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UniProtKB/Swiss-Prot entry Q9Y7T4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATG1_SCHPO
Primary accession number Q9Y7T4
Secondary accession numbers None
Integrated into Swiss-Prot on April 26, 2005
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name Serine/threonine-protein kinase atg1
Synonyms EC 2.7.11.1
Autophagy-related protein 1
Serine/threonine-protein kinase ppk36
Gene name
Name: atg1
Synonyms: ppk36
ORFNames: SPCC63.08c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
IDENTIFICATION.
DOI=10.1128/EC.4.4.799-813.2005; PubMed=15821139 [NCBI, ExPASy, EBI, Israel, Japan]
Bimbo A., Jia Y., Poh S.L., Karuturi R.K.M., den Elzen N., Peng X., Zheng L., O'Connell M., Liu E.T., Balasubramanian M.K., Liu J.;
"Systematic deletion analysis of fission yeast protein kinases.";
Eukaryot. Cell 4:799-813(2005).
[3]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nbt1222; PubMed=16823372 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346, AND MASS SPECTROMETRY.
DOI=10.1021/pr7006335; PubMed=18257517 [NCBI, ExPASy, EBI, Israel, Japan]
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329672; CAB40012.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T41509; T41509.
RefSeq NP_587982.1; -.
3D structure databases
HSSP O14965; 1MQ4. [HSSP ENTRY / PDB]
ModBase Q9Y7T4.
Organism-specific databases
GeneDB_Spombe SPCC63.08c; -.
Gene expression databases
ArrayExpress Q9Y7T4; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0005634; Cellular component: nucleus (inferred from direct assay from GeneDB_SPombe).
GO:0004674; Molecular function: protein serine/threonine kinase activity (traceable author statement from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9Y7T4.
Genome annotation databases
GeneID 2539461; -.
KEGG spo:SPCC63.08c; -.
NMPDR fig|4896.1.peg.320; -.
Other
ProtoNet Q9Y7T4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   830  830     Serine/threonine-protein kinase atg1. PRO_0000085652
DOMAIN   14   307  294     Protein kinase. 
NP_BIND   20    28  9     ATP (By similarity). 
ACT_SITE   157   157        Proton acceptor (By similarity). 
BINDING   43    43        ATP (By similarity). 
MOD_RES   346   346        Phosphoserine. 
Sequence information
Length: 830 AA [This is the length of the unprocessed precursor] Molecular weight: 91585 Da [This is the MW of the unprocessed precursor] CRC64: 8DB76C502BD83425 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNLQTSTNQT IGPYVIRSEI GRGSFAIVYK GKHTETNRVI SIKSVLTKKL TKKLLENLES 

        70         80         90        100        110        120 
EISILKEIRH VHVVELIDCI KAGRFIHLVM EYCSLGDLSY FIRKREKFNS IPSLAWINID 

       130        140        150        160        170        180 
HPPVYKAGLN ETLVRHFTQQ LASALQFLRS RSLIHRDVKP QNLLLQPPPT AAYLEEHPQF 

       190        200        210        220        230        240 
VGSPKLPMLK LADFGFARYL QTSSMAETLC GSPLYMAPEI LRYEKYDAKA DLWSVGAVLY 

       250        260        270        280        290        300 
EMAVGKPPFK APNHVELLRR IQKAKDVIKF PEEAFIHPDI KTLICALLKQ NPADRIDYDG 

       310        320        330        340        350        360 
FFSSIVVTTP LDDASTLTGS DIQDAVKEIN IPSSSPAYIT DFFPKSNPGA PAPPGGLLRQ 

       370        380        390        400        410        420 
AFQAQGSSIQ PSEITGRRVP HRYAQDGNTL PYTPVFPPES APAASIFPPR LTSKQPIPMA 

       430        440        450        460        470        480 
SPAKLTSDTS NKSSAYVVVD HHPIISSTQL SNESLTHEQS INGNSPSPNE GVFQGSFSPE 

       490        500        510        520        530        540 
SAPVNNHAFP HTSRMQIPYM KPNAFPSNPT YIASTPVTQL RRAFEQATAH VPQSGGGARN 

       550        560        570        580        590        600 
KSALERALNV ANARLNEVVV DGMTDNGNTS LPTKESNLDN NVNIIQPSLP DTGKRLLDVL 

       610        620        630        640        650        660 
ESIAMKSNSV YHLAEVKLAQ IIPSLSDEMK PGDTLLDRPL TPFSLVMLAK ESYVLYERDI 

       670        680        690        700        710        720 
ELLQVAFDGV AAFWANSEER ASPDCQQAIE WFRQRYSESL EKSQFLREII ISQSAAHSLP 

       730        740        750        760        770        780 
TTKPVSASQL IYHRALDLSR NAATSELSGN DAQACLQNYR LAAHLLESLL ESNFSTPDGA 

       790        800        810        820        830 
NDSNNSVTIR NLIALITKRQ ELLQSKQIQA NVANKVTESV AKITLAPNLA 

Q9Y7T4 in FASTA format

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