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UniProtKB/Swiss-Prot entry Q9Y680


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FKBP7_HUMAN
Primary accession number Q9Y680
Secondary accession numbers Q86U65 Q96DA4 Q9Y6B0
Integrated into Swiss-Prot on September 19, 2002
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 72)
Name and origin of the protein
Protein name FK506-binding protein 7 [Precursor]
Synonyms EC 5.2.1.8
Peptidyl-prolyl cis-trans isomerase
PPIase
Rotamase
FKBP-23
Gene name
Name: FKBP7
Synonyms: FKBP23
ORFNames: UNQ670/PRO1304
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Pituitary tumor;
Guan Z., Zhang Q., Dai M., Song H., Mao Y., Wu X., Mao M., Fu G., Luo M., Chen J., Hu R.;
"Human FK506-binding protein (FKBP23)-isoform gene.";
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Pituitary;
Han Z., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.;
"Human FK506-binding protein mRNA, complete cds.";
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF100751; AAD43015.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF092137; AAD40379.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359015; AAQ89374.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT007122; AAP35786.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC009711; AAH09711.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_851939.1; -.
UniGene Hs.410378
3D structure databases
HSSP Q02790; 1N1A. [HSSP ENTRY / PDB]
ModBase Q9Y680.
Organism-specific databases
H-InvDB HIX0002629; -.
HGNC HGNC:3723; FKBP7.
GenAtlas FKBP7.
HPA HPA008707; -.
MIM 607062; gene. [NCBI / EBI]
PharmGKB PA28164; -.
GeneCards Q9Y680.
Gene expression databases
ArrayExpress Q9Y680; -.
CleanEx HS_FKBP7; -.
GermOnline ENSG00000079150; Homo sapiens.
Ontologies
GO
GO:0005788; Cellular component: endoplasmic reticulum lumen (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002048; EF_hand_Ca_bd.
IPR000886; ER_targeting_sequence.
IPR001179; PPIase_FKBP.
Graphical view of domain structure.
PANTHER PTHR10516; PPIase_FKBP; 1.
Pfam PF00036; efhand; 2.
PF00254; FKBP_C; 1.
Pfam graphical view of domain structure.
SMART SM00054; EFh; 2.
SMART graphical view of domain structure.
PROSITE PS00018; EF_HAND_1; 2.
PS50222; EF_HAND_2; 2.
PS00014; ER_TARGET; 1.
PS50059; FKBP_PPIASE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9Y680.
Genome annotation databases
Ensembl ENSG00000079150; Homo sapiens. [Contig view]
GeneID 51661; -.
KEGG hsa:51661; -.
Phylogenomic databases
HOGENOM Q9Y680; -.
HOVERGEN Q9Y680; -.
Other
LinkHub Q9Y680; -.
SOURCE FKBP7; Homo sapiens.
ProtoNet Q9Y680.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Calcium; Endoplasmic reticulum; Glycoprotein; Isomerase; Repeat; Rotamase; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    23  23     Potential. 
CHAIN   24   259  236     FK506-binding protein 7. PRO_0000025513
DOMAIN   53   182  130     PPIase FKBP-type. 
DOMAIN   182   217  36     EF-hand 1. 
DOMAIN   226   259  34     EF-hand 2. 
CA_BIND   195   206  12     1 (Potential). 
CA_BIND   239   250  12     2 (Potential). 
MOTIF   256   259  4     Prevents secretion from ER (Potential). 
CARBOHYD   45    45        N-linked (GlcNAc...) (Potential). 
CARBOHYD   158   158        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   125   161        Missing (in isoform 2). VSP_005187
CONFLICT   124   124        Y -> H (in Ref. 2). 
Sequence information
Length: 259 AA [This is the length of the unprocessed precursor] Molecular weight: 30009 Da [This is the MW of the unprocessed precursor] CRC64: 886A1F3F5ACB9E78 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY 

        70         80         90        100        110        120 
DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 

       130        140        150        160        170        180 
KEGYGSLEEV FLLQNILVSC HRTTLHVLKC MYLLVLNNNT CAEGKIPPDA TLIFEIELYA 

       190        200        210        220        230        240 
VTKGPRSIET FKQIDMDNDR QLSKAEINLY LQREFEKDEK PRDKSYQDAV LEDIFKKNDH 

       250 
DGDGFISPKE YNVYQHDEL 

Q9Y680 in FASTA format

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