA AAASGCVTLV ADMPNTQPPL RTPEALREKL ASLEAGAKVD 

       130        140        150        160        170        180 
YTVYAGVPRS YGEAVEMASM GIAGFKIYPE DLVNLDSIKN VLEAAEEAGI LVVLHPESHD 

       190        200        210        220        230        240 
MFAGPDYGWL RRVARPCHAE AASVELLHDA ARECGCKPRV HITHASCPAT VVESKKRGFT 

       250        260        270        280        290        300 
VDVTPHHLFL SEEEVAGPTH SWGKVNPPLR GVGERSLLTQ LTIEGLVDAI ASDHAPHSTW 

       310        320        330        340        350        360 
EKWMHPAIAP PGFPWLEWWP GFTAARLMRA VGLERFYSMV SQTPSTILGV GDRCLWDGCP 

       370        380        390        400        410        420 
ATISVLQLER TRVYHKGYTK ALYTPVLGME SFDCAATVIR GKIAYTAWEG VRGGATGVLA 


TRVVH
Q9YFI5 in FASTA format

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