[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.96.6.2828; PubMed=10077596 [NCBI, ExPASy, EBI, Israel, Japan]
Cai S.-Y.,
Babbitt R.W.,
Marchesi V.T.;
"A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.";
Proc. Natl. Acad. Sci. U.S.A. 96:2828-2833(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/35012518; PubMed=10830953 [NCBI, ExPASy, EBI, Israel, Japan]
Hattori M.,
Fujiyama A.,
Taylor T.D.,
Watanabe H.,
Yada T.,
Park H.-S.,
Toyoda A.,
Ishii K.,
Totoki Y.,
Choi D.-K.,
Groner Y.,
Soeda E.,
Ohki M.,
Takagi T.,
Sakaki Y.,
Taudien S.,
Blechschmidt K.,
Polley A.,
Menzel U., ![]()
Delabar J.,
Kumpf K.,
Lehmann R.,
Patterson D.,
Reichwald K.,
Rump A.,
Schillhabel M.,
Schudy A.,
Zimmermann W.,
Rosenthal A.,
Kudoh J.,
Shibuya K.,
Kawasaki K.,
Asakawa S.,
Shintani A.,
Sasaki T.,
Nagamine K.,
Mitsuyama S.,
Antonarakis S.E.,
Minoshima S.,
Shimizu N.,
Nordsiek G.,
Hornischer K.,
Brandt P.,
Scharfe M.,
Schoen O.,
Desario A.,
Reichelt J.,
Kauer G.,
Bloecker H.,
Ramser J.,
Beck A.,
Klages S.,
Hennig S.,
Riesselmann L.,
Dagand E.,
Wehrmeyer S.,
Borzym K.,
Gardiner K.,
Nizetic D.,
Francis F.,
Lehrach H.,
Reinhardt R.,
Yaspo M.-L.;
"The DNA sequence of human chromosome 21.";
Nature 405:311-319(2000).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-141.
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Jedrychowski M.,
Schwartz D.,
Elias J.E.,
Villen J.,
Li J.,
Cohn M.A.,
Cantley L.C.,
Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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[5]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415 AND SER-552, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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- FUNCTION: May deubiquitinate one or more critical proteins that are involved in the condensation of mitotic chromosomes, possibly acting selectively on histones H2A and H2B, the major ubiquitinated proteins of chromatin. It is able to deubiquitinate histone H2A in vitro, the phosphorylated form of the protein is also enzymatically active.
- CATALYTIC ACTIVITY: Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
- TISSUE SPECIFICITY: Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- PTM: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition.
- SIMILARITY: Belongs to the peptidase C19 family [view classification].
- SIMILARITY: Contains 1 UBP-type zinc finger.
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