[1]	NUCLEOTIDE SEQUENCE [MRNA] (CDY1) (ISOFORM 2). DOI=10.1126/science.278.5338.675; PubMed=9381176 [NCBI, ExPASy, EBI, Israel, Japan] Lahn B.T., Page D.C.; "Functional coherence of the human Y chromosome."; Science 278:675-680(1997).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (CDY1A) (ISOFORM 1). TISSUE=Testis; DOI=10.1038/7771; PubMed=10192397 [NCBI, ExPASy, EBI, Israel, Japan] Lahn B.T., Page D.C.; "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."; Nat. Genet. 21:429-433(1999).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (CDY1B) (ISOFORM 2). DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	FUNCTION. DOI=10.1073/pnas.082248899; PubMed=12072557 [NCBI, ExPASy, EBI, Israel, Japan] Lahn B.T., Tang Z.L., Zhou J., Barndt R.J., Parvinen M., Allis C.D., Page D.C.; "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis."; Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002).
[5]	X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 281-531. Structural genomics consortium (SGC); "Crystal structure of acetyltransferases domain of human testis-specific chromodomain protein Y 1."; Submitted (OCT-2006) to the PDB data bank.

Comments

FUNCTION: Has histone acetyltransferase activity, with a preference for histone H4.
CATALYTIC ACTIVITY: Acetyl-CoA + histone = CoA + acetylhistone.
SUBCELLULAR LOCATION: Nucleus (By similarity).
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name 1

Isoform ID Q9Y6F8-1

This is the isoform sequence displayed in this entry.

Name 2

Isoform ID Q9Y6F8-2

Features which should be applied to build the isoform sequence: VSP_001079.
TISSUE SPECIFICITY: Testis specific.
SIMILARITY: Contains 1 chromo domain.
WEB RESOURCE: Name=GeneReviews; URL="http://www.genetests.org/query?gene=CDY1";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF000981; AAC52116.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF080597; AAD22732.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC132929; AAI32930.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC132955; AAI32956.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001003894.1; -.
NP_004671.1; -.
NP_733841.1; -.

UniGene

Hs.159281

3D structure databases

PDB

2FBM; X-ray; 2.28 A; A/B/C=281-531.

[ExPASy / RCSB / EBI]

PDBsum

2FBM; -.

SMR

Q9Y6F8; 1-64, 282-540.

ModBase

Q9Y6F8.

Organism-specific databases

H-InvDB

HIX0056659; -.
HIX0077344; -.

HGNC

HGNC:1809; CDY1.
HGNC:23920; CDY1B.

GenAtlas

CDY1.

MIM

400016; gene. [NCBI / EBI]

PharmGKB

PA26354; -.

GeneCards

Q9Y6F8.

Gene expression databases

CleanEx

HS_CDY1; -.
HS_CDY1B; -.

GermOnline

ENSG00000172288; Homo sapiens.
ENSG00000172352; Homo sapiens.

Ontologies

GO:0000785;	Cellular component: chromatin (inferred from electronic annotation from InterPro).
GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0003682;	Molecular function: chromatin binding (inferred from electronic annotation from InterPro).
GO:0004402;	Molecular function: histone acetyltransferase activity (inferred from electronic annotation from EC).
GO:0006333;	Biological process: chromatin assembly or disassembly (inferred from electronic annotation from InterPro).
GO:0007283;	Biological process: spermatogenesis (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR000953; Chromodomain.
Graphical view of domain structure.

Pfam

PF00385; Chromo; 1.
Pfam graphical view of domain structure.

PRINTS

PR00504; CHROMODOMAIN.

SMART

SM00298; CHROMO; 1.
SMART graphical view of domain structure.

PROSITE

PS00598; CHROMO_1; 1.
PS50013; CHROMO_2; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q9Y6F8.

Genome annotation databases

Ensembl

ENSG00000172288; Homo sapiens. [Contig view]
ENSG00000172352; Homo sapiens. [Contig view]

GeneID

253175; -.
9085; -.

KEGG

hsa:253175; -.
hsa:9085; -.

Phylogenomic databases

HOVERGEN

Q9Y6F8; -.

Other

Q9Y6F8; -.

92071; -.

CDY1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Acyltransferase; Alternative splicing; Nucleus; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 540`	`540`	`Testis-specific chromodomain protein Y 1.`	`PRO_0000080219`
`DOMAIN`	`6 66`	`61`	`Chromo.`
`VAR_SEQ`	`532 540`		`YVENKIDEF -> IPLLGYKAAFPPRKTQNDQRWCP (in isoform 2).`	`VSP_001079`
`STRAND`	`284 290`	`7`
`STRAND`	`292 299`	`8`
`STRAND`	`302 305`	`4`
`HELIX`	`311 326`	`16`
`STRAND`	`330 336`	`7`
`HELIX`	`347 356`	`10`
`HELIX`	`358 378`	`21`
`STRAND`	`383 387`	`5`
`HELIX`	`394 397`	`4`
`HELIX`	`399 401`	`3`
`STRAND`	`402 408`	`7`
`STRAND`	`412 414`	`3`
`HELIX`	`417 420`	`4`
`HELIX`	`428 436`	`9`
`HELIX`	`438 445`	`8`
`STRAND`	`450 452`	`3`
`HELIX`	`453 458`	`6`
`STRAND`	`463 466`	`4`
`HELIX`	`472 482`	`11`
`HELIX`	`487 498`	`12`
`TURN`	`499 501`	`3`
`HELIX`	`502 520`	`19`
`HELIX`	`523 530`	`8`

Sequence information

Length: 540 AA [This is the length of the unprocessed precursor]

Molecular weight: 60473 Da [This is the MW of the unprocessed precursor]

CRC64: 5B7AEB789092A265 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE 

        70         80         90        100        110        120 
KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNRK LFAASKNVRR 

       130        140        150        160        170        180 
KAASILSDTK NMEIINSTIE TLAPDSPFDH KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG 

       190        200        210        220        230        240 
KLLRDPLSRP GAEQTGIQNK TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT 

       250        260        270        280        290        300 
TDMHTSVPRV KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS 

       310        320        330        340        350        360 
TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF VKHLRNNRNT 

       370        380        390        400        410        420 
ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP LCDLVWANEK AWFQTPYTTF 

       430        440        450        460        470        480 
GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK LTAREACAKG LVSQVFLTGT FTQEVMIQIK 

       490        500        510        520        530        540 
ELASYNPIVL EECKALVRCN IKLELEQANE RECEVLRKIW SSAQGIESML KYVENKIDEF

Q9Y6F8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools