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UniProtKB/Swiss-Prot entry Q9YA72

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KHSE_AERPE
Primary accession number Q9YA72
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 2001
Sequence was last modified on July 10, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Homoserine kinase
Synonyms HSK
HK
EC 2.7.1.39
Gene name
Name: thrB
OrderedLocusNames: APE_2067.1
From
Aeropyrum pernix [TaxID: 56636] [HAMAP proteome]
Taxonomy Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Desulfurococcaceae; Aeropyrum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K1;
DOI=10.1093/dnares/6.2.83; PubMed=10382966 [NCBI, ExPASy, EBI, Israel, Japan]
Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
"Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1.";
DNA Res. 6:83-101(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000002; BAA81077.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E72511; E72511.
RefSeq NP_148358.2; -.
3D structure databases
HSSP Q58504; 1H72. [HSSP ENTRY / PDB]
ModBase Q9YA72.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004413; Molecular function: homoserine kinase activity (inferred from electronic annotation from HAMAP).
GO:0016310; Biological process: phosphorylation (inferred from electronic annotation from InterPro).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00384; -; 1.
PBIL [Tree]
InterPro IPR006204; GHMP_kinase.
IPR013750; GHMP_kinase_C.
IPR006203; GHMP_knse_ATP_bd_CS.
IPR000870; Homoser_kin.
IPR014721; Ribosomal_S5_D2-type_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
Pfam PF08544; GHMP_kinases_C; 1.
PF00288; GHMP_kinases_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000676; Homoser_kin; 1.
PRINTS PR00958; HOMSERKINASE.
TIGRFAMs TIGR00191; thrB; 1.
PROSITE PS00627; GHMP_KINASES_ATP; 1.
ProtoNet Q9YA72.
Genome annotation databases
GeneID 1445166; -.
GenomeReviews BA000002_GR; APE_2067.1.
KEGG ape:APE_2067.1; -.
NMPDR fig|272557.1.peg.1466; -.
Phylogenomic databases
HOGENOM Q9YA72; -.
Genome annotation databases
CMR Q9YA72; APE_2067.1.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   313  313     Homoserine kinase. PRO_0000156638
NP_BIND   92   102  11     ATP (Potential). 
Sequence information
Length: 313 AA [This is the length of the unprocessed precursor] Molecular weight: 31994 Da [This is the MW of the unprocessed precursor] CRC64: 6D6424FA879FFA96 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MACSRARARA YSSAANLGPG FDALAVALDA YYDEVEVRVC SGGNSVYVDE VEGKFSSGVL 

        70         80         90        100        110        120 
QGPNTAAEAV RGLLNMEGVE AEVGIRVYKG VPPGRGLGSS GASAAAAVAA VSHALALEVP 

       130        140        150        160        170        180 
VDRLVFYAGL GERAAAGQPH FDNAAASILG GLAVVASDAA GKLRVFRVPF KAWFAVVTPM 

       190        200        210        220        230        240 
NPVPQGKTGV MRKVLPENVS FRDAVRNFSR AAGIVAAAVN GDLKSMGALM MSDEIVEPRR 

       250        260        270        280        290        300 
RSYVPCYTQV RKAALQAGAL GFSLSGAGPS MIALAPSSEA AREIAAAMEE SCICCDNPMT 

       310 
VAAEPAPGAS VVG
Q9YA72 in FASTA format

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