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UniProtKB/Swiss-Prot entry Q9YEU2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KPYK_AERPE
Primary accession number Q9YEU2
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 37)
Name and origin of the protein
Protein name Pyruvate kinase
Synonyms PK
EC 2.7.1.40
Gene name
Name: pyk
OrderedLocusNames: APE_0489
From
Aeropyrum pernix [TaxID: 56636] [HAMAP proteome]
Taxonomy Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Desulfurococcaceae; Aeropyrum.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K1;
DOI=10.1093/dnares/6.2.83; PubMed=10382966 [NCBI, ExPASy, EBI, Israel, Japan]
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1.";
DNA Res. 6:83-101(1999).
[2]
 BIOPHYSICOCHEMICAL PROPERTIES, COFACTOR, SUBUNIT, AND REGULATION.
STRAIN=K1;
DOI=10.1074/jbc.M210288200; PubMed=12654928 [NCBI, ExPASy, EBI, Israel, Japan]
Johnsen U., Hansen T., Schoenheit P.;
"Comparative analysis of pyruvate kinases from the hyperthermophilic archaea Archaeoglobus fulgidus, Aeropyrum pernix, and Pyrobaculum aerophilum and the hyperthermophilic bacterium Thermotoga maritima: unusual regulatory properties in hyperthermophilic archaea.";
J. Biol. Chem. 278:25417-25427(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000002; BAA79454.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B72745; B72745.
RefSeq NP_147274.1; -.
3D structure databases
HSSP P11974; 1PKN. [HSSP ENTRY / PDB]
ModBase Q9YEU2.
Family and domain databases
InterPro IPR001697; Pyr_Knase.
IPR015813; Pyrv/PenolPyrv_Kinase_cat.
IPR015793; Pyrv_Knase_brl.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.60; Pyrv/PenolPyrv_Kinase_cat; 1.
PANTHER PTHR11817; Pyruvate_kinase; 1.
Pfam PF00224; PK; 1.
Pfam graphical view of domain structure.
PRINTS PR01050; PYRUVTKNASE.
ProDom PD001009; Pyruvate_kinase; 2.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01064; pyruv_kin; 1.
PROSITE PS00110; PYRUVATE_KINASE; FALSE_NEG.
BLOCKS Q9YEU2.
ProtoNet Q9YEU2.
Genome annotation databases
GeneID 1444673; -.
GenomeReviews BA000002_GR; APE_0489.
KEGG ape:APE_0489; -.
NMPDR fig|272557.1.peg.382; -.
Phylogenomic databases
HOGENOM Q9YEU2; -.
Genome annotation databases
CMR Q9YEU2; APE_0489.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycolysis; Kinase; Magnesium; Metal-binding; Pyruvate; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   458  458     Pyruvate kinase. PRO_0000295180
ACT_SITE   212   212        By similarity. 
METAL   214   214        Magnesium (By similarity). 
METAL   235   235        Magnesium (By similarity). 
METAL   236   236        Magnesium (By similarity). 
Sequence information
Length: 458 AA [This is the length of the unprocessed precursor] Molecular weight: 50487 Da [This is the MW of the unprocessed precursor] CRC64: 3D8E11A37A0088E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRGPVKIVAT VGPSSSSASI LAQMLSLGVD VARINASHGG VEQWNSMLES LRRAEEAVGK 

        70         80         90        100        110        120 
RVGVAVDLEG PRVRTGNSEP VKLEKGDLVT LGFMEGDVPV DARQFFETID EGDIVLLDDG 

       130        140        150        160        170        180 
KIILQVESVE GFRVKARVLE GGVLGPRKGV VVRGKEPDLP PLSAKDRRAL EFFADKGVSH 

       190        200        210        220        230        240 
VYVSFARSAE HVEKVRTVVR RLGLRQARIF AKIEGPSGVS RIGEIAEASD GVIIARGDLG 

       250        260        270        280        290        300 
MHYSLEELPE IQELIVWEAR KRYKTVVLAT EFLSSMIEKP VPTRSEVVDI YQAVLQTADA 

       310        320        330        340        350        360 
LMLTGETAIG KYPVKSVQWM AKISSRAYKK LATSPPERPR PTSTPYKLAL GLVELAESLD 

       370        380        390        400        410        420 
SPLVVYSKTG RFAERLASFK PLKTFYVGVP SREVERVVRH LWGAEPIVVG DYPYEAGLAK 

       430        440        450 
TYEKLRRENI IHGDETVVEA AWSSERGIYI IRVRNLEF
Q9YEU2 in FASTA format

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